Results 61 to 70 of about 3,007,514 (284)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Place-Making or Place-Taking? Transformation of Danish Disadvantaged Housing Estates

Nordic Journal of Urban Studies
Several Danish social housing estates are currently being transformed according to the Parallel Society Act. This legislation has introduced what is, in a Danish context, a new approach to regeneration, involving tenure mix, evictions, and targeted ...
Marie Stender, Lene Wiell Nordberg, Rikke Skovgaard Nielsen, Mette Mechlenborg, Claus Bech-Danielsen   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Analysing the Environmental and Social Impacts of a Novel User-Based Transit Signal Priority Strategy in a Connected Vehicle Environment

Journal of Advanced Transportation
Transit signal priority (TSP) is a traffic control strategy aiming at prioritising public transit vehicles at signalised intersections. The emergence of connected vehicles (CVs) provides the opportunity to enhance TSP operation, mitigating challenges ...
Roozbeh Mohammadi, Shaghayegh Vosough, Claudio Roncoli   +2 more
doaj   +1 more source

Food Environment, Built Environment, and Women\u27s BMI: Evidence from Erie County, New York [PDF]

, 2010
The authors present the results of a neighborhood-scaled exploratory study that tests the association of the food environment and the built environment with women’s body mass index (BMI) in Erie County, New York.
Alex Brian Ticoalu, Changxing Ma, James Roemmich, Leonard Epstein, Li Yin, Pavan Yadav, Samina Raja   +6 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Geomicrobiology of the built environment [PDF]

, 2017
Microbial colonization and growth can have significant effects in the built environment, resulting in a range of effects from discolouration and staining to biodeterioration and decay.
A de los Rios, A Rosling, AA Gorbushina, AA Gorbushina, AA Gorbushina, AA Gorbushina, AG Jongmans, AJ Hoisington, AS Amend, AS Amend, B Cwalina, B Gutarowska, B Lian, BH Kim, C Gaylarde, C Gaylarde, C Gaylarde, C Moses, C Sabbioni, C Saiz-Jiminez, C Urzi, CE Turick, CS Cockell, D de la Fuente, D Hawksworth, D Nica, DB Gleeson, DB Gleeson, DB Gleeson, E Hutchens, E Joseph, EP Burford, Eric A. Franzosa, F Pinzari, F Pinzari, G Grote, G Piñar, G Ranalli, G Roeselers, GJ Dick, GK Druschel, GM Gadd, GM Gadd, GM Gadd, GM Gadd, GM Gadd, GM Gadd, GM Gadd, GM Gadd, GM Gadd, GZ Brown, H Sverdrup, H Viles, H-C Flemming, HA Viles, HL Ehrlich, IB Beech, J Aramendia, J Chase, J Chen, J Fouquier, J-D Gu, JD Ettenauer, JJ Walker, JP McIlroy de la Rosa, JS Wright, JWT Wimpenny, K Sterflinger, K Sterflinger, K Sterflinger, KH Nealson, LD Stetzenbach, M Del Monte, M Fomina, M Fomina, M Garcia-Valles, M Hoppert, M Lisci, M Miletto, M Monte, M Radeka, M Smits, MA de la Torre, MHY Leung, ML Coutinho, MM Smits, MM Smits, MRD Seaward, N Cutler, NA Cutler, NEA Carter, NN Zhdanova, R Kumar, R Mitchell, RI Adams, RI Adams, RJ Koestler, S Bonneville, S Dedesko, S Lax, S Scheerer, S Uroz, SE Favero-Longo, SE Favero-Longo, SL Brantley, SL Brantley, ST Kelley, SW Kembel, T Konya, T Rosado, T Warsheid, The MetaSUB International Consortium, TJ McMaster, U Brehm, V Jurado, W Sand, WB Lyons, WW Barker, WW Barker, X Arino, YJ Rhee   +120 more
core   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The Social Zipper: Redefining the Role of Streets in Disadvantaged Housing Estates

Urban Planning
Danish postwar non‐profit housing estates reflect the rise of the welfare state by providing quality housing for all, regardless of income. Typically built on the outskirts of cities, these estates were shaped by modernist ideals of traffic separation ...
Lene Wiell Nordberg, Rikke Borg Sundstrup, Marie Stender, Rikke Skovgaard Nielsen, Mette Mechlenborg, Claus Bech-Danielsen   +5 more
doaj   +1 more source

What are the visual communication requirements of a built environment? [PDF]

, 2006
This paper explores an aspect of the Built Environment that is part of our everyday lives, yet often goes unnoticed. It is something that is not far away from any vista. It often appears frivolous, and yet can be a matter of life or death.
Harland, RG
core   +1 more source