Results 71 to 80 of about 3,800,881 (287)

Development of sustainable material for hybrid wall system to improve indoor thermal performance [PDF]

, 2017
Thermal performance of building envelope has been of great importance in determining the indoor thermal environment mainly due to the impact of existing global warming issues.
Narendra raut, Ashwin
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

High-Performance Buildings

Innovations: Technology, Governance, Globalization, 2009
enhancing economic growth, competitiveness, productivity, and quality of life. The construction industry in the United States contributes more than one trillion dollars to the yearly gross domestic product , but based on government statistics like those shown in Figure 1, it continues to stagnate or even lose productivity, unlike most other large-scale
openaire   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Adaptive Thermal Comfort Assessment in Residential Buildings Under Current and Future Mediterranean Climate Scenarios

Buildings
This article presents a comparative evaluation of three established thermal comfort models (ISSO 74, ASHRAE 55, and EN 16798-1) in the context of residential buildings in Algiers, under current and projected Mediterranean climate conditions. By combining
Asmaa Tellache, Youcef Lazri, Abdelkader Laafer, Shady Attia   +3 more
doaj   +1 more source

Improving energy modeling of large building stock through the development of archetype buildings [PDF]

, 2011
12th Conference of International Building Performance Simulation ...
Ballarini, Ilaria, Corgnati, Stefano Paolo, Corrado, Vincenzo, Tala', Novella   +3 more
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Seismic Risk Analysis of Government Buildings in the City of Tembilahan using FEMA P-58

Rekayasa Sipil
Research in estimating losses and harm experienced by structures in the high seismic zone had been conducted in previous studies. Yet there is limited study carried out in low-moderate seismic areas.
Rofriantona, Ridwan, Zulfikar Djauhari
doaj   +1 more source

In-use Energy Performance Study Of Automated Smart Homes

Journal of Sustainable Design and Applied Research in Innovative Engineering of the Built Environment, 2019
Domestic energy demand has been high on the carbon reduction agenda for some time. Today new homes are being designed following the “fabric first” principle which is reducing heat demand, but it is shifting the design challenge to ventilation.
J. MIles, K. A. Kelly, P. Sassi
doaj   +1 more source