Results 91 to 100 of about 100,537 (296)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Making an engine: performativities of building information standards

, 2017
Digitization of buildings requires the systematic handling of a variety and volumes of data. It is a common vision to aim for coordinated homogenization of data structures, enabled by the classification of information.
Christian Koch, Sjouke Beemsterboer, Beemsterboer, Sjouke,, Koch, Christian,, Koch, Christian, Beemsterboer, Sjouke   +5 more
core   +1 more source

Critical Success Factors for Building Information Modelling Implementation

Construction Economics and Building, 2018
Adoption of Building Information Modelling (BIM) in the global construction industry is fast growing. This paper expounds the Critical Success Factors (CSFs) for BIM implementation and explore their ranking and underlying relationships.
Ganiyu Amuda-Yusuf
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Building information modeling

, 2019
N ...
Herbert W. Stanford, Adam F. Spach
openaire   +3 more sources

Innovative Approach to the Configuration of Smart Buildings

In_Bo, 2018
In the construction sector, a strong push for innovation is due to the demand for high quality standards of living that can be related to safety, accessibility, usability, energy efficiency, as well as sustainability in terms of construction and ...
Rossana Paparella, Mauro Caini
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Parametric and generative methods with building information modelling: Connecting BIM with explorative design modelling

, 2012
The design of architecture, in practice, entails the collaboration of many disciplines each with their own set of tools and representations. Building Information Models aim to support interoperability between these disciplines.
A. Burden, Fernando, Ruwan, Burden, Alan, R. Fernando, Drogemuller, Robin, R. Drogemuller   +5 more
core  

Driving digital transformation in construction: Strategic insights into building information modelling adoption in developing countries

Project Leadership and Society
The construction industry in developing countries faces significant challenges, including limited resources, infrastructure constraints, and varying levels of technological readiness, which hinder the adoption of Building Information Modelling.
Sonam Rinchen, Saeed Banihashemi, Suhair Alkilani   +2 more
doaj   +1 more source

Building information modelling and project information management framework for construction projects

Journal of Civil Engineering and Management, 2019
The study aims to develop an effective BIM-project information management framework (BIM-PIMF) and associated assessment model for construction projects with a view to enhancing the functional management of project information.
Timothy O. Olawumi, Daniel W. M. Chan
doaj   +1 more source