Results 31 to 40 of about 3,231 (233)

Bufalin Inhibits the PI3K/AKT Pathway by Targeting GTF3C4 to Impede Breast Cancer Progression. [PDF]

Adv Sci (Weinh)
Mechanisms of Bufalin‐Mediated Intervention in Breast Cancer. ABSTRACT Breast cancer incidence is rising globally, presenting challenges such as treatment side effects and drug resistance. Bufalin is a bufadienolides compound with potential anti‐cancer effects. This study shows that bufalin inhibits malignant proliferation of MDA‐MB‐231 and MCF‐7 cells
Guo S, Chen X, Wang H, Zhou J, Lu P, Liu J, Chai K, Zhang J, Yang S, Lu S, Gao Y, Jin Z, Tao X, Hu Z, Li Q, Wu J.   +15 more
europepmc   +2 more sources

Bersaldegenin-1,3,5-orthoacetate induces caspase-independent cell death, DNA damage and cell cycle arrest in human cervical cancer HeLa cells

Pharmaceutical Biology, 2021
Context Bufadienolide compounds occur in many plants and animal species and have strong cardiac and anti-inflammatory properties. The compounds have been recently investigated for cytotoxic and antitumor activity.
Justyna Stefanowicz-Hajduk, Magdalena Gucwa, Barbara Moniuszko-Szajwaj, Anna Stochmal, Anna Kawiak, J. Renata Ochocka   +5 more
doaj   +1 more source

Uncovering the antimalarial potential of toad venoms through a bioassay-guided fractionation process

International Journal for Parasitology: Drugs and Drug Resistance, 2022
Malaria remains to date one of the most devastating parasitic diseases worldwide. The fight against this disease is rendered more difficult by the emergence and spread of drug-resistant strains. The need for new therapeutic candidates is now greater than
Mathilde Wells, Mathieu Fossépré, Stéphanie Hambye, Mathieu Surin, Bertrand Blankert   +4 more
doaj   +1 more source

Mechanisms of Anti-Inflammatory and Antioxidant Activity of Extracts of Selected South African Celastraceae and Crassulaceae Plant Species With Known Efficacy Against Bovine Mastitis Bacterial Pathogens. [PDF]

Scientifica (Cairo)
Inflammation, a complicated reaction to microbial infection or injury, promotes healing under normal circumstances. However, when it becomes uncontrolled, it can result in cell damage or even death. Inflammation is a major feature of infectious mastitis in cattle as well as in humans, with substantial health, welfare and financial challenges ...
Ogbuadike EC, Nkadimeng SM, Khunoana ET, Igwe CC, Qekwana DN, Petzer IM, McGaw LJ.   +6 more
europepmc   +2 more sources

Electrophysiologic similarities of overdose between digoxin and bufadienolides found in a Chinese aphrodisiac

Journal of Arrhythmia, 2017
Classically derived from toad venom, bufadienolides are a group of cardioactive steroids with properties similar to digoxin. Some traditional Chinese medications, including several aphrodisiacs, contain bufadienolides.
Maxwell Bressman, Daniel Repplinger, William Slater, Mitchell Patt   +3 more
doaj   +1 more source

Spatial variation of epoxyscillirosidine concentrations in Moraea pallida (yellow tulp) in South Africa [PDF]

, 2013
Moraea pallida (yellow tulp) poisoning is economically the most important intoxication of livestock in South Africa. Poisoning varies according to locality, climatic conditions and growth stage of the plant.
Botha, Christo J., Coetser, Heleen, Labuschagne, Leonie, Schultz, Rowena A., Van Der Merwe, Deon   +4 more
core   +3 more sources

In Vitro Cytotoxicity Induced by the Bufadienolides 1α,2α-Epoxyscillirosidine and Lanceotoxin B on Rat Myocardial and Mouse Neuroblastoma Cell Lines

Toxins, 2019
Consumption of bufadienolide-containing plants are responsible for many livestock mortalities annually. Bufadienolides are divided into two groups; non-cumulative bufadienolides and cumulative bufadienolides.
Danielle Henn, Annette Venter, Christo Botha   +2 more
doaj   +1 more source

Phytochemical investigations of three Rhodocodon (Hyacinthaceae Sensu APG II) species [PDF]

, 2017
The genus Rhodocodon (Hyacinthaceae sensu APG II) is endemic to Madagascar and its phytochemistry has not been described previously. The phytochemistry of three species in this genus has been investigated and eight compounds, including three ...
Alaa Alqahtani, Andrius Jaksevicius, Dagne E., Dulcie A. Mulholland, Elizabeth I. Opara, Jackie L. Andriantiana, Moses K. Langat, Pfosser M., Sianne Schwikkard, Tachibana M., Walter Knirsch, Wolfgang Wetschnig   +11 more
core   +2 more sources

Tadpole Skin Secretions, Not Food or Temperature, Mediate Costly Cannibal-Induced Plasticity in Invasive Cane Toad Hatchlings. [PDF]

Ecol Evol
Hatchlings of invasive cane toads respond to the risk of cannibalism by accelerating development but experience significant negative carry‐over effects on fitness in the tadpole stage. Our experiments demonstrate that this hatchling response is induced by chemicals located in the skin of older cannibalistic tadpoles. This response is unique to cannibal
Crossland MR, Shine R, DeVore JL.
europepmc   +2 more sources

The chemistry and biological activity of the Hyacinthaceae [PDF]

, 2013
Covering: 1914 to 2012The Hyacinthaceae (sensu APGII), with approximately 900 species in about 70 genera, can be divided into three main subfamilies, the Hyacinthoideae, the Urgineoideae and the Ornithogaloideae, with a small fourth subfamily the ...
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core   +1 more source