Results 101 to 110 of about 3,231 (233)
Environmental Toxicology, Volume 39, Issue 12, Page 5309-5320, December 2024.ABSTRACT World Health Organization data indicate a continuous increase in melanoma incidence, with metastatic melanoma characterized by poor prognosis and drug resistance. The exploration of therapeutics derived from natural products remains an active area of in vitro research. The aim of this study was to determine the antitumor effects of picrasidine
Mu‐Kuei Shieu +5 more
wiley +1 more source
Molecular Ecology, Volume 33, Issue 14, July 2024.Abstract Cardiac glycosides are chemical defence toxins known to fatally inhibit the Na,K‐ATPase (NKA) throughout the animal kingdom. Several animals, however, have evolved target‐site insensitivity through substitutions in the otherwise highly conserved cardiac glycoside binding pocket of the NKA. The large milkweed bug, Oncopeltus fasciatus, shares a
Marlena Herbertz +5 more
wiley +1 more source
Resibufogenin suppresses colorectal cancer growth and metastasis through RIP3-mediated necroptosis
Journal of Translational Medicine, 2018 Background Necroptotic susceptibility is probably an intrinsic weakness of cancer. Here, we report that resibufogenin, a member of bufadienolide family, suppresses the growth and metastasis of colorectal cancer (CRC) through induction of necroptosis in ...
Qinrui Han +7 more
doaj +1 more source
Nephroprotective effect of the cardiotonic steroid ouabain [PDF]
, 2014 It has been shown that Na,K-ATPase (NKA) is a signal transducer. Our group described the anti-apoptotic effect of ouabain to the signaling function of NKA.
Burlaka, Ievgeniia
core +1 more source
Natriuretic Hormones, Endogenous Ouabain, and Related Sodium Transport Inhibitors
Frontiers in Endocrinology, 2014 The work of deWardener and colleagues stimulated longstanding interest in natriuretic hormones (NH). In addition to the atrial peptides (APs), the circulation contains unidentified physiologically-relevant NHs. One NH is controlled by the central nervous
John eHamlyn
doaj +1 more source
Potent nonopioid antinociceptive activity of telocinobufagin in models of acute pain in mice
PAIN Reports, 2019 . Introduction:. In recent decades, several researches have been conducted in search of new analgesics that do not present the side effects of opioids. In this context, animal venoms contain natural painkillers that have been used for the development of ...
Geissy I.M.C. Feitosa +14 more
doaj +1 more source
Insecticidal Bufadienolides from The Leaves of Kalanchoe daigremontiana (Crassulaceae) [PDF]
, 2010 Kalanchoe is the biggest genera of Crassulaceae family and distributed in tropical and subtropical regions. This genera is found to be a rich source of biologically active natural products such as triterpenes, flavonoids and steroids.
Fajriah, Sofa +4 more
core +1 more source
A környezet hatása kétéltűek kémiai védekezésének változatosságára [PDF]
, 2018 A fenotípusos plaszticitás, tehát a genotípus azon képessége, hogy különböző környezetekben különböző fenotípusokat hozzon létre, általánosan elterjedt az élővilágban.
Üveges, Bálint
core +3 more sources
Chemical Evidence for Dietary Toxin Sequestration in the Asian Snake \u3ci\u3eRhabdophis tigrinus\u3c/i\u3e [PDF]
, 2006 Rhabdophis tigrinus (Colubridae: Natricinae) is an oviparous, bufophagous (toad-eating) snake from eastern Asia that possesses defensive integumentary glands on the neck known as nuchal glands. These glands are used in antipredator displays and typically
Hutchinson, Deborah A.
core +1 more source
Marinobufagenin Inhibits Neutrophil Migration and Proinflammatory Cytokines
Journal of Immunology Research, 2019 Cardiotonic steroids, such as ouabain and digoxin, are known to bind to Na+/K+-ATPase and to promote several biological activities, including anti-inflammatory activity.
Deyse C. M. Carvalho +7 more
doaj +1 more source