Results 11 to 20 of about 8,305 (222)

Human and Murine IFIT1 Proteins Do Not Restrict Infection of Negative-Sense RNA Viruses of the Orthomyxoviridae, Bunyaviridae, and Filoviridae Families [PDF]

Journal of Virology, 2015
ABSTRACT Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) is a host protein with reported cell-intrinsic antiviral activity against several RNA viruses. The proposed basis for the activity against negative-sense RNA viruses is the binding to exposed 5′-triphosphates (5′-ppp) on the genome of viral RNA. However,
Pinto, Amelia K, Williams, Graham D, Szretter, Kristy J, White, James P, Proença-Módena, José Luiz, Liu, Gai, Olejnik, Judith, Brien, James D, Ebihara, Hideki, Mühlberger, Elke, Amarasinghe, Gaya, Diamond, Michael S, Boon, Adrianus C.M.   +12 more
core   +9 more sources

Immunoprophylaxis of Punta Toro virus (Phlebovirus, Bunyaviridae) infection in hamsters with recombinant Eimeria profilin-like antigen [PDF]

International Immunopharmacology, 2008
Recombinant Eimeria antigen (rEA) has been shown to have potent anticancer and antiviral activity in respective mouse disease models, presumably through robust immune stimulation that occurs via TLR11, a pattern recognition receptor that recognizes profilin-like proteins expressed on apicomplexan protozoans.
Gowen, Brian B., Judge, J. W., Wong, M. H., Jung, K. H., Aylsworth, C. F., Melby, P. C., Rosenberg, B., Morrey, John D.   +7 more
openaire   +5 more sources

Prophylactic and therapeutic intervention of Punta Toro virus (Phlebovirus, Bunyaviridae) infection in hamsters with interferon alfacon-1 [PDF]

Antiviral Research, 2008
Punta Toro virus (PTV) is a member of the Bunyaviridae family, genus Phlebovirus, related to the highly pathogenic Rift Valley fever virus (RVFV). It produces a disease in hamsters that models severe Rift Valley fever (RVF) in humans. The recent outbreak of RVF in Kenya stresses the need to identify prophylactic and therapeutic measures for preventing ...
Gowen, Brian B., Wong, M. H., Jung, K. H., Blatt, L. M., Sidwell, R. W.   +4 more
openaire   +4 more sources

Spatial-Temporal Analysis of Cache Valley Virus (Bunyaviridae:Orthobunyavirus) Infection in Anopheline and Culicine Mosquitoes (Diptera: Culicidae) in the Northeastern United States, 1997–2012 [PDF]

Vector-Borne and Zoonotic Diseases, 2014
Cache Valley virus (CVV) is a mosquito-borne bunyavirus (family Bunyaviridae, genus Orthobunyavirus) that is enzootic throughout much of North and Central America. White-tailed deer (Odocoileus virginianus) have been incriminated as important reservoir and amplification hosts. CVV has been found in a diverse array of mosquito species, but the principal
Theodore G, Andreadis, Philip M, Armstrong, John F, Anderson, Andrew J, Main   +3 more
openaire   +3 more sources

First Report of Natural Infection of Peanut (Groundnut) by Impatiens Necrotic Spot Tospovirus (Family Bunyaviridae)

Plant Disease, 1999
Impatiens necrotic spot tospovirus (INSV) of the family Bunyaviridae is an important viral pathogen of ornamentals and a major constraint in the greenhouse industry (2). Evidence of natural infection of peanut (groundnut, Arachis hypogaea L.) by INSV was found in samples collected from three sites in Frio County, TX, and one site each in Mitchell and ...
S S, Pappu, M C, Black, H R, Pappu, T B, Brenneman, A K, Culbreath, J W, Todd   +5 more
openaire   +3 more sources

The Antiviral RNAi Response in Vector and Non-vector Cells against Orthobunyaviruses. [PDF]

PLoS Neglected Tropical Diseases, 2017
BackgroundVector arthropods control arbovirus replication and spread through antiviral innate immune responses including RNA interference (RNAi) pathways. Arbovirus infections have been shown to induce the exogenous small interfering RNA (siRNA) and Piwi-
Isabelle Dietrich, Xiaohong Shi, Melanie McFarlane, Mick Watson, Anne-Lie Blomström, Jessica K Skelton, Alain Kohl, Richard M Elliott, Esther Schnettler   +8 more
doaj   +7 more sources

Punta Toro virus (Bunyaviridae, Phlebovirus) infection in mice: Strain differences in pathogenesis and host interferon response

Virology, 2009
The Adames strain of Punta Toro virus (PTV-A, Bunyaviridae, Phlebovirus) causes an acute lethal disease in hamsters and mice. The Balliet strain of the virus (PTV-B) is generally considered to be avirulent. The difference in hamster susceptibility is likely due to the ability of PTV-A to suppress interferon (IFN)-beta similarly to that described for ...
Mendenhall, M., Wong, M. H., Skirpstunas, Ramona T., Morrey, John D, Gowen, Brian B.   +4 more
openaire   +4 more sources

Experimental infection of the squirrel (Sciurus vulgaris) and the muskrat (Ondatra zibethica) with Tahyna virus (California group, Bunyaviridae).

Folia parasitologica, 1987
Two squirrels aged 16 weeks and three muskrats aged 24 weeks were subcutaneously infected with a dose of 400 SMicLD50 of the extraneurally passaged "236" strain of Tahyna virus. Viremia was detected in one squirrel (48 and 96 hours post infection) and in two muskrats (24 and 48 hours p.i.).
P, Rödl, V, Bárdos, Z, Hubálek
openaire   +2 more sources

Factors affecting RIG-I-Like receptors activation - New research direction for viral hemorrhagic fevers

Frontiers in Immunology, 2022
Viral hemorrhagic fever (VHF) is a term referring to a group of life-threatening infections caused by several virus families (Arenaviridae, Bunyaviridae, Filoviridae and Flaviviridae).
Paulina Małkowska, Paulina Małkowska, Paulina Niedźwiedzka-Rystwej   +2 more
doaj   +1 more source

Oropouche virus: clinical, epidemiological, and molecular aspects of a neglected orthobunyavirus. [PDF]

, 2017
Oropouche virus (OROV) is an important cause of arboviral illness in Latin American countries, more specifically in the Amazon region of Brazil, Venezuela and Peru, as well as in other countries such as Panama.
Acrani, Gustavo Olszanski, Cardoso, Jedson Ferreira, da Rosa, Jorge Fernando Travassos, de Paula Pinheiro, Francisco, de Souza, William Marciel, Figueiredo, Mário Luiz, Nunes, Márcio Roberto Teixeira   +6 more
core   +1 more source