Results 41 to 50 of about 1,623 (201)

The Efficacy of Hellebrigenin Against Nasopharyngeal Carcinoma Cells: The Molecular and Bioinformatic Analysis. [PDF]

J Cell Mol Med
ABSTRACT Nasopharyngeal carcinoma (NPC) is a unique cancer type originating from the nasopharynx. To investigate novel strategies for improving prognosis and reducing the adverse effects of current treatments, this study examined the efficacy of hellebrigenin.
Ho HY, Chen MK, Tsai YJ, Lin CC, Lo YS, Chuang YC, Hsieh MJ.   +6 more
europepmc   +2 more sources

Bioinspired Synthesis of Twin abeo‐Steroids Bufogargarizins A and B via a Divergent Intramolecular Aldol Addition Reaction

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
Twin natural products. This manuscript describes a concise biomimetic synthesis of twin abeo‐steroids bufogargarizins A and B with an unusual [7.5.6.5] and [5.7.6.5] skeletons in 19 steps (LLS). The described synthetic approach features the application of a bioinspired regiodivergent intramolecular aldol addition reaction and a selective singlet oxygen‐
Zoey J. Surma, Volodymyr Hiiuk, Eugene Zviagin, Yaxin Ouyang, Alex Chacko, Fengrui Qu, Paul M. Zimmerman, Pavel Nagorny   +7 more
wiley   +2 more sources

Bufalin-Induced Epithelial-to-Mesenchymal Transition in Kidney Epithelial Cells. [PDF]

Cell Biol Int
ABSTRACT The kidney plays a central role in fluid, electrolyte, and blood pressure regulation, processes tightly coupled to Na⁺/K⁺‐ATPase activity. Beyond its canonical transport function, Na⁺/K⁺‐ATPase also acts as a signaling receptor for cardiotonic steroids (CTSs) such as bufalin, which have been implicated in fibrosis and epithelial‐to‐mesenchymal
Barros GMO, Bagri KM, Mermelstein C, Quintas LEM.   +3 more
europepmc   +2 more sources

Chemical defense of toad tadpoles under risk by four predator species

Ecology and Evolution, 2019
Many organisms use inducible defenses as protection against predators. In animals, inducible defenses may manifest as changes in behavior, morphology, physiology, or life history, and prey species can adjust their defensive responses based on the ...
Bálint Üveges, Márk Szederkényi, Katharina Mahr, Ágnes M. Móricz, Dániel Krüzselyi, Veronika Bókony, Herbert Hoi, Attila Hettyey   +7 more
doaj   +1 more source

Rhinovirus inhibition by bufadienolides.

Chemical and Pharmaceutical Bulletin, 1988
An evaluation of thirty-four bufadienolides and two related cardenolides against a series of rhinoviruses in vitro has been completed. Most of the bufadienolides were found to display some inhibitory activity. Scillarenin and 3-O-[N-(tert-butoxycarbonyl)hydrazido]succinylbufalin were found to be the most active with chemotherapeutic indices of 32 and ...
KAMANO, YOSHIAKI, SATOH, NORIO, NAKAYOSHI, HIROSHI, PETTIT, GEORGE R., SMITH, CECIL R.   +4 more
openaire   +3 more sources

Systematic screening and characterization of novel bufadienolides from toad skin using ultra-performance liquid chromatography/electrospray ionization quadrupole time-of-flight mass spectrometry

, 2010
During the discovery process of novel compounds, it is of significant importance to differentiate novel from known compounds in crude extracts before starting the time-consuming process of purification.
Xue, Xingya, Xiao, Yuansheng, Liang, Xinmiao, 梁鑫淼, Zhang, Xiuli, Liu, Yanfang, 张秀莉   +6 more
core   +1 more source

Assessment of neuropharmacological potential of low molecular weight components extracted from Rhinella schneideri toad poison

Journal of Venomous Animals and Toxins including Tropical Diseases, 2019
Background: Studies on toad poison are relevant since they are considered a good source of toxins that act on different biological systems. Among the molecules found in the toad poison, it can be highlighted the cardiotonic heterosides, which have a ...
Mateus Amaral Baldo, Alexandra Olimpio Siqueira Cunha, Lívea Dornela Godoy, José Luiz Liberato, Juliana Sakamoto Yoneda, Elisa Correa Fornari-Baldo, Pietro Ciancaglini, Wagner Ferreira dos Santos, Eliane Candiani Arantes   +8 more
doaj   +1 more source

Antimicrobial Secretions of Toads (Anura, Bufonidae): Bioactive Extracts and Isolated Compounds against Human Pathogens

Antibiotics, 2020
Species of the family Bufonidae, better known as true toads, are widespread and produce bioactive substances in the secretions obtained from specialized skin macroglands.
Candelario Rodriguez, Roberto Ibáñez, Louise A. Rollins-Smith, Marcelino Gutiérrez, Armando A. Durant-Archibold   +4 more
doaj   +1 more source

The chemical structure of nine bufadienolides.

, 2015
The chemical structure of nine bufadienolides.
Honglan Wang (107974), Guodi Lu (735433), Qinan Wu (427609), Jing Zhou (168494), Jinao Duan (82991), Junfeng Zhang (13013), Hongyue Ma (279202)   +6 more
core   +1 more source

The Development of Toad Toxins as Potential Therapeutic Agents

Toxins, 2018
Toxins from toads have long been known to contain rich chemicals with great pharmaceutical potential. Recent studies have shown more than 100 such chemical components, including peptides, steroids, indole alkaloids, bufogargarizanines, organic acids, and
Ji Qi, Abu Hasanat Md Zulfiker, Chun Li, David Good, Ming Q. Wei   +4 more
doaj   +1 more source