Results 81 to 90 of about 210,338 (264)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Bloch-wave interferometry of driven quasiparticles in bulk GaAs

Physical Review B
We report that the polarizations of sidebands emitted from bulk gallium arsenide (GaAs) driven by a strong terahertz (THz) laser while probed with a weak near-infrared laser can be viewed as interferograms from a Michelson-like interferometer for Bloch waves.
Seamus D. O'Hara, Joseph B. Costello, Qile Wu, Ken West, Loren Pfeiffer, Mark S. Sherwin   +5 more
openaire   +2 more sources

Optimizing Deadline-Driven Bulk Data Transfers in Overlay Networks

2009 Proceedings of 18th International Conference on Computer Communications and Networks, 2009
Deadline-driven bulk data transfers frequently occur in overlay networks running data-intensive, dis- tributed workflow applications, such as grid and cloud envi- ronments. What distinguishes such transfers from other In- ternet traffic is that overlay nodes should cooperate towards the common goal of delivering all inter-dependent data timely, rather ...
Andrei Agapi, Sebastien Soudan, Marcelo Pasin, Pascale Vicat-Blanc Primet, Thilo Kielmann   +4 more
openaire   +5 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Nano-Resolved Current-Induced Insulator-Metal Transition in the Mott Insulator Ca_{2}RuO_{4}

Physical Review X, 2019
The Mott insulator Ca_{2}RuO_{4} is the subject of much recent attention following reports of emergent nonequilibrium steady states driven by applied electric fields or currents.
Jiawei Zhang, Alexander S. McLeod, Qiang Han, Xinzhong Chen, Hans A. Bechtel, Ziheng Yao, S. N. Gilbert Corder, Thomas Ciavatti, Tiger H. Tao, Meigan Aronson, G. L. Carr, Michael C. Martin, Chanchal Sow, Shingo Yonezawa, Fumihiko Nakamura, Ichiro Terasaki, D. N. Basov, Andrew J. Millis, Yoshiteru Maeno, Mengkun Liu   +19 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Symmetry-driven bulk-edge correspondence in electron magnetofluids at finite temperature

Physical Review Research
We present a theoretical framework connecting the pseudo-Chern number in momentum space to the spectral flow index in phase space for continuous media, with specific applications to topological Langmuir-cyclotron waves (TLCWs) in magnetized plasmas at ...
Xianhao Rao, Adil Yolbarsop, Hong Li, Wandong Liu   +3 more
doaj   +1 more source