Results 41 to 50 of about 38,435 (236)

Increased FKBP51 in induced sputum cells of chronic obstructive pulmonary disease patients after therapy

European Journal of Medical Research, 2009
Objective Immunophilin FKBP51 assists polypeptide folding, participates in glucocorticoid actions and may play a role in glucocorticoid resistance. FKBP51 is altered in patients with asthma, but its role in chronic obstructive pulmonary disease (COPD ...
Holownia A, Mroz R M, Kolodziejczyk A, Chyczewska E, Braszko J J   +4 more
doaj   +1 more source

Brand and generic use of inhalation medication and frequency of switching in children and adults : a population-based cohort study [PDF]

, 2018
BACKGROUND: The expiration of patents of brand inhalation medications and the ongoing pressure on healthcare budgets resulted in a growing market for generics.
de Jongste, Johan C, Engelkes, Marjolein, Herings, Ron CM, Janssens, Hettie M, Kuiper, Josephine, Overbeek, Jetty A, Sturkenboom, Miriam CJM, van Blijderveen, Jan C, Verhamme, Katia   +8 more
core   +1 more source

Appropriate Medical Therapy Primarily Modifies Type 2 and Severity Biomarkers in Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Appropriate medical therapy (AMT) is first‐line treatment for patients with chronic rhinosinusitis (CRS). We evaluated inflammatory structure, treatment‐induced changes, and biomarker‐outcome associations in AMT‐managed patients. Methods Fifty‐one CRS patients were evaluated before and after AMT which included a combination of oral ...
Asher C. Park, Brooke N. Gleason, Eli Stein, Saied Ghadersohi, Atsushi Kato, Stephanie Shintani‐Smith, David B. Conley, Kevin C. Welch, Robert C. Kern, Bruce K. Tan   +9 more
wiley   +1 more source

Role of Erythromycin-Regulated Histone Deacetylase-2 in Benign Tracheal Stenosis

Canadian Respiratory Journal, 2020
Objective. This study aims to explore the role of erythromycin-regulated histone deacetylase-2 in benign tracheal stenosis. Methods. The rabbit model of tracheal stenosis was established. The rabbits were randomly divided into 8 groups.
Zhenjie Huang, Peng Wei, Luoman Gan, Tonghua Zeng, Caicheng Qin, Guangnan Liu   +5 more
doaj   +1 more source

Inhaled corticosteriod use and the risk of pneumonia and COPD exacerbations in the UPLIFT study [PDF]

, 2017
Rationale Unlike many other COPD studies, the 4-year UPLIFT trial permitted inhaled corticosteroid (ICS) use during run-in and treatment phases. This provided the opportunity to prospectively observe the continuing effects of ICS on respiratory events in
Morice, Alyn, Morice, Alyn H., Morjaria, Jaymin, Morjaria, Jaymin B., Rigby, Alan   +4 more
core   +1 more source

Effect of Budesonide Nasal Irrigation in Patients With Chronic Rhinosinusitis With Nasal Polyps Without Prior Sinus Surgery: A Randomized, Double‐Blind, Placebo‐Controlled Study

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background The indication for nasal irrigation with corticosteroids after sinus surgery in patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) is well established, as surgery facilitates distribution throughout the sinonasal cavity.
Juliana Sant'Ana, Isabela Pontes, Caio Floriano, Renato Rios, Marlos Cortez, Marcel Miyake   +5 more
wiley   +1 more source

Long-Term Oral Budesonide Use in Inflammatory Bowel Disease: Effects on Bone Mineral Density and Late-Onset Adverse Events

Diagnostics
Background/Objectives: Budesonide is a corticosteroid with low systemic bioavailability, commonly used for localized treatment in inflammatory bowel disease (IBD).
Tugce Eskazan, Oguz Kagan Bakkaloglu, Emre Durcan, Atilla Akpinar, Enes Ali Kurt, Ugur Onal, Yusuf Ziya Erzin, Ali Ibrahim Hatemi, Aykut Ferhat Celik   +8 more
doaj   +1 more source

The clinical effectiveness and cost-effectiveness of inhaler devices used in the routine management of chronic asthma in older children: a systematic review and economic evaluation [PDF]

, 2002
Background: This review examines the clinical effectiveness and cost-effectiveness of hand-held inhalers to deliver medication for the routine management of chronic asthma in children aged between 5 and 15 years.
Beverley, C., Lim, J.N.W., Peters, J., Smith, S., Stevenson, M.   +4 more
core   +1 more source

Cost Utility Analysis of Fluticasone Exhalation Delivery System Versus Budesonide Nasal Irrigation for Chronic Rhinosinusitis With Nasal Polyps

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is managed after sinus surgery with topical corticosteroids. Given limited distribution of nasal steroid sprays, patients have the option of either steroid nasal irrigation (SNI) or exhalation delivery system with fluticasone (EDS‐FLU).
Daniel Xiao, Martin J. Citardi, William C. Yao, Amber U. Luong   +3 more
wiley   +1 more source

Bilosomes and Biloparticles for the Delivery of Lipophilic Drugs: A Preliminary Study

Antioxidants, 2023
In this study, bile acid-based vesicles and nanoparticles (i.e., bilosomes and biloparticles) are studied to improve the water solubility of lipophilic drugs.
Maddalena Sguizzato, Francesca Ferrara, Nada Baraldo, Agnese Bondi, Annunziata Guarino, Markus Drechsler, Giuseppe Valacchi, Rita Cortesi   +7 more
doaj   +1 more source