Bioinspired Synthesis of Twin abeo-Steroids Bufogargarizins A and B via a Divergent Intramolecular Aldol Addition Reaction. [PDF]
Angew Chem Int Ed EnglTwin natural products. This manuscript describes a concise biomimetic synthesis of twin abeo‐steroids bufogargarizins A and B with an unusual [7.5.6.5] and [5.7.6.5] skeletons in 19 steps (LLS). The described synthetic approach features the application of a bioinspired regiodivergent intramolecular aldol addition reaction and a selective singlet oxygen‐
Surma ZJ +7 more
europepmc +3 more sources
You are what your ancestors ate: retained bufadienolide resistance in the piscivorous water cobra Naja annulata (Serpentes: Elapidae) [PDF]
Herpetological Journal, 2023 Predators exploiting chemically defended prey are generally resistant to prey toxins. However, toxin resistance usually incurs a fitness cost and is therefore often lost when no longer needed.
Fletcher, Jess +2 more
core +2 more sources
Synthesis of Bufadienolide Cinobufagin via Late-Stage Singlet Oxygen Oxidation/Rearrangement Approach. [PDF]
Org LettThis manuscript describes a concise synthesis of cinobufagin, a natural steroid of the bufadienolide family, from readily available dehydroepiandrosterone (DHEA), as well as its α5-epimer derived from 3-epi-andosterone.
Tichvon C +3 more
europepmc +2 more sources
Frontiers in Ecology and Evolution, 2023 Anthropogenic environmental change, including climate change and urbanization, results in warmer temperatures in both terrestrial and aquatic habitats and changes in community assemblages including invasive species introductions, among many other ...
Dillon J. Monroe +4 more
doaj +1 more source
Ecology and Evolution, 2021 Cane toads are highly toxic bufonids invasive in several locations throughout the world. Although physiological changes and effects on native predators for Australian populations have been well documented, Florida populations have received little ...
Steven T. Gardner +5 more
doaj +1 more source
Bryophyllum pinnatum Compounds Inhibit Oxytocin-Induced Signaling Pathways in Human Myometrial Cells
Frontiers in Pharmacology, 2021 Bryophyllum pinnatum has been used in the treatment of premature labor, first in anthroposophic hospitals and, recently, in conventional settings as an add-on medication. In vitro work with hTERT human myometrial cells showed that B.
Stefanie Santos +7 more
doaj +1 more source
Molecular structure-affinity relationship of bufadienolides and human serum albumin in vitro and molecular docking analysis. [PDF]
PLoS ONE, 2015 The development of bufadienolides as anti-tumor agents is limited due to poor pharmacokinetic properties regarding drug half-lives and toxicity in vivo. These serious factors might be improved by increasing the drug/albumin-binding ratio.
Jing Zhou +6 more
doaj +1 more source
Evaluating the cancer therapeutic potential of cardiac glycosides [PDF]
, 2014 Cardiac glycosides, also known as cardiotonic steroids, are a group of natural products that share a steroid-like structure with an unsaturated lactone ring and the ability to induce cardiotonic effects mediated by a selective inhibition of the Na(+)/K(+)
Burgos Morón, Estefanía +5 more
core +7 more sources
Ku80 cooperates with CBP to promote COX-2 expression and tumor growth. [PDF]
, 2015 Cyclooxygenase-2 (COX-2) plays an important role in lung cancer development and progression. Using streptavidin-agarose pulldown and proteomics assay, we identified and validated Ku80, a dimer of Ku participating in the repair of broken DNA double ...
Chen, Yiming +23 more
core +6 more sources
Resibufogenin and cinobufagin activate central neurons through an ouabain-like action. [PDF]
PLoS ONE, 2014 Cinobufagin and resibufogenin are two major effective bufadienolides of Chan su (toad venom), which is a Chinese medicine obtained from the skin venom gland of toads and is used as a cardiotonic and central nervous system (CNS) respiratory agent, an ...
Ze-Jun Wang +2 more
doaj +1 more source