Results 21 to 30 of about 1,623 (201)
Cinobufagin Directly Targets PDE4D to Disrupt Fibroblast-Dendritic Cell Crosstalk in Atopic Dermatitis. [PDF]
Adv Sci (Weinh)Single‐cell RNA sequencing revealed that MIF signaling drives inflammatory fibroblastmyeloid cell crosstalk in atopic dermatitis. Cinobufagin, a potent PDE4D inhibitor, suppresses MIF and reduces inflammation by restoring the cAMP/PKA/CREB pathway. Genetic knockout validates PDE4D as a key driver and promising therapeutic target for atopic dermatitis ...
Li S +14 more
europepmc +2 more sources
Insects, 2021 Natural history collections provide an invaluable basis for systematics, ecology, and conservation. Besides being an important source of DNA, museum specimens may also contain a plethora of natural products. Especially, dried insect collections represent
Andreas Berger +4 more
doaj +1 more source
Frontiers in Chemistry, 2023 Cancer is the second leading cause of death worldwide. Specially, the high incidence rate and prevalence of drug resistance have rendered prostate cancer (PCa) a great threat to men’s health.
Qingmei Ye +4 more
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Bufadienolides - natural, biologically active compounds for medicines and cosmetics. A review. [PDF]
, 2023 Toad skin secretions are a rich source of various biologically active compounds, such as alkaloids, bufadienolides, biogenic amines, or peptides. Also plants from Hyacinthaceae and Crassulaceae can be a potent source of these groups of molecules.
Szymczak, Kamil, Bonikowski, Radosław
core +1 more source
Antiproliferative bufadienolides from the bulbs of Drimia altissima [PDF]
, 2021 The bulbs of the South African Drimia altissima (Asparagaceae or Hyacinthaceae sensu APGII) have yielded a range of previously undescribed bufadienolides, drimianins A–G (1–7), the known bufadienolides bovogenin A (8), 3β-O-β-d-glucopyranosylbovogenin A (
Langat, Moses +6 more
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Resibufogenin and cinobufagin activate central neurons through an ouabain-like action. [PDF]
PLoS ONE, 2014 Cinobufagin and resibufogenin are two major effective bufadienolides of Chan su (toad venom), which is a Chinese medicine obtained from the skin venom gland of toads and is used as a cardiotonic and central nervous system (CNS) respiratory agent, an ...
Ze-Jun Wang +2 more
doaj +1 more source
Antimicrobial activity of skin secretions isolated from Indian toad, Bufo melanostictus Schneider 1799 [PDF]
, 2007 Amphibians like toads have been known to secrete antimicrobial secretions outside their body into their environments, through skin pores and parotid glands.
Rajshekhar V. Hippargi +3 more
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Bioactive Compounds from Kalanchoe Genus Potentially Useful for the Development of New Drugs
Life, 2023 The genus Kalanchoe Adans. (Crassulaceae) is native to Madagascar and comprises 145 species, being naturalized in the tropics and cultivated worldwide.
Luana Beatriz dos Santos Nascimento +2 more
doaj +1 more source
Molecules, 2022 Kalanchoe species are succulents with anti-inflammatory, antioxidant, and analgesic properties, as well as cytotoxic activity. One of the most popular species cultivated in Europe is Kalanchoe daigremontiana Raym.-Hamet and H. Perrier.
Justyna Stefanowicz-Hajduk +6 more
doaj +1 more source
Pharmaceuticals, 2020 The subgenus Bryophyllum includes about 25 plant species native to Madagascar, and is widely used in traditional medicine worldwide. Different formulations from Bryophyllum have been employed for the treatment of several ailments, including infections ...
Pascual García-Pérez +3 more
doaj +1 more source