Results 71 to 80 of about 7,466,337 (286)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
BSS401: Environmental Science and Services I / College of Built Environment [PDF]
, 2015 The subject focused on (i) Environmental Sciences: Climatic influence on living comfort and the built environment.
UiTM, College of Built Environment
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Mainstreaming women into disaster risk reduction in the built environment in Sri Lanka [PDF]
, 2015 Intense damage to women caused by natural disasters urges the necessity of incorporating a women’s perspective into DRR. Gender mainstreaming has been demonstrated as a way of bringing a gender perspective into DRR as it could translate into identifying
Amaratunga, Dilanthi +2 more
core +3 more sources
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
A method for metropolitan landscape characterization; case study Rotterdam
Spool, 2014 This paper presents a theoretical and methodological framework for a comprehensive landscape characterization, focussing on the largest and most complex urban realm: the metropolitan region.
Alexandra Tisma +3 more
doaj +5 more sources
Whole-life emissions of retrofitting a pre-1919 house in Scotland: a whole-building approach
Academia Green EnergyIntroduction: In recent years, the impacts of climate change have become more pronounced, necessitating a net-zero economy to mitigate them. Scotland has an ambitious plan to reach a zero-emission economy by 2045.
Rania Obead +2 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
The Social Zipper: Redefining the Role of Streets in Disadvantaged Housing Estates
Urban PlanningDanish postwar non‐profit housing estates reflect the rise of the welfare state by providing quality housing for all, regardless of income. Typically built on the outskirts of cities, these estates were shaped by modernist ideals of traffic separation ...
Lene Wiell Nordberg +5 more
doaj +1 more source