Results 101 to 110 of about 663,058 (303)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Potential of water sediments in construction materials: Current approaches and critical consideration of future challenges

Heliyon
Human activities result in sediment accumulation, so the reservoirs gradually lose their functionality, impacting their ability to manage large flood inflows, supply water, and generate hydroelectric power.
Jan Fořt, Ayodele Afolayan, Václav Kočí, Lenka Scheinherrová, Jiří Jan, Jakub Borovec, Robert Černý   +6 more
doaj   +1 more source

Construction and Application of Indoor Video Surveillance System Based on Human Activity Recognition

MATEC Web of Conferences, 2018
With the growth of building monitoring network, increasing human resource and funds have been invested into building monitoring system. Computer vision technology has been widely used in image recognition recently, and this technology has also been ...
Wang Yuchen, Wang Mantao, Tan Zhouyu, Zhang Jie, Li Zhiyong, Mu Jiong, Zhou Zhihao, Luo Lixing   +7 more
doaj   +1 more source

Soft self-assembled nanoparticles with temperature-dependent properties

, 2015
The fabrication of versatile building blocks that are reliably self-assemble into desired ordered and disordered phases is amongst the hottest topics in contemporary material science.
Capone, Barbara, Likos, Christos N., Rovigatti, Lorenzo   +2 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Beyond Functionality: Building Value To Essential Oils Products at Indonesia Digital Market Field

Indonesian Journal of Business and Entrepreneurship
Background: This study investigates the evolving online marketing skills in the digital marketplace, focusing on essential oil products. These products often face market uncertainty regarding product attribute value.
Zainur Romli
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Experimental Study on Seismic Performance Evaluation of a Multi-Story Steel Building Model with Rolling-Type Seismic Base Isolation

Buildings
Critical structures such as hospitals, high-precision manufacturing facilities, telecommunications centers, and fire stations, especially, need to maintain their functionality even during severe earthquakes.
Hakan Öztürk, Erkan Çelebi, Cemalettin Kaya   +2 more
doaj   +1 more source