Results 91 to 100 of about 906,917 (283)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Unreliable M[X]/G(P1,P2)/1 feedback retrial queues with combined working vacation

Heliyon
The study examines M[X]/G(P1,P2)/1 feedback retrial queues coupled with starting failure, repair, delay to repair, working vacation, and general retrial times.
Bharathy S, Saravanarajan M.C.
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

predation-arrival-time: First release

, 2016
<p>This is the first release of code for the model described in 'Predation can select for later and more synchronous arrival times in migrating species' by Harts, Anna M., Kristensen, Nadiah P., and Kokko, Hanna.</p ...
Nadiah Kristensen
core   +1 more source

A queueing approach for the analysis of finite bulk arrival production process with two-class arrivals and customer impatience

Cogent Engineering
The present paper explains the performance of a production process of finite capacity for two classes of customers who may exhibit impatience. The arrivals can be found in terms of batches and will be picked for service in FIFO mode.
Mahendra Varma Polakonda, Naga Ramadevi Vedala, Rajyalakshmi Kottapalli, Soloveva O.V, Oleg Igorevich Rozhdestvenskiy, Ankita Joshi   +5 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

The Discrete-Time Bulk-Service Geo/Geo/1 Queue with Multiple Working Vacations

Journal of Applied Mathematics, 2013
This paper deals with a discrete-time bulk-service Geo/Geo/1 queueing system with infinite buffer space and multiple working vacations. Considering an early arrival system, as soon as the server empties the system in a regular busy period, he leaves the
Jiang Cheng, Yinghui Tang, Miaomiao Yu
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

AN OCEAN DEPTH-CORRECTION METHOD FOR REDUCING MODEL ERRORS IN TSUNAMI TRAVEL TIME: APPLICATION TO THE 2010 CHILE AND 2011 TOHOKU TSUNAMIS [PDF]

Science of Tsunami Hazards, 2015
In this paper, we attempt to reduce the discrepancies between the modeled and observed tsunami arrival times. We treat the ocean as a homogenous fluid, ignoring stratification due to compressibility and variations of temperature and salinity.
Dailin Wang
doaj