Results 61 to 70 of about 20,955 (176)

Efficacy and Safety of Dupilumab in Chinese Adult Patients With Chronic Rhinosinusitis With Nasal Polyps: A Randomized, Placebo‐Controlled, Phase III Trial

Allergy, EarlyView.
Dupilumab significantly improved nasal polyp score, nasal congestion, olfaction, total symptom score, and disease‐specific quality of life in Chinese patients with uncontrolled CRSwNP. Incidence of treatment‐emergent adverse events was similar between dupilumab and placebo.
Mu Xian, Menglin Wang, Changqing Zhao, Lijia Wan, Yu Xu, Juan Meng, Rui Xu, Xicheng Song, Li Shi, Yucheng Yang, Yan Jiang, Yanzhen Wu, Bethany Ling, Vivian Li, Andrew P. Fontenot, Lacey R. Robinson, Neelam A. Phadke, Chengshuo Wang, Luo Zhang   +18 more
wiley   +1 more source

Effects of Budesonide and Fluticasone Propionate in Pediatric Asthma Patients

Pediatrics and Neonatology, 2010
Cytokines and chemokines play important roles in asthma. However, little information exists on the effects of inhaled corticosteroids on cytokine and chemokine plasma levels in childhood asthma.
Lin-Yu Kuo, Chih-Hsing Hung, Hsing-I Tseng, Jiunn-Ren Wu, Yuh-Jyh Jong, Yu-Te Chu   +5 more
doaj   +1 more source

Efficacy of Full and Limited Endoscopic Sinus Surgery in Chronic Rhinosinusitis With Nasal Polyps: A Randomised Controlled Trial

Allergy, EarlyView.
Both Full and Limited FESS result in clinically meaningful relief of disease‐specific HRQoL and nasal breathing, effectively improving nasal symptoms and sleep disturbance in CRSwNP patients. Clinically meaningful difference in decrease of SNOT‐22 scores between the groups was not found at 12‐ and 24–month follow‐up.
P. Virkkula, S. Hammarén‐Malmi, A. Laulajainen‐Hongisto, M. Lilja, J. Wikstén, L. Hafrén, P. Kauppi, S. Reitsma, K. Pajala, J. Sahlman, S. Toppila‐Salmi   +10 more
wiley   +1 more source

Effect of nebulized budesonide on respiratory mechanics and oxygenation in acute lung injury/acute respiratory distress syndrome: Randomized controlled study

Saudi Journal of Anaesthesia, 2017
Background: We tested the hypothesis that nebulized budesonide would improve lung mechanics and oxygenation in patients with early acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS) during protective mechanical ventilation strategy
Hatem Saber Mohamed, Mona Mohamed Abdel Meguid   +1 more
doaj   +1 more source

European Guidelines on Eosinophilic Esophagitis: Evidence‐Based Statements and Recommendations for Diagnosis and Management in Children and Adults. Part 1: Diagnosis, Epidemiology and Natural History

Allergy, EarlyView.
The European evidence‐based guidelines on eosinophilic esophagitis (Part 1). This infographic summarizes the methodological framework and core clinical outputs of the updated consensus developed by multidisciplinary experts from EUREOS, EAACI, ESPGHAN, and ESP.
Alfredo J. Lucendo, Javier Molina‐Infante, Ángel Arias, Ulrike von Arnim, Henrik Bergquist, Luc Biedermann, Albert J. Bredenoord, Marie Carlson, Javier Chahuan, Jorge Amil Dias, Thomas Eiwegger, Sara Feo‐Ortega, Sandra L. Garcia‐Dionisio, Matteo Ghisa, Jesús González‐Cervera, Thomas Greuter, Danila Guagnozzi, Carolina Gutiérrez‐Junquera, Lucía Gutiérrez‐Ramírez, Cord Langner, Helen Larsson, Anne Lund Krarup, Salvatore Oliva, Alexandra Papadopoulou, Francesca Racca, Cecilio Santander, Edoardo Vincenzo Savarino, Christoph Schlag, Alain M. Schoepfer, Martin A. Storr, Antonio Tejera‐Muñoz, Noam Zevit, Stephen E. Attwood, Alex Straumann   +33 more
wiley   +1 more source

Clinical Trial: Dupilumab Improves Eosinophilic Oesophagitis Outcomes Versus Placebo Regardless of Comorbidities or Treatment History in a Randomised Clinical Trial

Alimentary Pharmacology &Therapeutics, EarlyView.
Dupilumab improved all histological, symptomatic, and endoscopic outcomes assessed at Week 24 versus placebo in patients with eosinophilic oesophagitis, regardless of demographics, disease characteristics, treatment history, or type 2 inflammatory disease comorbidities.
Evan S. Dellon, Marc E. Rothenberg, Jonathan M. Spergel, Albert J. Bredenoord, Antonella Cianferoni, Changming Xia, Margee Louisias, Allen Radin   +7 more
wiley   +1 more source

COMPARATIVE COST-MINIMIZATION AND BUDGET-IMPACT ANALYSIS OF FIXED-DOSE INHALED CORTICOSTEROID / LONG-ACTING BETAAGONIST COMBINATIONS IN THE TREATMENT OF ASTHMA

Фармакоэкономика, 2017
Comparative pharmacoeconomic analysis of fixed-dose combinations (FDC) vilanterol / fluticasone furoate vs budesonide / formoterol was needed to identify the preferable FDC for asthma management.Study objective: to identify the preferable FDC of inhaled ...
N. L. Pogudina, E. G. Kosolapov, F. S. Kochenkov, A. V. Karaulov, N. L. Bondarenko, D. V. Blinov   +5 more
doaj   +1 more source

Revisiting Ferritin‐IgG Score to Predict Complete Biochemical Response in Autoimmune Hepatitis

Alimentary Pharmacology &Therapeutics, EarlyView.
The ferritin‐IgG score failed external validation in a large Spanish multicentre cohort. However, baseline IgG ≥ 1.89×ULN independently predicted both complete biochemical response and biochemical response (defined as transaminase normalization), identifying patients less likely to achieve timely remission with standard therapy.
Álvaro Díaz‐González, Bastian Engel, Manuel Hernández‐Guerra, Indhira Pérez‐Medrano, Beatriz Mateos, Rosa M. Morillas, Elena Gómez, Judith Gómez, Diana Horta, Isabel Conde, María Del Barrio, Ignasi Olivas, Ismael El Hajra, Mar Riveiro‐Barciela, Ana Barreira‐Díaz, Carmen López, Carmen Álvarez‐Navascúes, Manuel Rodríguez Perálvarez, Elmar Jaeckel, Richard Taubert, María‐Carlota Londoño   +20 more
wiley   +1 more source

Allergic contact dermatitis to enema used to treat inflammatory bowel disease

Revista da Sociedade Portuguesa de Dermatologia e Venereologia, 2023
Enemas are commonly used to treat inflammatory bowel disease. It is believed that allergic contact dermatitis (ACD) to enemas is underreported. We describe a case of a 55-year-old woman with non-specific proctitis.
Maria J. Guimarães, Ana G. Lopes, Teresa Pereira   +2 more
doaj  

Corticosteroid Exposure in Autoimmune Hepatitis: Early Toxicity, Cumulative Burden and Associations With Long‐Term Patient‐Reported Outcomes

Alimentary Pharmacology &Therapeutics, EarlyView.
In a patient‐reported cohort of 565 adults with autoimmune hepatitis, 96.6% reported corticosteroid‐related side effects within 6 months and long‐term toxicity increased with cumulative exposure. The findings support earlier tapering, toxicity monitoring, lower induction dosing when appropriate and selective budesonide use in carefully chosen non ...
Elizabeth Gentry, Mackenzie Woods, Kelsey Green, Nadia Blessing, Craig Lammert   +4 more
wiley   +1 more source