Results 41 to 50 of about 3,231 (233)

Beneficent and maleficent effects of cations on bufadienolide binding to Na+,K+-ATPase

open access: yesbioRxiv, 2020
Kinetic properties and crystal structures of the Na+,K+-ATPase in complex with cardiotonic steroids (CTS) revealed significant differences between CTS subfamilies (Laursen et al., 2015): beneficial effects of K+ on bufadienolide binding strongly ...
L. K. Ladefoged   +2 more
semanticscholar   +1 more source

Endogenous Bufadienolides, Fibrosis and Preeclampsia

open access: yesCardiology Research and Practice, 2019
Frequency of preeclampsia has no tendency to decrease, and it still takes the leading position in the structure of maternal mortality and morbidity worldwide. In this review, we present the “fibrotic concept” of the etiology and pathogenesis of preeclampsia which involves system consisting of Na/K-ATPase and its endogenous ligands including ...
Vitaliy A. Reznik   +4 more
openaire   +4 more sources

Exposure to Batrachochytrium dendrobatidis affects chemical defences in two anuran amphibians, Rana dalmatina and Bufo bufo

open access: yesBMC Ecology and Evolution, 2021
Background Batrachochytrium dendrobatidis (Bd) is the causative agent of chytridiomycosis, one of the major causes of worldwide amphibian biodiversity loss.
János Ujszegi   +9 more
doaj   +1 more source

First serine protease inhibitor isolated from Rhinella schneideri poison

open access: yesJournal of Venomous Animals and Toxins including Tropical Diseases, 2015
Background Toad secretions are a source of molecules with potential biotechnological application on a wide spectrum of diseases. Toads from theRhinella family have two kinds of poisonous glands, namely granular and mucous glands. Rhinella schneideritoads
Priscila Y T Shibao   +3 more
doaj   +1 more source

Insect Collections as an Untapped Source of Bioactive Compounds—Fireflies (Coleoptera: Lampyridae) and Cardiotonic Steroids as a Proof of Concept

open access: yesInsects, 2021
Natural history collections provide an invaluable basis for systematics, ecology, and conservation. Besides being an important source of DNA, museum specimens may also contain a plethora of natural products. Especially, dried insect collections represent
Andreas Berger   +4 more
doaj   +1 more source

Cardiac glycosides and breast cancer risk: A systematic review and meta-analysis of observational studies [PDF]

open access: yes, 2017
Cardiac glycosides are phytoestrogens and have been linked to the risk of estrogen sensitive cancers such as uterus cancer. However, the association between use of cardiac glycosides and risk of breast cancer remains unclear.
Ahern   +26 more
core   +1 more source

Dissolved organic matter produced by Thalassiosira pseudonana [PDF]

open access: yes, 2014
Author Posting. © The Author(s), 2014. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution.
Kido Soule, Melissa C.   +2 more
core   +1 more source

Rhinovirus inhibition by bufadienolides.

open access: yesChemical and Pharmaceutical Bulletin, 1988
An evaluation of thirty-four bufadienolides and two related cardenolides against a series of rhinoviruses in vitro has been completed. Most of the bufadienolides were found to display some inhibitory activity. Scillarenin and 3-O-[N-(tert-butoxycarbonyl)hydrazido]succinylbufalin were found to be the most active with chemotherapeutic indices of 32 and ...
Y, Kamano   +4 more
openaire   +3 more sources

Chemical defense of toad tadpoles under risk by four predator species

open access: yesEcology and Evolution, 2019
Many organisms use inducible defenses as protection against predators. In animals, inducible defenses may manifest as changes in behavior, morphology, physiology, or life history, and prey species can adjust their defensive responses based on the ...
Bálint Üveges   +7 more
doaj   +1 more source

Bufotalin Suppresses Proliferation and Metastasis of Triple-Negative Breast Cancer Cells by Promoting Apoptosis and Inhibiting the STAT3/EMT Axis

open access: yesMolecules, 2023
Triple-negative breast cancer (TNBC) is a highly aggressive type of breast cancer and has a poor prognosis. As standardized TNBC treatment regimens cause drug resistance and tumor recurrence, the development of new TNBC treatment strategies is urgently ...
So Jin Park, Hye Jin Jung
doaj   +1 more source

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