Results 31 to 40 of about 1,623 (201)

An integrated strategy for comprehensive characterization of metabolites and metabolic profiles of bufadienolides from Venenum Bufonis in rats

Journal of Pharmaceutical Analysis, 2022
Comprehensive characterization of metabolites and metabolic profiles in plasma has considerable significance in determining the efficacy and safety of traditional Chinese medicine (TCM) in vivo.
Wen-Long Wei, Hao-Jv Li, Wen-Zhi Yang, Hua Qu, Zhen-Wei Li, Chang-Liang Yao, Jin-Jun Hou, Wan-Ying Wu, De-An Guo   +8 more
doaj   +1 more source

Bufadienolides from the Skin Secretions of the Neotropical Toad Rhinella alata (Anura: Bufonidae): Antiprotozoal Activity against Trypanosoma cruzi

Molecules, 2021
Toads in the family Bufonidae contain bufadienolides in their venom, which are characterized by their chemical diversity and high pharmacological potential.
Candelario Rodriguez, Roberto Ibáñez, Luis Mojica, Michelle Ng, Carmenza Spadafora, Armando A. Durant-Archibold, Marcelino Gutiérrez   +6 more
doaj   +1 more source

Bufadienolides in in vitro derived Drimia robusta plants [PDF]

, 1999
The bufadienolide content of plant material derived from tissue culture of Drimia robusta Bak was determined by spectrophotometry Bufadienolides were present in callus, and in three-, six- and ten-month-old ex vitro plants.
Luyt, R.P., Luyt, RP, van Staden, J., Jäsger, A.K., van Staden, J, Jäger, Anna   +5 more
core   +1 more source

Convergent Total Synthesis of 16β‐Hydroxylpseudobufarenogin

Angewandte Chemie, Volume 138, Issue 23, 1 June 2026.
We present a novel convergent strategy that integrates Pd/Ag‐promoted Suzuki–Miyaura coupling with Ir‐catalyzed radical‐relay cyclization, enabling the first total synthesis of 16β‐hydroxylpseudobufarenogin. This approach is broadly applicable to the total synthesis of various oxygenated bufadienolides by simply modifying the fragment structures ...
Wataru Shigematsu, Yo Matsumoto, Koichi Hagiwara, Masayuki Inoue   +3 more
wiley   +2 more sources

Bersaldegenin-1,3,5-orthoacetate induces caspase-independent cell death, DNA damage and cell cycle arrest in human cervical cancer HeLa cells

Pharmaceutical Biology, 2021
Context Bufadienolide compounds occur in many plants and animal species and have strong cardiac and anti-inflammatory properties. The compounds have been recently investigated for cytotoxic and antitumor activity.
Justyna Stefanowicz-Hajduk, Magdalena Gucwa, Barbara Moniuszko-Szajwaj, Anna Stochmal, Anna Kawiak, J. Renata Ochocka   +5 more
doaj   +1 more source

Chemistry and the Potential Antiviral, Anticancer, and Anti-Inflammatory Activities of Cardiotonic Steroids Derived from Toads

Molecules, 2022
Cardiotonic steroids (CTS) were first documented by ancient Egyptians more than 3000 years ago. Cardiotonic steroids are a group of steroid hormones that circulate in the blood of amphibians and toads and can also be extracted from natural products such ...
Hesham R. El-Seedi, Nermeen Yosri, Bishoy El-Aarag, Shaymaa H. Mahmoud, Ahmed Zayed, Ming Du, Aamer Saeed, Syed G. Musharraf, Islam M. El-Garawani, Mohamed R. Habib, Haroon Elrasheid Tahir, Momtaz M. Hegab, Xiaobo Zou, Zhiming Guo, Thomas Efferth, Shaden A. M. Khalifa   +15 more
doaj   +1 more source

High Resolution Mass Profile of Bufadienolides and Peptides Combing with Anti-Tumor Cell Screening and Multivariate Analysis for the Quality Evaluation of Bufonis Venenum

Molecules, 2019
In order to evaluate the quality of Bufonis Venenum commercial herbs, a three-step qualitative and quantitative research study was performed. Firstly, we tried to identify small molecules and peptides in Bufonis Venenum using pre-fractionation ...
Rongrong He, Hongyue Ma, Jing Zhou, Zhenhua Zhu, Xiang Lv, Quan Li, Hengbin Wang, Yanqing Yan, Niancui Luo, Liuqing Di, Qinan Wu, Jinao Duan   +11 more
doaj   +1 more source

Circular Dichroism of Bufadienolides [PDF]

, 1985
With the help of PMO theory a non-empirical sector rule has been derived for the n ~ 1t5* band CD (around 260 nm) of the pentadienolide chromophore of steroidal bufadienolides.
Feliksa Snatzke, Kamano, Yoshiaki, Margaret L. Niven, Green, Brian, Snatzke, Gunther, Pettit, George R., Yoshiaki Kamano, Gunther Snatzke, Niven, Margaret L., Brian Green, Snatzke, Feliksa, George R. Pettit   +11 more
core   +1 more source

Biological activities of leaf extracts from selected Kalanchoe species and their relationship with bufadienolides content

Pharmaceutical Biology, 2020
Context Kalanchoe species (Crassulaceae) are widely used in traditional medicine as remedies in infectious diseases and cancer treatment. Objective Cytotoxic and antimicrobial activities of Kalanchoe daigremontiana Raym.-Hamet & H. Perrier, K.
Justyna Stefanowicz-Hajduk, Anna Hering, Magdalena Gucwa, Rafał Hałasa, Agata Soluch, Mariusz Kowalczyk, Anna Stochmal, Renata Ochocka   +7 more
doaj   +1 more source

Comparative MS- and NMR-Based Metabolome Mapping of Egyptian Red and White Squill Bulbs F. Liliaceae and in Relation to Their Cytotoxic Effect

Plants, 2023
Urginea maritima L. (squill) species is widely spread at the Mediterranean region as two main varieties, i.e., white squill (WS) and red squill (RS), that are recognized for several health potentials.
Omar M. Khattab, Dina M. El-Kersh, Shaden A. M. Khalifa, Nermeen Yosri, Hesham R. El-Seedi, Mohamed A. Farag   +5 more
doaj   +1 more source