Anti-Trypanosomal Bufadienolides from the Oocytes of the Toad Rhinella alata (Anura, Bufonidae) [PDF]
Molecules, 2023 Amphibians are widely known as a prolific source of bioactive metabolites. In this work, we isolated and characterized compounds with antiparasitic activity from the oocytes of the toad Rhinella alata collected in Panama.
Candelario Rodriguez +6 more
doaj +2 more sources
Toad venom-derived bufadienolides and their therapeutic application in prostate cancers: Current status and future directions [PDF]
Frontiers in Chemistry, 2023 Cancer is the second leading cause of death worldwide. Specially, the high incidence rate and prevalence of drug resistance have rendered prostate cancer (PCa) a great threat to men’s health.
Qingmei Ye +4 more
doaj +2 more sources
Development and validation of a spectrophotometric method for the quantification of total bufadienolides in samples of toad glandular secretions [PDF]
Journal of Venomous Animals and Toxins including Tropical DiseasesBackground: Bufadienolides are the main secondary metabolites found in the paratoid gland secretions (PGS) of toads of the Bufonidae family. These compounds are considered the main bioactive components of PGS.
Elcio Daniel Sousa Barros +4 more
doaj +2 more sources
3α-Hydroxybufadienolides in Bufo gallbladders: structural insights and biotransformation [PDF]
Natural Products and BioprospectingBufadienolides, naturally occurring steroids primarily found in toads, have garnered attention for their pharmacological properties and ecological significance.
Li-Jun Ruan +2 more
doaj +2 more sources
Isolation, Identification and Chemical Modification of Bufadienolides from Bufo melanostictus Schneider and Their Cytotoxic Activities against Prostate Cancer Cells [PDF]
MoleculesThe traditional Chinese medicine toad venom (Venenum bufonis) has been extensively used to treat various diseases, including cancers, in China and other Southeast Asian countries.
Qingmei Ye +4 more
doaj +2 more sources
Bufadienolides from Chansu Injection Synergistically Enhances the Antitumor Effect of Erlotinib by Inhibiting the KRAS Pathway in Pancreatic Cancer [PDF]
PharmaceuticalsBackground and Objectives: The Chansu injection (CSI), a sterile aqueous solution derived from Chansu, is applied in clinical settings to support antitumor and anti-radiation treatments.
Yanli Guo +8 more
doaj +2 more sources
Bioactive Compounds from Kalanchoe Genus Potentially Useful for the Development of New Drugs [PDF]
Life, 2023 The genus Kalanchoe Adans. (Crassulaceae) is native to Madagascar and comprises 145 species, being naturalized in the tropics and cultivated worldwide.
Luana Beatriz dos Santos Nascimento +2 more
doaj +2 more sources
Bufadienolide Penetration Through the Skin Membrane and Antiaging Properties of Kalanchoe spp. Juices in Dermal Applications [PDF]
MoleculesSkin aging is accelerated by inflammation processes generated by oxidative stress and external factors such as UV radiation. Plants belonging to the genus Kalanchoe that are rich sources of antioxidants could potentially strengthen the skin barrier if ...
Anna Hering +6 more
doaj +2 more sources
Comparative MS- and NMR-Based Metabolome Mapping of Egyptian Red and White Squill Bulbs F. Liliaceae and in Relation to Their Cytotoxic Effect [PDF]
Plants, 2023 Urginea maritima L. (squill) species is widely spread at the Mediterranean region as two main varieties, i.e., white squill (WS) and red squill (RS), that are recognized for several health potentials.
Omar M. Khattab +5 more
doaj +2 more sources
New Bufadienolides Isolated from the Roots of Kalanchoe daigremontiana (Crassulaceae)
Molecules, 2016 An aqueous extract from the roots of Kalanchoe daigremontiana turned out to be a rich source of bufadienolides. The existing literature data relate mainly to the aerial parts of Kalanchoe but there is no information about the metabolic profile of the ...
Barbara Moniuszko-Szajwaj +2 more
exaly +3 more sources