Results 51 to 60 of about 3,007,514 (284)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

An Investigation into the Effects of Risks and Risk Management of Bioenergy Projects

E3S Web of Conferences, 2018
Risk is an important component in project management and plays a key role in securing project finance in renewable energy sector. As the amount of companies making investment in renewables grow, so do the inherent risks in the different stages of the ...
Bature Aminu, Melville Lynsey, Mizanur Rahman Khondokar, Akhtar Jahangir, Aulak Poonam   +4 more
doaj   +1 more source

Built environment and diabetes

International Journal of Diabetes in Developing Countries, 2010
Development of type 2 diabetes mellitus is influenced by built environment, which is, 'the environments that are modified by humans, including homes, schools, workplaces, highways, urban sprawls, accessibility to amenities, leisure, and pollution.' Built environment contributes to diabetes through access to physical activity and through stress, by ...
Pasala, Sudhir Kumar, Rao, Allam Appa, Sridhar, G. R.   +2 more
openaire   +3 more sources

Models and metaphors: complexity theory and through-life management in the built environment [PDF]

, 2008
Complexity thinking may have both modelling and metaphorical applications in the through-life management of the built environment. These two distinct approaches are examined and compared.
Allen P. M., Allen P. M., Arthur B. W., Arthur B. W., Baldwin A. N., Ballard G., Ballard G., Ballard G., Berry J. S., Bertelsen S., Bertelsen S., Bertelsen S., Bertelsen S., Bresnen M., Burke K., Button G., Button G., Carroll T., Carys Siemieniuch, Codd E. F., de Bono E., Dijkstra J., Dutton J. M., Ella-Mae Molloy, Gardner M., Garfinkel H., Garfinkel H., Gershenson C. H., Groak S., Guastello S. J., Handy C., Hofstede G., Hopp W. J., Ivory C., John Rooke, Kanter R. M., Koskela L., Koskela L., Kosko B., Lauri Koskela, Livingston E., Mike Kagioglou, Mittleton-Kelly E., Mohan Siriwardena, Morgan G., Murray Sinclair, Parsons T., Parsons T., Payr S., Peters T. J., Richardson K., Robertson D. A., Ryle G., Sacks H., Sacks H., Schutz A., Seese D., Shen W., Smallwood J., Stacey R. D., Steeb W.-H., Strauss A., Thomassen M. A., von Neumann J., Weber M., Wittgenstein L., Wolfram S.   +66 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Deployable structures in the built environment [PDF]

, 2015
The occurrence of natural disasters has been on the increase for the last decade. One of the most prominent incidences has been the occurrence of floods which has been experienced in developing and developed countries.
Umweni, OJ
core  

AdaptSTAR model: A climate-friendly strategy to promote built environment sustainability [PDF]

, 2013
Building adaptive reuse plays a critical role in emissions reduction and supports global climate protection. Thus, the designing of future buildings with embedded adaptive reuse potential is a useful criterion for sustainability. This paper describes the
Conejos, Sheila, Langston, Craig, Smith, Jim   +2 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The Built Environment and Physical Activity: What Is the Relationship? [PDF]

, 2007
Synthesizes research on how the built environment -- recreational resources, land use mix and connectivity, presence of sidewalks and streetlights, and community environment -- affects residents' physical activity and health across ...
Claudia H. Williams
core  

Towards building information modelling for existing structures [PDF]

, 2008
The transformation of cities from the industrial age (unsustainable) to the knowledge age (sustainable) is essentially a ‘whole life cycle’ process consisting of; planning, development, operation, reuse and renewal.
Arayici, Y
core   +2 more sources