Results 151 to 160 of about 1,623 (201)

Bufadienolides with cytotoxic activity from the skins of Bufo bufo gargarizans

Fìtoterapìâ, 2015
Twelve new bufadienolides (1-12), along with fourteen known analogues (13-26) were isolated from the skins of Bufo bufo gargarizans Cantor. Their chemical structures were elucidated on the basis of NMR, HRESIMS and X-ray diffraction analysis.
Lei Wang, Ren-Wang Jiang, Hai-Yan Tian   +2 more
exaly   +2 more sources

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Biosynthesis of bufadienolides—3β-hydroxycholanates as precursors in Bufo marinus bufadienolides synthesis

Biochemical Pharmacology, 1969
Abstract The biosynthesis of bufadienolides in toads ( Bufo marinus ) was investigated by measuring the radioactivity of resibufogenin, bufalin, marinobufagin and telocinobufagin in the venom following injection of some possible precursors labeled with 14 C or tritium.
C, Chen, M V, Osuch
openaire   +2 more sources

ChemInform Abstract: BUFADIENOLIDE 20. MITT. 14BETA‐CHLOR‐BUFADIENOLIDE

Chemischer Informationsdienst, 1973
AbstractDie Epoxide (Ia) und (Ib) reagieren mit Chlorwasserstoff in Chloroform zu den Chlorhydrinen (IIa) und (IIb).
Y. KAMANO, G. R. PETTIT
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Structure of the bufadienolide bufotalin

Journal of the Chemical Society D: Chemical Communications, 1970
Mass spectral and 1H n.m.r. evidence, coupled with degradation of bufotalin to 3β-acetoxybufotalien (II), in turn prepared by total synthesis, provide unequivocal support for the assignment of structure (I) to bufotalin.
George R. Pettit, Peter Brown, Fred Bruschweiler, Leonard E. Houghton   +3 more
openaire   +1 more source

Unified Total Synthesis of Five Bufadienolides

Organic Letters, 2020
We report a unified total synthesis of five bufadienolides: bufalin (1), bufogenin B (2), bufotalin (3), vulgarobufotoxin (4), and 3-(N-succinyl argininyl) bufotalin (5). After the steroidal ABCD ring 8 was produced, the D ring was cross-coupled with a 2-pyrone moiety and stereoselectively epoxidized to generate 6.
Shinsuke Shimizu, Koichi Hagiwara, Hiroaki Itoh, Masayuki Inoue   +3 more
openaire   +2 more sources

Bufadienolides from animal and plant sources

Phytochemistry, 1998
Abstract Naturally occurring bufadienolides, which were isolated from both animal and plant sources and structurally elucidated in the period from 1967–1995, are reviewed and compiled.
Krenn, Liselotte, Kopp, Brigitte
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Antiviral Activity of Scillarenin, a Plant Bufadienolide

Japanese Journal of Microbiology, 1974
ABSTRACTAntiviral activity of scillarenin, a plant bufadienolide, and its mode of action were studied. Scillarenin selectively inhibited replication of picornaviruses, in particular, rhinovirus. At concentrations inhibiting rhinovirus replication, scillarenin had no effect on the synthesis of macromolecules in host cells.
N, Sato, T, Muro
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Biosynthesis of bufadienolides in toads. V. the origin of the cholesterol used by toad parotoid glands for biosynthesis of bufadienolides

Steroids, 1984
Sodium (1-14C)acetate and (5-3H) mevalonate were incubated with Bufo arenarum toad parotid gland and liver tissues. Both labelled compounds were incorporated into cholesterol produced by liver while the incubations with parotid gland produced no labelled cholesterol.
T A, Santa Coloma, H M, Garraffo, O P, Pignataro, E H, Charreau, E G, Gros   +4 more
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Cardenolide and bufadienolide derivatives of ajmaline

Chemistry of Natural Compounds, 1979
A description is given of the synthesis of new compounds — 3-O-(ajmalin-N(b)-ioacetyl)strophanthidin and 3-O-(ajmalin-N(b)-ioacetyl)hellebrigenin bromides — possessing antiarrhythmic and cardiotonic activity. The synthesis was performed in two stages: 1) a preparation of halogen derivatives of the cardiac aglycones by acylating them with bromoacetyl ...
I. F. Makarevich, Ya. I. Khadzhai, A. V. Nikolaeva, V. V. Pavlova   +3 more
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A Suzuki coupling approach to bufadienolides

Tetrahedron Letters, 2001
Abstract A high yielding route to bufadienolide type steroids using a novel Suzuki coupling reaction between a range of steroid vinyl triflates and 2-pyrone-5-boronate 11 is presented.
Edward C Gravett, Philip J Hilton, Keith Jones, Fernando Romero   +3 more
openaire   +1 more source