Enhanced Cytotoxic Effects of Arenite in Combination with Active Bufadienolide Compounds against Human Glioblastoma Cell Line U-87 [PDF]
Molecules, 2022 The cytotoxicity of a trivalent arsenic derivative (arsenite, AsIII) combined with arenobufagin or gamabufotalin was evaluated in human U-87 glioblastoma cells.
Bo Yuan +11 more
doaj +6 more sources
Bufadienolide Penetration Through the Skin Membrane and Antiaging Properties of Kalanchoe spp. Juices in Dermal Applications [PDF]
MoleculesSkin aging is accelerated by inflammation processes generated by oxidative stress and external factors such as UV radiation. Plants belonging to the genus Kalanchoe that are rich sources of antioxidants could potentially strengthen the skin barrier if ...
Anna Hering +6 more
doaj +3 more sources
Does the Glucocorticoid Stress Response Make Toads More Toxic? An Experimental Study on the Regulation of Bufadienolide Toxin Synthesis. [PDF]
Integr Org Biol, 2023 Chemical defense is a crucial component of fitness in many organisms, yet the physiological regulation of defensive toxin synthesis is poorly understood, especially in vertebrates.
Üveges B +7 more
europepmc +5 more sources
Bufadienolides originated from toad source and their anti-inflammatory activity [PDF]
Frontiers in Pharmacology, 2022 Bufadienolide, an essential member of the C-24 steroid family, is characterized by an α-pyrone positioned at C-17. As the predominantly active constituent in traditional Chinese medicine of Chansu, bufadienolide has been prescribed in the treatment of ...
Denglang Zou +12 more
doaj +2 more sources
Cinobufagin as a Potential Intervention Against Liver Cancer—A Comprehensive Review [PDF]
PharmaceuticalsLiver cancer remains a significant global health challenge, with hepatocellular carcinoma (HCC) being the most prevalent form. Despite advancements in treatment, high recurrence rates and the limited efficacy of conventional therapies highlight the need ...
Nicole Simone de Lima Coelho +10 more
doaj +2 more sources
Anti-Trypanosomal Bufadienolides from the Oocytes of the Toad Rhinella alata (Anura, Bufonidae) [PDF]
Molecules, 2023 Amphibians are widely known as a prolific source of bioactive metabolites. In this work, we isolated and characterized compounds with antiparasitic activity from the oocytes of the toad Rhinella alata collected in Panama.
Candelario Rodriguez +6 more
doaj +2 more sources
Alterations in gut microbiota and metabolomic profiles in acute stroke: insights into brain–gut axis dysregulation [PDF]
Frontiers in MicrobiologyIntroductionAcute stroke (AS) is a major public health issue globally, exhibiting high morbidity, disability rate, and mortality. Emerging research has demonstrated the critical roles of gut microbiota and its metabolites in pathogenesis, recovery, and ...
Jiajing Chen +4 more
doaj +2 more sources
Accidental bufotoxin intoxication: Arenobufagin identification by liquid chromatography coupled to mass spectrometry [PDF]
Practical Laboratory MedicineBackground: Since ancient times, poisoning, even serious poisoning, has been known to occur during nature walks. Intentional or unintentional ingestion of toxins of animal origin is one of the possible causes of poisoning.
Alessandro Bonari +9 more
doaj +2 more sources
Repurposing of Bryophyllum pinnatum for dysmenorrhea treatment: a systematic scoping review and case series. [PDF]
Front Pharmacol, 2023 Dysmenorrhea affects women throughout their reproductive years but there has been a lack of effective and well-tolerated treatment options. Pain symptoms mainly result from inflammatory processes and increased contractile activity in the myometrium.
Zurfluh L +3 more
europepmc +3 more sources
Structurally diverse bufadienolides from the skins of Bufo bufo gargarizans and their cytotoxicity [PDF]
Scientific ReportsNatural products, with their extensive chemical diversity, distinctive biological activities, and vast reservoirs, provide a robust foundation for advancing cancer therapeutics.
Lingjie Meng +7 more
doaj +2 more sources