Production, quantification, and infection of Amazonian Phlebovirus (Bunyaviridae)
Phlebotomine vectors, sand flies of the order Diptera, are known to transmit Leishmania parasites as well as RNA viruses (arboviruses) to humans. The arbovirus, Icoaraci Phlebovirus (BeAN 24262 - ICOV), used in this study was isolated from Nectomys rodents, a mammalian species that is the same natural sylvatic reservoir of Leishmania (Leishmania ...
Carolina Rath +3 more
openaire +4 more sources
Prophylactic and therapeutic intervention of Punta Toro virus (Phlebovirus, Bunyaviridae) infection in hamsters with interferon alfacon-1 [PDF]
Punta Toro virus (PTV) is a member of the Bunyaviridae family, genus Phlebovirus, related to the highly pathogenic Rift Valley fever virus (RVFV). It produces a disease in hamsters that models severe Rift Valley fever (RVF) in humans. The recent outbreak of RVF in Kenya stresses the need to identify prophylactic and therapeutic measures for preventing ...
Gowen, Brian B. +4 more
openaire +3 more sources
Bunyaviruses and the type I interferon system [PDF]
The family Bunyaviridae contains more than 350 viruses that are distributed throughout the world. Most members of the family are transmitted by arthopods, and several cause disease in man, domesticated animals and crop plants. Despite being recognized as
Richard M. Elliott +7 more
core +1 more source
Sequence analysis of the small (s) RNA segment of viruses in the genus Orthobunyavirus [PDF]
Viruses in the genus Orthobunyavirus (family Bunyaviridae) are classified serologically into 18 serogroups. The viruses have a tripartite genome of negative sense RNA composed of large (L), medium (M) and small (S) segments.
Mohamed, Maizan
core +2 more sources
Transmission of Heartland Virus (Bunyaviridae:Phlebovirus) by Experimentally InfectedAmblyomma americanum(Acari: Ixodidae) [PDF]
Heartland virus (HRTV; Bunyaviridae: Phlebovirus) is a recently described cause of human illness in the United States. After field studies conducted in 2012 implicated Amblyomma americanum (L.) as a vector of HRTV, we initiated experiments to assess the vector competence of A. americanum.
Marvin S, Godsey +4 more
openaire +2 more sources
Activation of PKR by Bunyamwera virus is independent of the viral interferon antagonist NSs [PDF]
Double-stranded RNA (dsRNA) is a by-product of viral RNA polymerase activity, and its recognition is one mechanism by which the innate immune system is activated.
Boyd, A. +25 more
core +1 more source
Immunoprophylaxis of Punta Toro virus (Phlebovirus, Bunyaviridae) infection in hamsters with recombinant Eimeria profilin-like antigen [PDF]
Recombinant Eimeria antigen (rEA) has been shown to have potent anticancer and antiviral activity in respective mouse disease models, presumably through robust immune stimulation that occurs via TLR11, a pattern recognition receptor that recognizes profilin-like proteins expressed on apicomplexan protozoans.
Gowen, Brian B. +7 more
openaire +3 more sources
CCHFV-related viruses (Family Bunyaviridae).
CCHFV-related viruses (Family Bunyaviridae).
Greg Smith (343139) +5 more
core +1 more source
Orthobunyavirus ultrastructure and the curious tripodal glycoprotein spike [PDF]
The genus <i>Orthobunyavirus</i> within the family <i>Bunyaviridae</i> constitutes an expanding group of emerging viruses, which threaten human and animal health.
McLees, A. +42 more
core +1 more source
Uukuniemi Phlebovirus assembly and secretion leave a functional imprint on the Virion Glycome [PDF]
Uukuniemi virus (UUKV) is a model system for investigating the genus Phlebovirus of the Bunyaviridae. We report the UUKV glycome, revealing differential processing of the Gn and Gc virion glycoproteins.
Scrivens, JH +23 more
core +1 more source

