Results 61 to 70 of about 15,617 (227)

Alkalinised lidocaine as an anaesthetic before onabotulinumtoxinA injections. a randomised trial

BJU International, Volume 135, Issue 4, Page 638-647, April 2025.
Objectives To evaluate the effect of intravesical alkalinised lidocaine as an anaesthetic treatment on procedural pain during intradetrusor onabotulinumtoxinA (BTX‐A) injections for overactive bladder. Patients and Methods This single‐centre, randomised, double‐blind, placebo‐controlled two period crossover trial was conducted on women scheduled for ...
Meryam El Issaoui, Marlene Elmelund, Niels Klarskov   +2 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Effectiveness of Extracorporeal Shock Wave Therapy after Botulinum Toxin Injection for Post-Stroke Upper Extremity Spasticity: A Randomized Controlled Study

Toxins
Post-stroke spasticity is a common complication that limits the functional performance of patients. Botulinum toxin (BTx) is an effective treatment for spasticity. Numerous researchers have applied extracorporeal shock wave therapy (ESWT) to address post-
Junhee Lee, Seung Nam Yang
doaj   +1 more source

Comparison of Dose Increments of Botulinum Toxin A with Surgery as Primary Treatment for Infantile Esotropia and Partially Accommodative Esotropia

Clinical Ophthalmology, 2022
Fatemah T AlShamlan, Fatimah Alghazal Pediatric Ophthalmology and Strabismus Department, Dhahran Eye Specialist Hospital, Dhahran, Saudi ArabiaCorrespondence: Fatemah T AlShamlan, Email dr_fate82@hotmail.comPurpose: To compare the effect of increment ...
AlShamlan FT, Alghazal F
doaj  

Inhibition of Ornithine Decarboxylase 1 Mitigates Denervation‐Induced Muscle Atrophy by Suppressing Proteolysis and Preserving Muscle Stem Cell Homeostasis

Cell Proliferation, EarlyView.
Polyamine metabolism is innervation responsive and involved in denervation‐induced muscle atrophy. Inhibition of polyamine metabolism attenuates muscle atrophy by restraining proteolysis and preserving MuSCs homeostasis. Denervation‐induced activation of FAP‐derived FGF7 drives premature MuSCs activation, while DFMO suppresses this paracrine cue to ...
Mingming Zhang, Feifan Chang, Siliang Ge, Fuming Cao, Pincong Fu, Haobo Zhang, Ming Chen, Yi Li, Peifu Tang, Pengbin Yin   +9 more
wiley   +1 more source

Safety of combined salivary gland and multilevel intramuscular onabotulinumtoxinA injections with and without ethanol in pediatric patients with cerebral palsy: A retrospective study

Journal of Pediatric Rehabilitation Medicine, 2019
OBJECTIVE: To evaluate the safety of combining salivary gland onabotulinumtoxinA (BTX-A) injections for sialorrhea with intramuscular BTX-A injections for spasticity in the same procedure.
Hannah Shoval, Jared Levin, Kathleen Friel, Heakyung Kim   +3 more
doaj   +1 more source

Postherpetic Neuralgia: Mechanisms, Risk Factors, and Stratified Management—A Narrative Review

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
The incidence of PHN is increasing, posing a substantial public health burden. Its pathogenesis involves VZV reactivation, peripheral and central sensitization, and genetic susceptibility, with key risk factors including older age, severe acute pain, extensive rash, immunocompromise, comorbidities, and delayed treatment.
Fei Tang, Fukun Zhao
wiley   +1 more source

BTX Degradation: The concept of microbial integration

, 2017
The concept of microbial integration was carried out to examine bacterial and fungal activity on bezene, toluence and xylene (BTX) degradation in a batch reactor.
Chukwuemeka Peter Ukpaka
core   +1 more source

High‐Yield Production and Cost‐Effective Purification of an Alkali‐Resistant Hexameric Protein A Variant for Antibody Affinity Chromatography

Biotechnology Journal, Volume 21, Issue 6, June 2026.
Graphical Abstract and Lay Summary We present a scalable method for producing the antibody‐binding ligand Z6AlkC, a six‐repeat, alkali‐resistant Protein A–derived Z domain with a terminal cysteine. The ligand was produced at high yield via extracellular secretion in bioreactors and subsequently purified by high‐productivity ultradiafiltration with low ...
Carolina Mota Natal, Claudia Lacombe, Alexander Zollner, Catarina Domingos, José Mendes, André Nascimento, Ana Margarida Gonçalves Carvalho Dias, Arménio Jorge Moura Barbosa, Cristina Peixoto, Birgit Wiltschi, Alois Jungbauer, Ana Cecília Afonso Roque   +11 more
wiley   +1 more source

Effect of the masseter muscle injection of botulinum toxin A on the mandibular bone growth of developmental rats

Maxillofacial Plastic and Reconstructive Surgery, 2018
Background The objective of this study was to evaluate the influence of masticatory muscle injection of botulinum toxin type A (BTX-A) on the growth of the mandibular bone in vivo. Methods Eleven Sprague-Dawley rats were used, and BTX-A (n = 6) or saline
Hyun Seok, Seong-Gon Kim, Min-Keun Kim, Insan Jang, Janghoon Ahn   +4 more
doaj   +1 more source