Results 121 to 130 of about 811,371 (313)
ITNOWAbstract At the forefront of two of the UK's major tech events, BCS President Daljit Rehal FBCS has been championing innovation and professionalism as the cornerstones of digital transformation and responsible AI adoption. Claire Penketh MBCS reports.
openaire +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Construction of the BA building, 1974
, 1974 16mm black and white footage from June 1974 showing the construction of the new Business and General Studies (BA) building. Film digitised by Dennis W. Nicholson (Audio Visual Production Manager), Swinburne Dept.
Swinburne College of Technology
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
, 2016 Images of the George Building taken by a camera drone in December ...
Swinburne University of Technology
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Time lapse of constructing The George building
, 2011 Time lapse video of construction at 34 Wakefield St (The George building), Hawthorn campus. Part 1: 27 May 2009 to 20 Feb 2010.
Information Technology Services
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The technical Issues associated with Algae Building Technology DOI (10.1108/IJBPA-02-2020-0012)
, 2020 As the impacts of climate change become more evident, the need to adopt new ways of constructing buildings becomes more urgent. The earth has experienced hotter climates globally for the last 70 years (NASA 2019) and this has resulted in unprecedented ...
Wilkinson, S, Ralph, P, Biloria, N
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