Results 61 to 70 of about 851,768 (283)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Design of farm winery façades for the optimisation of indoor natural lighting: a case study

Journal of Agricultural Engineering, 2013
This paper deals with the theme of daylighting performances of rural buildings, within a broader research context aimed at establishing design criteria for farm wineries. The objective is to benchmark the performances of different window systems in order
Daniele Torreggiani, Valentina Corzani, Stefano Benni, Patrizia Tassinari   +3 more
doaj   +1 more source

Building Simulation Applications BSA 2013 - Proceedings of 1st IBPSA Italy conference [PDF]

, 2013
Building Simulation application 2013 was the first IBPSA Italy regional conference on building performance simulation. The two-day event focused on three main subjects: simulation of building performance, actual perspectives in building physics and ...
Baratieri, M., Corrado, Vincenzo, Gasparella, A., Patuzzi, F.   +3 more
core  

History and development of validation with the ESP-r simulation program [PDF]

, 2008
It is well recognised that validation of dynamic building simulation programs is a long-term complex task. There have been many large national and international efforts that have led to a well-established validation methodology comprising analytical ...
Ben-Nakhi, Bloomfield, G. Kokogiannakis, Haddad, I.A. Macdonald, P.A. Strachan, Strachan   +6 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Building performance simulation for sensemaking in architectural pedagogy

Buildings & Cities
During sensemaking one constructs meaning from one’s chaotic surrounding information; cues are extracted and attended to such that action is possible. Within architecture, making sense of quantitative information (e.g.
Martha Bohm
doaj   +1 more source

PEDRERA. Positive Energy District Renovation Model for Large Scale Actions

Energies, 2021
In this paper, we provide a view of the ongoing PEDRERA project, whose main scope is to design a district simulation model able to set and analyze a reliable prediction of potential business scenarios on large scale retrofitting actions, and to evaluate ...
Paolo Civiero, Jordi Pascual, Joaquim Arcas Abella, Ander Bilbao Figuero, Jaume Salom   +4 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Building Performance Analysis and Simulation: We’ve Come a Long Way

Buildings, 2014
Back in 1981, when I started doing building energy performance simulation for pre-design and energy efficiency retrofit work, building simulation was in its infancy. [...]
V. Ismet Ugursal
doaj   +1 more source