Results 81 to 90 of about 7,466,337 (286)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Causal effects of built environment characteristics on travel behaviour: A longitudinal approach [PDF]

, 2016
The influence of the built environment on travel behaviour and the role of intervening variables such as socio-demographics and travel-related attitudes have long been debated in the literature.
Kees Maat, van de Coevering, P.P. (author), Maat, Kees, van Wee, G.P. (author), Maat, C. (author), Maat, K., van de Coevering, PP, Kroesen, M, Paul van de Coevering, Maarten Kroesen, van Wee, B, Wee, Bert van, van de Coevering, P.P., Maat, C., Kroesen, M., Bert van Wee, Kroesen, Maarten, van Wee, G.P., Coevering, Paul van de, Kroesen, M. (author)   +19 more
core   +2 more sources

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Associate Editor, Frontiers in Built Environment, section Earthquake Engineering

, 2023
https://www.frontiersin.org/journals/built-environment/sections/earthquake-engineering ...
Alessandro Zona
core  

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Three-Dimensional Multitemporal Game Engine Visualizations for Watershed Analysis, Lighting Simulation, and Change Detection in Built Environments

ISPRS International Journal of Geo-Information
This study explores the reuse of high-resolution 3D spatial datasets for multiple urban analyses within a game engine environment, aligning with circular economy principles in sustainable urban planning. The work is situated in two residential test areas
Heikki Kauhanen, Toni Rantanen, Petri Rönnholm, Osama Bin Shafaat, Kaisa Jaalama, Arttu Julin, Matti Vaaja   +6 more
doaj   +1 more source

Associate Editor, Frontiers in Built Environment, section Earthquake Engineering

, 2022
https://www.frontiersin.org/journals/built-environment/sections/earthquake-engineering ...
Alessandro Zona
core  

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

The role of virtual reality and 3D modelling in built environment education [PDF]

, 2007
This study builds upon previous research on the integration of Virtual Reality (VR) within the built environment curriculum and aims to investigate the role of Virtual Reality and three-dimensional (3D) computer modelling on learning and teaching in a ...
Horne, Margaret, Thompson, Emine Mine, E. Thompson, M. Horne   +3 more
core  

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source