Results 11 to 20 of about 1,623 (201)
Journal of Arrhythmia, 2017 Classically derived from toad venom, bufadienolides are a group of cardioactive steroids with properties similar to digoxin. Some traditional Chinese medications, including several aphrodisiacs, contain bufadienolides.
Maxwell Bressman +3 more
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Química Nova, 2013 Eight bufadienolides were successfully isolated and purified from ChanSu by high-speed counter-current chromatography (HSCCC) combined with preparative HPLC (prep-HPLC).
Jialian Li +6 more
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Molecular structure-affinity relationship of bufadienolides and human serum albumin in vitro and molecular docking analysis. [PDF]
PLoS ONE, 2015 The development of bufadienolides as anti-tumor agents is limited due to poor pharmacokinetic properties regarding drug half-lives and toxicity in vivo. These serious factors might be improved by increasing the drug/albumin-binding ratio.
Jing Zhou +6 more
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In Vitro Cytotoxicity Induced by the Bufadienolides 1α,2α-Epoxyscillirosidine and Lanceotoxin B on Rat Myocardial and Mouse Neuroblastoma Cell Lines [PDF]
Toxins, 2019 Consumption of bufadienolide-containing plants are responsible for many livestock mortalities annually. Bufadienolides are divided into two groups; non-cumulative bufadienolides and cumulative bufadienolides.
Danielle Henn +2 more
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Biosynthesis of the Bufadienolide Ring of Scillirosid in Scilla maritima
Zeitschrift für Naturforschung C, 1984 Abstract Administration of sodium [1,2-14C2]oxaloacetate and sodium [1-14C] acetate to Scilla maritima plants yielded labelled scillirosid. Asystematic degradation of scillirosid indicated that the 2 -pyrone ring of the bufadienolide is formed by the condensation of a pregnane derivative (derived from mevalonic acid via squalene) and ...
L R, Galagovsky +3 more
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In-silico analysis of bufadienolides as potential inhibitors of Trypanosoma nucleoside hydrolase
Chemical Physics Impact, 2023 Trypanosomiasis is one of the neglected tropical diseases which curtails the productivity of the victim and causes mortality in extreme cases. Non-availability of vaccines, low therapeutic index of trypanocidal drugs and development of resistance lead to
Shalaka R. Sawant +6 more
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Comprehensive Analysis of Bufadienolide and Protein Profiles of Gland Secretions from Medicinal Bufo Species [PDF]
ToxinsToad Venom (TV) is the dried product of toxic secretions from Bufo bufo gargarizans Cantor (BgC) or B. melanostictus Schneider (BmS). Given the increasing medical demand and the severe depletion of wild toads, a number of counterfeit TVs appeared on the ...
Yunge Fang +7 more
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Potential Health Risks Posed by Plant-Derived Cumulative Neurotoxic Bufadienolides in South Africa [PDF]
Molecules, 2016 Bufadienolide-type cardiac glycosides have a worldwide distribution and are mainly synthesized by plants, but there are also animal sources. In South Africa, members of three genera of the Crassulaceae (Cotyledon, Tylecodon and Kalanchoe) cause a unique ...
Christo Botha
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Synthetic and Structure-Activity Relationship of Insecticidal Bufadienolides [PDF]
Natural Product Communications, 2014 A new synthetic analog of bufadienolide, methyl isobryophyllinate A ( 1 ), and a known synthetic analog, methyl isobersaldegenate-1,3,5-orthoacetate ( 2 ), were obtained by methanolysis of bryophyllin A ( 3 ) and bersaldegenin-1,3,5-orthoacetate ( 5 ) in
Ace Tatang Hidayat +5 more
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Frontiers in Genetics, 2022 Bufo bufo gargarizans Cantor are precious medicinal animals in traditional Chinese medicine (TCM). Bufadienolides as the major pharmacological components are generated from the venomous glands of B. bufo gargarizans.
Guangli Li +12 more
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