Results 81 to 90 of about 19,365,633 (281)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Critical Success Factors for Building Information Modelling Implementation
Construction Economics and Building, 2018 Adoption of Building Information Modelling (BIM) in the global construction industry is fast growing. This paper expounds the Critical Success Factors (CSFs) for BIM implementation and explore their ranking and underlying relationships.
Ganiyu Amuda-Yusuf
doaj +1 more source
Building information modelling: protocols for collaborative design processes [PDF]
, 2014 Numerous frameworks and protocols are being developed to facilitate BIM understanding and implementation. A BIM framework is a structured theoretical construct that can assist in organizing BIM domains of knowledge and facilitate the creation of new ...
Kelly, Graham +5 more
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Analysis Framework for the Interaction Between Lean Construction and Building Information Modelling [PDF]
Building with Building Information Modelling (BIM) changes design and production processes. But can BIM be used to support process changes designed according to lean production and lean construction principles? To begin to answer this question we provide
Owen, Robert +3 more
core +3 more sources
Project Leadership and SocietyThe construction industry in developing countries faces significant challenges, including limited resources, infrastructure constraints, and varying levels of technological readiness, which hinder the adoption of Building Information Modelling.
Sonam Rinchen +2 more
doaj +1 more source
Innovative Approach to the Configuration of Smart Buildings
In_Bo, 2018 In the construction sector, a strong push for innovation is due to the demand for high quality standards of living that can be related to safety, accessibility, usability, energy efficiency, as well as sustainability in terms of construction and ...
Rossana Paparella, Mauro Caini
doaj +1 more source
Building Information Modelling design ecologies - a new model? [PDF]
, 2012 This paper considers the barriers to BIM adoption and demonstrates they are symptoms of existing problems in the Architecture, Engineering, Construction, and Operations (AECO) industry. When current external pressures are considered, a varied and complex
Jones, Derek, Dewberry, Emma
core +2 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source