Results 91 to 100 of about 552,293 (286)

Towards Cancer Hybrid Automata

open access: yes, 2012
This paper introduces Cancer Hybrid Automata (CHAs), a formalism to model the progression of cancers through discrete phenotypes. The classification of cancer progression using discrete states like stages and hallmarks has become common in the biology ...
Andreas Witzel   +4 more
core   +2 more sources

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

open access: yesAdvanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore   +20 more
wiley   +1 more source

The Effect of Photoperiod to Break Dormancy of Porang’s (Amorphophallus muelleri Blume) Tuber and Growth

open access: yesResearch Journal of Life Science, 2017
The aim of the research was to obtain the method of porang’s tuber dormancy breaking. The source of porang’s tuber were obtained from Rejosari Village, Bantur Subdistrict, Malang Regency.
Serafinah Indriyani, Wahyu Widoretno
doaj   +1 more source

Asymmetric patterns of gap junctional communication in developing chicken skin [PDF]

open access: yes, 1993
To study the pattern of gap junctional communication in chicken skin and feather development, we injected Lucifer Yellow into single cells and monitored the transfer of the fluorescent dye through gap junctions.
Chuong, Cheng-Ming   +2 more
core  

TEAD1 Enhances Exosome Secretion and Promotes Exosome‐Mediated Tissue Regeneration

open access: yesAdvanced Science, EarlyView.
TEAD1 functions as a crucial molecular switch regulating exosome secretion in various cell types. TEAD1 enhances exosome secretion by upregulating key proteins associated with exosome secretion, including RAB11, CD9, and SNAP23. This study reveals a novel role for TEAD1 in regulating exosome secretion and tissue regeneration, particularly in diabetic ...
Yan Pu   +9 more
wiley   +1 more source

Impact induced mechanical damage of Agria potato tubers cultivated in different regimes

open access: yesResearch in Agricultural Engineering, 2006
The Agria potato tubers were grown in 2005 in cultivation regimes involving different irrigation and fertilisation levels and forms. The impact induced tuber damage was simulated dynamically by an impact pendulum test and studied with the aim to detect ...
J. Blahovec, A. Hejlová, J. Vacek
doaj   +1 more source

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

open access: yesAdvanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia   +5 more
wiley   +1 more source

Impact induced mechanical damage of Agria potato tubers

open access: yesResearch in Agricultural Engineering, 2005
Potato variety Agria was cultivated in different fertilisation and/or irrigation regimes. Tuber damage after impact was studied two months after the harvest with aim to find some relation between the regime of cultivation and impact test tuber damage. It
J. Blahovec
doaj   +1 more source

Size‐Modulated Mesoderm‐Endoderm Divergence and Myocardial Cavitation in Micropatterned Cardioids

open access: yesAdvanced Science, EarlyView.
Micropatterned cardioids, CRISPR‐engineered reporter hiPSCs, deep‐tissue imaging, and single‐cell RNA sequencing are integrated to model mesoderm‐endoderm co‐development. Heart‐foregut crosstalk promotes single large cavitation inside cardioids, resembling early heart chamber formation. ABSTRACT The human heart, originating from the splanchnic mesoderm,
Plansky Hoang   +12 more
wiley   +1 more source

BLADE‐ON‐PETIOLE Genes Enable Genetic Bottleneck Mitigation Through Cross‐Species Repurposing of Floral Persistence Traits

open access: yesAdvanced Science, EarlyView.
This study shows that BLADE‐ON‐PETIOLE (BOP) proteins regulate floral abscission and senescence in tomato by interacting with TFAM1 to form transcriptional condensates controlling the ARABIDOPSIS THALIANA HOMEOBOX GENE 1 (ATH1)‐mediated abscission pathway.
Nan Xiao   +7 more
wiley   +1 more source

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