Results 71 to 80 of about 80,651 (245)

Innovative Approach to the Configuration of Smart Buildings

open access: yesIn_Bo, 2018
In the construction sector, a strong push for innovation is due to the demand for high quality standards of living that can be related to safety, accessibility, usability, energy efficiency, as well as sustainability in terms of construction and ...
Rossana Paparella, Mauro Caini
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Building information modelling and project information management framework for construction projects

open access: yesJournal of Civil Engineering and Management, 2019
The study aims to develop an effective BIM-project information management framework (BIM-PIMF) and associated assessment model for construction projects with a view to enhancing the functional management of project information.
Timothy O. Olawumi, Daniel W. M. Chan
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Towards the cognitive building: information modeling for the energy audit

open access: yesTema, 2018
The new paradigm of smart building requires the accomplishment of occupants needs through the analysis of data gathered within the building, which switches from activities host to provider of customized services for occupants. The digitalization supports
Giuseppe Martino Di Giuda   +5 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Performance Predictions of Dry and Wet Vapors Ejectors Over Entire Operational Range

open access: yesEnergies, 2017
If a traditional ideal-gas ejector model is used to evaluate the performance of a wet vapor ejector, large deviations from the experimental results will be unavoidable.
Fenglei Li   +4 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

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