Results 41 to 50 of about 455,645 (247)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
The LIGHTVAN: Mobile light laboratory
Spool, 2014 The 'LIGHTVAN' research aims to optimize the lighting design for healthy schools and modern senior housing and care homes with regards to the use of light as a cheap and important source of energy. A multi-functional mobile light laboratory was built
Truus Hordijk +3 more
doaj +3 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Multi-agent systems in climate-resilient land-use planning: a review
International Journal of Digital EarthWith the gradual evolution of human land-use patterns, climate and land-use change have become increasingly intertwined, requiring integrated strategies for sustainable management.
Yinuo Zhou +3 more
doaj +1 more source
Cleanliness in context: reconciling hygiene with a modern microbial perspective
Microbiome, 2017 The concept of hygiene is rooted in the relationship between cleanliness and the maintenance of good health. Since the widespread acceptance of the germ theory of disease, hygiene has become increasingly conflated with sterilization. In reviewing studies
Roo Vandegrift +7 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Wellbeing, Space and SocietyUrban green spaces (UGS) are vital for promoting public health and social well-being, yet research on their specific impact on social interaction of the elderly (SIE) remains inadequate, particularly concerning underlying mechanisms and moderating ...
Min Wang +4 more
doaj +1 more source
ISPRS International Journal of Geo-Information, 2020 Roadside vegetation can affect the performance of installed road lighting. We demonstrate a workflow in which a car-mounted measurement system is used to assess the light-obstructing effect of roadside vegetation. The mobile mapping system (MMS) includes
Mikko Maksimainen +6 more
doaj +1 more source