Results 51 to 60 of about 455,645 (247)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Product Development Lab (PD Test Lab)

Spool, 2018
The file to factory approach is investigated within the Product Development Test Lab, with the first entirely digitally produced building as a demonstrator and test lab on the campus of TU Delft.
Pieter Stoutjesdijk, Tillmann Klein, Marcel Bilow, Jos Lichtenberg, Jeroen van Veen, Nick van der Knaap   +5 more
doaj   +5 more sources

A method for metropolitan landscape characterization; case study Rotterdam

Spool, 2014
This paper presents a theoretical and methodological framework for a comprehensive landscape characterization, focussing on the largest and most complex urban realm: the metropolitan region.
Alexandra Tisma, Rene van der Velde, Steffen Nijhuis, Michiel Pouderoijen   +3 more
doaj   +5 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

An Investigation into the Effects of Risks and Risk Management of Bioenergy Projects

E3S Web of Conferences, 2018
Risk is an important component in project management and plays a key role in securing project finance in renewable energy sector. As the amount of companies making investment in renewables grow, so do the inherent risks in the different stages of the ...
Bature Aminu, Melville Lynsey, Mizanur Rahman Khondokar, Akhtar Jahangir, Aulak Poonam   +4 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Analysing the Environmental and Social Impacts of a Novel User-Based Transit Signal Priority Strategy in a Connected Vehicle Environment

Journal of Advanced Transportation
Transit signal priority (TSP) is a traffic control strategy aiming at prioritising public transit vehicles at signalised intersections. The emergence of connected vehicles (CVs) provides the opportunity to enhance TSP operation, mitigating challenges ...
Roozbeh Mohammadi, Shaghayegh Vosough, Claudio Roncoli   +2 more
doaj   +1 more source