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Changing the Buffer in Buffered Lidocaine
Journal of Infusion Nursing, 2022Hospitalized patients require venous access for procedures, treatments, or therapies. The use of lidocaine for pain relief during central vascular access device (CVAD) insertion is a standard of practice. Lidocaine buffered with sodium bicarbonate has been shown to provide significantly more pain relief in the sensation of pain upon injection ...
Ann, Plohal +4 more
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Cold Spring Harbor Protocols, 2018
Biological reactions work well only within a narrow concentration range of hydrogen ions. Paradoxically, however, many of these reactions themselves generate or consume protons. Buffers are substances that undergo reversible protonation within a particular pH range and therefore maintain the concentration of hydrogen ions within acceptable limits. This
Michael R, Green, Joseph, Sambrook
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Biological reactions work well only within a narrow concentration range of hydrogen ions. Paradoxically, however, many of these reactions themselves generate or consume protons. Buffers are substances that undergo reversible protonation within a particular pH range and therefore maintain the concentration of hydrogen ions within acceptable limits. This
Michael R, Green, Joseph, Sambrook
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ChemPhysChem, 2014
AbstractThis paper proposes a new type of molecular device that is able to act as an inverse proton sponge to slowly decrease the pH inside a reaction vessel. This makes the automatic monitoring of the concentration of pH‐sensitive systems possible. The device is a composite formed of an alkyl chloride, which kinetically produces acidity, and a buffer ...
Alibrandi, Giuseppe +3 more
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AbstractThis paper proposes a new type of molecular device that is able to act as an inverse proton sponge to slowly decrease the pH inside a reaction vessel. This makes the automatic monitoring of the concentration of pH‐sensitive systems possible. The device is a composite formed of an alkyl chloride, which kinetically produces acidity, and a buffer ...
Alibrandi, Giuseppe +3 more
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Buffer capacity of biologics—from buffer salts to buffering by antibodies
Biotechnology Progress, 2013Controlling pH is essential for a variety of biopharmaceutical process steps. The chemical stability of biologics such as monoclonal antibodies is pH‐dependent and slightly acidic conditions are favorable for stability in a number of cases. Since control of pH is widely provided by added buffer salts, the current study summarizes the buffer ...
Anne R, Karow +2 more
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Buffer Index and Buffer Capacity for a Simple Buffer Solution
Journal of Chemical Education, 1997Many papers that present the buffering effect of the simple buffer solution consider the notion of buffer index and buffer capacity as being equivalent. Moreover, IUPAC defies them as the same thing. According to the definition of the authors who have introduced these two units, the paper shows that there is a large difference between them.
Veronica Chiriac, Gabriel Balea
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Respiration Physiology, 1978
In the quantification of buffering the distinct roles of bicarbonate and of other buffers must be taken into account. The determination of the total non-bicarbonate buffer value, betaa, in intact tissues is complicated by active pH regulation and by heterogeneity of cytoplasm with respect to betaa, while heterogeneity with respect to pH in vivo could ...
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In the quantification of buffering the distinct roles of bicarbonate and of other buffers must be taken into account. The determination of the total non-bicarbonate buffer value, betaa, in intact tissues is complicated by active pH regulation and by heterogeneity of cytoplasm with respect to betaa, while heterogeneity with respect to pH in vivo could ...
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2018
Each biological system possesses a widely unrecognized buffer system to maintain acid-base balance to a specific pH. Our lives are dependent on the functioning of buffer systems. A buffer system is a solution that resists a change in pH when acids or bases are added. The skin possesses a fairly high buffer capacity, which is determined by the amount of
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Each biological system possesses a widely unrecognized buffer system to maintain acid-base balance to a specific pH. Our lives are dependent on the functioning of buffer systems. A buffer system is a solution that resists a change in pH when acids or bases are added. The skin possesses a fairly high buffer capacity, which is determined by the amount of
openaire +2 more sources