Cinobufagin Directly Targets PDE4D to Disrupt Fibroblast–Dendritic Cell Crosstalk in Atopic Dermatitis [PDF]
Advanced ScienceAtopic dermatitis (AD) is a chronic inflammatory skin disease driven by immune dysregulation and Th2‐dominant inflammation. This study identifies phosphodiesterase 4D (PDE4D) as a key regulator of AD pathogenesis and a potential therapeutic target ...
Shicong Li +14 more
doaj +3 more sources
19-Hydroxy-bufalin, a major bufadienolide isolated from the parotoid gland secretions of the Panamanian endemic toad Rhinella centralis (Bufonidae), inhibits the growth of Trypanosoma cruzi [PDF]
Toxicon, 2020 American trypanosomiasis is a parasitic neglected disease, responsible for the death of approximately 10,000 people every year. Amphibians are recognized for producing in their cutaneous glands substances with pharmacological potential against a variety ...
Candelario Rodriguez +2 more
exaly +4 more sources
Chinese Medicine, 2022 Background To adapt to life on land, Asiatic toads (Bufo gargarizans) must remodel their bodies and refine their chemical defenses in water. The full scope of the mechanisms underlying these processes has yet to be revealed.
Bo Sun +9 more
doaj +2 more sources
MALDI-MS argininyl bufadienolide esters fingerprint from parotoid gland secretions of Rhinella arenarum : age, gender and seasonal variation [PDF]
Journal of Mass Spectrometry, 2018 In many amphibians, the granular glands can be grouped in special regions forming macroglands. This is the case of toads, characterized by the presence of a pair of parotoid macroglands, strategically located to give protection by poison release in case ...
Erra Balsells, Rosa +4 more
core +2 more sources
Comprehensive Analysis of Bufadienolide and Protein Profiles of Gland Secretions from Medicinal Bufo Species [PDF]
ToxinsToad Venom (TV) is the dried product of toxic secretions from Bufo bufo gargarizans Cantor (BgC) or B. melanostictus Schneider (BmS). Given the increasing medical demand and the severe depletion of wild toads, a number of counterfeit TVs appeared on the ...
Yunge Fang +7 more
doaj +2 more sources
Development and validation of a spectrophotometric method for the quantification of total bufadienolides in samples of toad glandular secretions [PDF]
Journal of Venomous Animals and Toxins including Tropical DiseasesBackground: Bufadienolides are the main secondary metabolites found in the paratoid gland secretions (PGS) of toads of the Bufonidae family. These compounds are considered the main bioactive components of PGS.
Elcio Daniel Sousa Barros +4 more
doaj +2 more sources
An In Vitro Anticancer, Antioxidant, and Phytochemical Study on Water Extract of Kalanchoe daigremontiana Raym.-Hamet and H. Perrier [PDF]
Molecules, 2022 Kalanchoe species are succulents with anti-inflammatory, antioxidant, and analgesic properties, as well as cytotoxic activity. One of the most popular species cultivated in Europe is Kalanchoe daigremontiana Raym.-Hamet and H. Perrier.
Justyna Stefanowicz-Hajduk +6 more
doaj +2 more sources
Journal of Traditional Chinese Medical Sciences, 2019 Objective: To explore the effects of cinobufagin (CBF), an active component of toad venom (Bufo bufo gargarizans CANTOR), on the proliferation and apoptosis of PC3 human prostate cancer cells in vitro and preliminarily investigate the mechanism of CBF in
Tianli Niu +9 more
doaj +2 more sources
Harnessing Arsenic Derivatives and Natural Agents for Enhanced Glioblastoma Therapy. [PDF]
CellsGlioblastoma (GBM) is the most common and lethal intracranial tumor in adults. Despite advances in the understanding of the molecular events responsible for disease development and progression, survival rates and mortality statistics for GBM patients ...
Yuan B, Kikuchi H.
europepmc +3 more sources
Correction: Gamabufotalin, a bufadienolide compound from toad venom, suppresses COX-2 expression through targeting IKKβ/NF-κB signaling pathway in lung cancer cells [PDF]
Molecular Cancer, 2023 Zhenlong Yu +17 more
doaj +2 more sources