Results 21 to 30 of about 550 (102)

Single-cell profiling of trabecular meshwork identifies mitochondrial dysfunction in a glaucoma model that is protected by vitamin B3 treatment [PDF]

eLife
Since the trabecular meshwork (TM) is central to intraocular pressure (IOP) regulation and glaucoma, a deeper understanding of its genomic landscape is needed.
Nicholas Tolman, Taibo Li, Revathi Balasubramanian, Guorong Li, Rebecca Pfeiffer, Violet Bupp-Chickering, Ruth A Kelly, Marina Simón, John Peregrin, Christa Montgomery, Bryan Jones, W Daniel Stamer, Jiang Qian, Simon WM John   +13 more
doaj   +2 more sources

Opportunities for RNA sequencing in physiology: from big data to understanding homeostasis and heterogeneity [PDF]

Function
The quantity of physiological data has grown exponentially, yielding insights into mechanisms of phenotypic and disease pathways. Among the powerful tools for physiological omics is the study of RNA, where broad sequencing of RNA leads to hypothesis ...
Jeremy W. Prokop, Stephanie M. Bilinovich, Ember Tokarski, Sangeetha Vishweswaraiah, Sophie VanderWeele, Akansha S. Das, Surya B. Chhetri, Alexander Dao, Sanjana Arora, Austin Goodyke, Katie L. Buelow, Mason Westgate, Elizabeth A. VanSickle, Claudia J. Edell, Lance N. Benson, Daniel B. Campbell, Caleb P. Bupp, Amanda Holsworth, Nicholas L. Hartog, Jena M. Krueger, Marcos Cordoba, Matthew Sims, Maximiliano A. Tamae Kakazu, Angela M. Peraino, Stewart F. Graham, Tim Triche, Elora Hussain, Mara L. Leimanis-Laurens, Connie M. Krawczyk, Jennifer S. Pollock, Surender Rajasekaran   +30 more
doaj   +2 more sources

Gene Therapy for Genetic Syndromes: Understanding the Current State to Guide Future Care [PDF]

BioTech
Gene therapy holds promise as a life-changing option for individuals with genetic variants that give rise to disease. FDA-approved gene therapies for Spinal Muscular Atrophy (SMA), cerebral adrenoleukodystrophy, β-Thalassemia, hemophilia A/B, retinal ...
Marian L. Henderson, Jacob K. Zieba, Xiaopeng Li, Daniel B. Campbell, Michael R. Williams, Daniel L. Vogt, Caleb P. Bupp, Yvonne M. Edgerly, Surender Rajasekaran, Nicholas L. Hartog, Jeremy W. Prokop, Jena M. Krueger   +11 more
doaj   +2 more sources

Transcriptomic profiling of Schlemm’s canal cells reveals a lymphatic-biased identity and three major cell states [PDF]

eLife
Schlemm’s canal (SC) is central in intraocular pressure regulation but requires much characterization. It has distinct inner and outer walls, each composed of Schlemm’s canal endothelial cells (SECs) with different morphologies and functions.
Revathi Balasubramanian, Krishnakumar Kizhatil, Taibo Li, Nicholas Tolman, Aakriti Bhandari, Graham Clark, Violet Bupp-Chickering, Ruth A Kelly, Sally Zhou, John Peregrin, Marina Simón, Christa Montgomery, W Daniel Stamer, Jiang Qian, Simon WM John   +14 more
doaj   +2 more sources

Light Water: How the Nuclear Dream Dissolved, by Irvin C. Bupp and Jean-Claude Derian

Political Science Quarterly, 1979
Steven Baker
openalex   +2 more sources

Ich spiele, was ich sehe

Medienimpulse, 2021
Gerade angesichts unseres Schwerpunktthemas >Mediale Gewalt als Problem< stellt Karina Kaiser-Fallent erneut medienpädagogisch wertvolle Spiele vor, die als pädagogisches Material nur darauf warten, in der konkreten Unterrichtssituation verwendet zu ...
Karina Kaiser-Fallent
doaj   +1 more source

Zwei besonders gelungene digitale Spiele: Spiritfarer und Splitter Critters

Medienimpulse, 2021
Im Folgenden werden zwei digitale Spiele vorgestellt, die von der „BuPP – Bundesstelle für die Positivprädikatisierung von digitalen Spielen“ empfohlen wurden. Die BuPP ist eine Einrichtung des Bundeskanzleramts, Sektion Familie und Jugend.
Karina Kaiser-Fallent
doaj   +1 more source

Density Functional Theory, Molecular Docking Study, and <i>In Vitro</i> Antioxidant Activity of Cinnamic Acid Isolated From <i>Piper betle</i> Leaves. [PDF]

Biochem Res Int
Piper betle is an edible plant known for its potent antioxidant activity. Among its phenolic constituents, cinnamic acid has been identified as a key compound contributing to this bioactivity. Although cinnamic acid is a well‐known molecule, this study is the first to report its isolation from P.
Tumilaar SG, Hardianto A, Dohi H, Kurnia D.   +3 more
europepmc   +2 more sources

GPI‐anchoring disorders and the heart: Is cardiomyopathy an overlooked feature?

Clinical Genetics, Volume 104, Issue 5, Page 598-603, November 2023., 2023
Glycosylphosphatidylinositol anchoring disorders (GPI‐ADs) are complex neurodevelopmental syndromes with a high risk of premature mortality. We have shown that patients with GPI‐ADs are at risk of developing childhood‐onset cardiomyopathy; an overlooked and potentially fatal feature.
Allan Bayat, Tobias Lindau, Angel Aledo‐Serrano, Antonio Gil‐Nagel, Ivo Barić, Dorotea Bartoniček, Josipa Mateševac, Danijela Petković Ramadža, Tamara Žigman, Silvija Pušeljić, Sanja Dorner, Caleb Bupp, Seth Devries, Rikke Steensbjerre Møller   +13 more
wiley   +1 more source

Bis(chlorido)tin(IV)meso‐substituted Porphyrins‐Characterization and Solubility

European Journal of Inorganic Chemistry, Volume 26, Issue 28, October 2, 2023., 2023
Synthetic pathway of various literature known bis(chlorido)tin(IV) meso‐tetraarylporphyrins (R*=H, Me, t‐Bu) as well as novel bis(chlorido)tin(IV) meso‐tetraarylporphyrin (R*=n‐Bu) and bis(chlorido)tin(IV) meso‐tetraalkylporphyrins (R*=Me, n‐Pr, n‐Bu) and investigation of their solubility behavior in accordance to their functional group in meso ...
Doris M. Grössl, Anna‐Viktoria Hafner, Roland C. Fischer, Robert Saf, Ana Torvisco, Frank Uhlig   +5 more
wiley   +1 more source