Results 41 to 50 of about 550 (102)
Androgen-Induced Immunosuppression
Frontiers in Immunology, 2018 In addition to determining biological sex, sex hormones are known to influence health and disease via regulation of immune cell activities and modulation of target-organ susceptibility to immune-mediated damage.Melanie R. Gubbels Bupp, Trine N. Jorgensen +1 moredoaj +1 more sourceHigh-Density Blood Transcriptomics Reveals Precision Immune Signatures of SARS-CoV-2 Infection in Hospitalized Individuals
Frontiers in Immunology, 2021 The immune response to COVID-19 infection is variable. How COVID-19 influences clinical outcomes in hospitalized patients needs to be understood through readily obtainable biological materials, such as blood.Jeremy W. Prokop, Jeremy W. Prokop, Nicholas L. Hartog, Nicholas L. Hartog, Dave Chesla, Dave Chesla, William Faber, Chanise P. Love, Rachid Karam, Nelly Abualkheir, Benjamin Feldmann, Li Teng, Tamara McBride, Mara L. Leimanis, Mara L. Leimanis, B. Keith English, Amanda Holsworth, Austin Frisch, Jacob Bauss, Nathisha Kalpage, Aram Derbedrossian, Ryan M. Pinti, Nicole Hale, Joshua Mills, Alexandra Eby, Elizabeth A. VanSickle, Spencer C. Pageau, Rama Shankar, Rama Shankar, Bin Chen, Bin Chen, Joseph A. Carcillo, Dominic Sanfilippo, Dominic Sanfilippo, Rosemary Olivero, Rosemary Olivero, Caleb P. Bupp, Caleb P. Bupp, Surender Rajasekaran, Surender Rajasekaran, Surender Rajasekaran +40 moredoaj +1 more sourceOne and a half million hematopoietic stem cell transplants: continuous and differential improvement in worldwide access with the use of non-identical family donors
Haematologica, 2021
The Worldwide Network of Blood and Marrow Transplantation (WBMT) pursues the mission of promoting hematopoietic cell transplantation (HCT) for instance by evaluating activities through member societies, national registries and individual centers.Dietger Niederwieser, Helen Baldomero, Nosa Bazuaye, Caitrin Bupp, Naeem Chaudhri, Selim Corbacioglu, Alaa Elhaddad, Cristóbal Frutos, Sebastian Galeano, Nada Hamad, Amir Ali Hamidieh, Shahrukh Hashmi, Aloysius Ho, Mary M. Horowitz, Minako Iida, Gregorio Jaimovich, Amado Karduss, Yoshihisa Kodera, Nicolaus Kröger, Regis Péffault de Latour, Jong Wook Lee, Juliana Martínez-Rolón, Marcelo C. Pasquini, Jakob Passweg, Kristjan Paulson, Adriana Seber, John A. Snowden, Alok Srivastava, Jeff Szer, Daniel Weisdorf, Nina Worel, Mickey B.C. Koh, Mahmoud Aljurf, Hildegard Greinix, Yoshiko Atsuta, Wael Saber +35 moredoaj +1 more sourceThe Confluence of Sex Hormones and Aging on Immunity
Frontiers in Immunology, 2018 The immune systems of post-pubescent males and females differ significantly with profound consequences to health and disease. In many cases, sex-specific differences in the immune responses of young adults are also apparent in aged men and women ...Melanie R. Gubbels Bupp, Tanvi Potluri, Ashley L. Fink, Sabra L. Klein +3 moredoaj +1 more sourceThe Soka Gakkai Practice of Buppō and the Discourse on Religion in Japan
Religions; Volume 13; Issue 2; Pages: 167, 2022 This paper investigates the Japanese Nichiren Buddhist organization, Soka Gakkai (SG), whose members have supported the political party known as Kōmeitō, or Clean Government Party, in Japan for over half a century. SG members have often been criticized as ‘impure’ political actors, undergoing frequent public questioning of their ...openaire +1 more sourceImplementation of First‐Line Rapid Genome Sequencing for Children in Pediatric and Cardiac Intensive Care Units
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT
Substantial data supports the use of rapid exome and genome sequencing (rES/rGS) in Neonatal Intensive Care Units (NICU), but fewer studies have examined the impact of rES/rGS in other pediatric critical care units. We evaluated the impact on diagnostic yield and time to diagnosis following a single‐center hospital policy change allowing ...Alexandra C. Keefe, Abbey A. Scott, Lukas Kruidenier, Jessie Conta, Darci L. Sternen, Sarah V. Clowes Candadai, Shannon M. Stasi, Julia Parish‐Morris, Megan Sikes, Margaret P. Adam, Anita E. Beck, Jennifer C. Hayek, Ian Glass, James T. Bennett, Ghayda Mirzaa, Paul Kruszka, Britt Johnson, Kirsty McWalter, Deborah Copenheaver, Bethany Friedman, Michael Bamshad, Katrina M. Dipple, Tara L. Wenger +22 morewiley +1 more sourcePhenotype-driven chemical screening in zebrafish for compounds that inhibit collective cell migration identifies multiple pathways potentially involved in metastatic invasion
Disease Models & Mechanisms, 2015 In the last decade, high-throughput chemical screening has become the dominant approach for discovering novel compounds with therapeutic properties. Automated screening using in vitro or cultured cell assays have yielded thousands of candidate drugs for ...Viviana E. Gallardo, Gaurav K. Varshney, Minnkyong Lee, Sujata Bupp, Lisha Xu, Paul Shinn, Nigel P. Crawford, James Inglese, Shawn M. Burgess +8 moredoaj +1 more sourceGenetic and Phenotypic Features of the Five Known Polyaminopathies: A Critical Narrative Review
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT
Polyaminopathies are a recently described family of rare genetic neurodevelopmental disorders. Polyaminopathies disrupt the biosynthesis of the primary polyamines: putrescine, spermidine, and spermine. Snyder–Robinson syndrome results from hemizygous loss‐of‐function variants in the spermine synthase (SMS) gene, resulting in decreased or ...Elizabeth A. VanSickle, Sara M. Sarasua, Tracy Lowe, Christopher L. Farrell, Luigi Boccuto, Charles Schwartz, Anthony E. Pegg, Angela Peron, Victor Faundes, Mythily Ganapathi, Wendy K. Chung, Alban Ziegler, Floris Hofstede, Clément Prouteau, Katharina Steindl, Colleen Olson, Orrin Devinsky, Teresa L. Mastracci, Robert A. Casero Jr., Tracy Murray Stewart, Susan Gilmour, Teri Koerner, Mary Jo Kutler, Surender Rajasekaran, Julianne Michael, André S. Bachmann, Caleb P. Bupp +26 morewiley +1 more sourceThe Clinical Spectrum and Neurodevelopmental Pathogenesis of KPTN‐Related Disorder in a Mouse Model
Annals of Neurology, EarlyView.Objective
Pathogenic variants in Kaptin (KPTN) cause KPTN‐related disorder (KRD). KPTN modulates mTOR signaling activation within the KICSTOR complex in response to cellular amino acid levels. We define the clinical spectrum and investigate the developmental pathogenesis of KRD.Lettie E. Rawlins, Philip H. Iffland II, John Page, Rebecca Z. Flessner, Soad M. Elziny, Irina Sbornova, Janice K. Babus, Sophie R. Bruckmeier, Ria Parikh, Merel Verhoeven, James Fasham, Joseph S. Leslie, Richard Caswell, Nishanka Ubeyratna, Olivia Wenger, Ethan M. Scott, John Schreiber, Steffen Syrbe, Annick Klabunde‐Cherwon, Martina Owens, Andrew H. Crosby, Emma L. Baple, Peter B. Crino, the KPTN Consortium, Andrea Seeley, Heather Rocha, Sabine Rudnick, Ulrich Schaatz, Tobias Haack, Eva Schwaibold, Caleb Bupp, Klaas Wierenga, John Schreiber, Thorkild Terkelsen, Sarina Kant, J. C. Herkert, Michael Wright, Boris Keren, Solveig Heide, Pamela Jackson, Pradeep Vasudevan, Helen Stewart, Perrine Charles, Andreas Hahn, Saskia Biskup, Inger‐Lise Mero, Martin Heier, Conny van Ravenswaaij‐Arts, Esther Nibbeling, Stephanie Efthymiou, Erum Afzal, Ian Ellis, Raza Maroofian, Almundher Al‐Maawali, David Coman, Anthony Morosini, Sajjad Biglari, Pooneh Nikuei, Saadet Mercimek‐Andrews, Prab Prabhakar, Raymond Louie, Kameryn Butler, Olivia Wenger, Ethan M. Scott, Andrea Seeley, Heather Rocha, Amber Begtrup, Sabine Rudnik, Ulrich Schatz, Tobias Haack, Eva Schwaibold, Caleb Bupp, Klaas Wierenga, John Schreiber, Thorkild Terkelsen, Sarina Kant, J. C. Herkert, Michael Wright, Boris Keren, Solveig Heide, Pamela Jackson, Pradeep Vasudevan, Helen Stewart, Perrine Charles, Andreas Hahn, Saskia Biskup, Inger‐Lise Mero, Martin Heier, Marijn Stokman, Conny van Ravenswaaij‐Arts, Esther Nibbeling, Stephanie Efthymiou, Erum Afzal, Kristina Zhelcheska, Henry Houlden, Ian Ellis, Reza Maroofian, Gholamreza Shariati, Hamid Galehdari, Almundher Al‐Maawali, Adila Al‐Kindi, Andrew Y. Shuen, Victoria Siu, Annick Klabunde‐Cherwon, Steffen Syrbe +104 morewiley +1 more source
