From Traditional Use to Molecular Mechanisms: A Bioinformatic and Pharmacological Review of the Genus Kalanchoe with In Silico Evidence [PDF]
BioTechThe genus Kalanchoe (Crassulaceae) comprises approximately 125 species of succulents distributed across Madagascar, Africa, Arabia, Australia, Southeast Asia, and tropical America.
Cristián Raziel Delgado-González +8 more
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Endogenous Bufadienolides, Fibrosis and Preeclampsia
Cardiology Research and Practice, 2019 Frequency of preeclampsia has no tendency to decrease, and it still takes the leading position in the structure of maternal mortality and morbidity worldwide.
Vitaliy A. Reznik +4 more
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Comprehensive Analysis of Bufadienolide and Protein Profiles of Gland Secretions from Medicinal Bufo Species [PDF]
ToxinsToad Venom (TV) is the dried product of toxic secretions from Bufo bufo gargarizans Cantor (BgC) or B. melanostictus Schneider (BmS). Given the increasing medical demand and the severe depletion of wild toads, a number of counterfeit TVs appeared on the ...
Yunge Fang +7 more
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Circular Dichroism of Bufadienolides [PDF]
Croatica Chemica Acta, 1985 With the help of PMO theory a non-empirical sector rule has been derived for the n ~ 1t5* band CD (around 260 nm) of the pentadienolide chromophore of steroidal bufadienolides.
Brian Green +5 more
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Insecticidal Bufadienolides from The Leaves of Kalanchoe daigremontiana (Crassulaceae) [PDF]
Jurnal Ilmu Dasar, 2010 Kalanchoe is the biggest genera of Crassulaceae family and distributed in tropical and subtropical regions. This genera is found to be a rich source of biologically active natural products such as triterpenes, flavonoids and steroids.
Wawan Hermawan +4 more
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Novel Strategies for Solubility and Bioavailability Enhancement of Bufadienolides
Molecules, 2021 Toad venom contains a large number of bufadienolides, which have a variety of pharmacological activities, including antitumor, cardiovascular, anti-inflammatory, analgesic and immunomodulatory effects.
Huili Shao +6 more
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Frontiers in Genetics, 2022 Bufo bufo gargarizans Cantor are precious medicinal animals in traditional Chinese medicine (TCM). Bufadienolides as the major pharmacological components are generated from the venomous glands of B. bufo gargarizans.
Guangli Li +12 more
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Insects, 2021 Natural history collections provide an invaluable basis for systematics, ecology, and conservation. Besides being an important source of DNA, museum specimens may also contain a plethora of natural products. Especially, dried insect collections represent
Andreas Berger +4 more
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Resibufogenin and cinobufagin activate central neurons through an ouabain-like action. [PDF]
PLoS ONE, 2014 Cinobufagin and resibufogenin are two major effective bufadienolides of Chan su (toad venom), which is a Chinese medicine obtained from the skin venom gland of toads and is used as a cardiotonic and central nervous system (CNS) respiratory agent, an ...
Ze-Jun Wang +2 more
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Molecular structure-affinity relationship of bufadienolides and human serum albumin in vitro and molecular docking analysis. [PDF]
PLoS ONE, 2015 The development of bufadienolides as anti-tumor agents is limited due to poor pharmacokinetic properties regarding drug half-lives and toxicity in vivo. These serious factors might be improved by increasing the drug/albumin-binding ratio.
Jing Zhou +6 more
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