Evolutionary insights into Na<sup>+</sup>/K<sup>+</sup>-ATPase-mediated toxin resistance in the Crested Serpent-eagle preying on introduced cane toads in Okinawa, Japan. [PDF]
BMC Ecol EvolTobe A +4 more
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Multiplexed LC-MS analysis reveals novel insights into grapevine defense mechanisms by expanding metabolome coverage. [PDF]
MetabolomicsVásquez-Ocmín PG +7 more
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Concurrent Analysis of Antioxidant and Pro-Oxidant Activities in Compounds from Plant Cell Cultures. [PDF]
BioTech (Basel)Blažková M +5 more
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Antiangiogenic Potential of Beneficial Sterols from Parotoid Gland Secretion of Indian Common Toads (<i>Duttaphrynus melanostictus</i>) in the Coastal Region of the Indian Subcontinent: An <i>In Vivo</i> to <i>In Silico</i> Approach. [PDF]
ACS OmegaMaji S +3 more
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Preparation and evaluation of lyophilized liposome-encapsulated bufadienolides
Drug Development and Industrial Pharmacy, 2009The objective of this study was to prepare bufadienolides-loaded liposome (BU-lipo).The BU-lipo was prepared by a thin-film hydration method involving sonication and lyophilization procedures. The lyophilized BU-lipo was characterized with regard to the appearance and particle size by scanning electron microscopy, transmission electron microscopy, and ...
Fang Li
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Bufadienolides from Urginea maritima from Egypt
Phytochemistry, 1996Forty-one bufadienolides were isolated from the bulbs of Urginea maritima agg. from Egypt; 26 of them are new natural compounds. Structure elucidation was performed by comparison with authentic substances or by means of 1H, 13C NMR and FAB mass spectroscopy.
Wolfgang Robien +2 more
exaly +3 more sources
Journal of Pharmaceutical and Biomedical Analysis, 2014 As a kind of promising anticancer compounds, the preparation of bufadienolides is a hot study spot. However, due to the complexity of biological sample, the purification of bufadienolides from a crude sample (toad skin) is a tough work. In this paper, we
Wei Lai, Zhen Long, Xiuli Zhang
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Cytotoxicity-guided fractionation of the MeOH extract of Helleborus lividus Aiton ex Curtis (Ranunculaceae) resulted in the isolation of five undescribed bufadienolide glycosides and two undescribed bufadienolides, along with three known compounds. Their structures were determined by detailed spectroscopic analysis and hydrolysis studies.
Iguchi, Tomoki +4 more
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Bufadienolides and their antitumor activity
Natural Product Reports, 2011Since 1998, a great number of bufadienolides have been reported from plants, animals and plant cell suspensions, as well as from fungi and bacteria cultures. This review summarizes both new bufadienolides and those obtained from new sources, together with data regarding the antitumor activity of bufadienolide derivatives.
Gao, Huimin +3 more
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A novel bufadienolide synthesis
Steroids, 1974Abstract A simple two-step synthesis of bufadienolides is reported. It consists in the addition of the dimethyl acetal of chloroketene to a steroidal 20-methylene 21-aldehyde and in the treatment of the resulting 2,2-dimethoxy 3-chloro 2,3-dihydropyran with sodium methoxide in dimethylsulfoxide.
A, Bélanger +3 more
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