Results 21 to 30 of about 3,850 (167)

Healthcare Professionals’ Attitudes toward Rapid Whole Genome Sequencing in Pediatric Acute Care [PDF]

Children, 2022
We aimed to characterize knowledge and attitudes about rapid whole genome sequencing (rWGS) implementation of a broad constituency of healthcare professionals at hospitals participating in a statewide initiative to implement rWGS for hospitalized ...
Linda S. Franck, Andrea Scheurer-Monaghan, Caleb P. Bupp, Joseph D. Fakhoury, Thomas J. Hoffmann, Manasi Deshpandey, Madison Arenchild, David P. Dimmock   +7 more
doaj   +2 more sources

Novel machine learning technique further clarifies unrelated donor selection to optimize transplantation outcomes [PDF]

Blood Advances
: We investigated the impact of donor characteristics on outcomes in allogeneic hematopoietic cell transplantation (HCT) recipients using a novel machine learning approach, the Nonparametric Failure Time Bayesian Additive Regression Trees (NFT BART). NFT
Stephen R. Spellman, Rodney Sparapani, Martin Maiers, Bronwen E. Shaw, Purushottam Laud, Caitrin Bupp, Meilun He, Steven M. Devine, Brent R. Logan   +8 more
doaj   +2 more sources

Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis Attenuates Disparity in Outcomes Between Use of Matched or Mismatched Unrelated Donors. [PDF]

J Clin Oncol
PURPOSE Access to allogeneic hematopoietic cell transplantation (HCT) remains limited among persons of non-European ancestry if human leukocyte antigen (HLA) matching is required.
Shaffer BC, Gooptu M, DeFor TE, Maiers M, Bolaños-Meade J, Abboud R, Briggs AD, Khimani F, Modi D, Newcomb R, Shpall EJ, Bupp C, Spellman SR, Stefanski HE, Shaw BE, Auletta JJ, Devine SM, Jimenez Jimenez AM, Al Malki MM.   +18 more
europepmc   +2 more sources

The complex, dynamic SpliceOme of the small GTPase transcripts altered by technique, sex, genetics, tissue specificity, and RNA base editing [PDF]

Frontiers in Cell and Developmental Biology, 2022
The small GTPase family is well-studied in cancer and cellular physiology. With 162 annotated human genes, the family has a broad expression throughout cells of the body. Members of the family have multiple exons that require splicing.
Akansha S. Das, Akansha S. Das, Emily C. Sherry, Emily C. Sherry, Robert M. Vaughan, Marian L. Henderson, Marian L. Henderson, Jacob Zieba, Jacob Zieba, Katie L. Uhl, Olivia Koehn, Caleb P. Bupp, Caleb P. Bupp, Surender Rajasekaran, Surender Rajasekaran, Surender Rajasekaran, Xiaopeng Li, Surya B. Chhetri, Sahar Nissim, Sahar Nissim, Sahar Nissim, Carol L. Williams, Jeremy W. Prokop, Jeremy W. Prokop, Jeremy W. Prokop   +24 more
doaj   +2 more sources

Single-cell profiling of trabecular meshwork identifies mitochondrial dysfunction in a glaucoma model that is protected by vitamin B3 treatment [PDF]

eLife
Since the trabecular meshwork (TM) is central to intraocular pressure (IOP) regulation and glaucoma, a deeper understanding of its genomic landscape is needed.
Nicholas Tolman, Taibo Li, Revathi Balasubramanian, Guorong Li, Rebecca Pfeiffer, Violet Bupp-Chickering, Ruth A Kelly, Marina Simón, John Peregrin, Christa Montgomery, Bryan Jones, W Daniel Stamer, Jiang Qian, Simon WM John   +13 more
doaj   +2 more sources

The molecular architecture of severe pediatric traumatic brain injury: integrated omics reveal therapeutic pathways. [PDF]

Crit Care
Traumatic brain injury (TBI) remains a leading cause of death and long-term disability in children worldwide. Despite its impact, current clinical management is limited to supportive care, with no FDA-approved therapies to reduce mortality or mitigate ...
Hussain E, Prokop JW, Nonnemacher E, Ashrafi N, Yilmaz A, Mimi RA, Khalid A, Krinickis K, Lomeikaite V, Sanfilippo L, Maxton K, Charron J, Subrahmanya C, Goodyke A, Needs A, Woldring DR, Bupp CP, Hartog N, Gordevicius J, Graham SF, Rajasekaran S.   +20 more
europepmc   +2 more sources

Transcriptomic profiling of Schlemm’s canal cells reveals a lymphatic-biased identity and three major cell states [PDF]

eLife
Schlemm’s canal (SC) is central in intraocular pressure regulation but requires much characterization. It has distinct inner and outer walls, each composed of Schlemm’s canal endothelial cells (SECs) with different morphologies and functions.
Revathi Balasubramanian, Krishnakumar Kizhatil, Taibo Li, Nicholas Tolman, Aakriti Bhandari, Graham Clark, Violet Bupp-Chickering, Ruth A Kelly, Sally Zhou, John Peregrin, Marina Simón, Christa Montgomery, W Daniel Stamer, Jiang Qian, Simon WM John   +14 more
doaj   +2 more sources

Role of CAMK2D in neurodevelopment and associated conditions. [PDF]

Am J Hum Genet
Rigter PMF, de Konink C, Dunn MJ, Proietti Onori M, Humberson JB, Thomas M, Barnes C, Prada CE, Weaver KN, Ryan TD, Caluseriu O, Conway J, Calamaro E, Fong CT, Wuyts W, Meuwissen M, Hordijk E, Jonkers CN, Anderson L, Yuseinova B, Polonia S, Beysen D, Stark Z, Savva E, Poulton C, McKenzie F, Bhoj E, Bupp CP, Bézieau S, Mercier S, Blevins A, Wentzensen IM, Xia F, Rosenfeld JA, Hsieh TC, Krawitz PM, Elbracht M, Veenma DCM, Schulman H, Stratton MM, Küry S, van Woerden GM.   +41 more
europepmc   +3 more sources

Collection, preparation, and biobanking of clinical specimens for analysis in polyaminopathies. [PDF]

Methods Enzymol
VanSickle EA, Schultz CR, Bachmann AS, Bupp CP.   +3 more
europepmc   +2 more sources

Ich spiele, was ich sehe

Medienimpulse, 2021
Gerade angesichts unseres Schwerpunktthemas >Mediale Gewalt als Problem< stellt Karina Kaiser-Fallent erneut medienpädagogisch wertvolle Spiele vor, die als pädagogisches Material nur darauf warten, in der konkreten Unterrichtssituation verwendet zu ...
Karina Kaiser-Fallent
doaj   +1 more source