Results 111 to 120 of about 30,729 (226)

Bupropion Reduces Some of the Symptoms of Marihuana Withdrawal in Chronic Marihuana Users: A Pilot Study

open access: yesSubstance Abuse: Research and Treatment, 2012
Bupropion's (Zyban ® SR) effectiveness to treat symptoms experienced in marihuana withdrawal was tested in a double-blind, placebo-controlled study with chronic, heavy marihuana users.
David M. Penetar   +4 more
doaj   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). II. Treatments in more advanced clinical development

open access: yesEpilepsia, Volume 67, Issue 10, Page 5075-5125, October 2026.
Abstract This article summarizes data for 13 investigational treatments for which at least preliminary seizure outcome data in patients with epilepsy were reported at the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices held in Madrid, Spain, on May 3–6, 2026.
Meir Bialer   +7 more
wiley   +1 more source

Efficacy and safety of varenicline and bupropion, in combination and alone, for alcohol use disorder: a randomized, double-blind, placebo-controlled multicentre trialResearch in context

open access: yesThe Lancet Regional Health. Europe
Summary: Background: Alcohol use disorder (AUD) is associated with an enormous burden of disease and cost to society. The dopamine deficiency hypothesis posits that negative reinforcement generated by a low brain dopamine state drives ethanol intake ...
Bo Söderpalm   +10 more
doaj   +1 more source

Real‐World Outcomes of Telemedicine Shared Medical Appointments in Obesity Management

open access: yesObesity Science &Practice, Volume 12, Issue 5, October 2026.
ABSTRACT Introduction Shared Medical Appointments (SMAs) have recently emerged as a novel tool in weight management as they are efficient, bypass logistic barriers to physical attendance, decrease attrition, and are cost‐effective. This study aimed to observe outcomes among patients enrolled in an insurance‐based weight loss program, called Program for
Keerthana Haridas   +5 more
wiley   +1 more source

Concurrent Antidepressant Use and Metastasis Risk Among Women Receiving Tamoxifen for Breast Cancer: A Real‐World Cohort Study

open access: yesPsycho-Oncology, Volume 35, Issue 10, October 2026.
ABSTRACT Objective Concurrent use of antidepressants, particularly cytochrome P450 2D6 (CYP2D6) inhibitors, may reduce tamoxifen bioactivation and effectiveness. However, the clinical significance of this potential interaction remains inconclusive. This study examined whether concurrent antidepressant use is associated with increased metastasis risk ...
Shaimaa Elshafie   +4 more
wiley   +1 more source

Comprehensive in vitro profiling of traditional and emerging stimulants at monoamine transporters and the 5‐HT2A receptor

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 19, Page 5871-5894, October 2026.
A pharmacological profiling of 58 synthetic stimulants of various classes at dopamine, norepinephrine, and serotonin transporters and the 5‐HT2A receptor, most showing distinct class‐dependent profiles, with some indicating a high abuse potential. Background and Purpose New psychoactive substances (NPSs) often emerge on the illicit drug market with ...
Darta Stalberga   +9 more
wiley   +1 more source

From Real World Data to Real Impact: A Co‐Medication Framework for Lung Cancer to Advance DDI Assessment and Patient‐Centric Drug Development

open access: yesClinical and Translational Science, Volume 19, Issue 10, October 2026.
ABSTRACT Lung cancer predominantly affects older adults who already experience comorbidities and are at increased risk of drug–drug interactions (DDIs) due to polypharmacy. Traditional DDI assessments often do not fully capture complex co‐medication patterns observed in real‐world practice due to the risk of introducing confounding factors.
Mareena Biju   +6 more
wiley   +1 more source

Mental Health Disorders in End‐Stage Kidney Disease: A Narrative Review of Clinical Considerations for Integrated Management

open access: yesHemodialysis International, Volume 30, Issue 4, Page 679-688, October 2026.
ABSTRACT Introduction End stage kidney disease (ESKD) is associated with a high prevalence of depression and anxiety, arising from both biological factors and the psychosocial burden of chronic dialysis care. Approximately 25%–30% of dialysis patients experience clinically significant depressive symptoms when assessed by structured clinical interview ...
Kunal Malhotra   +2 more
wiley   +1 more source

All Is Relative—A Call for Considering “Physiologically Informed” Control Conditions to Improve the Mechanistic Understanding of the Effects of Physical Exercise on Cognition

open access: yesScandinavian Journal of Psychology, Volume 67, Issue 5, Page 1246-1266, October 2026.
ABSTRACT There is a growing interest in elucidating the mechanisms that drive the benefits of physical exercise on cognitive performance. A key element for a better understanding of a particular phenomenon (e.g., the mediators of the exercise‐cognition interaction) is the selection of an appropriate control condition/group as the basis for causal ...
Fabian Herold   +6 more
wiley   +1 more source

Efficacy and safety of bupropion in quality of life of cancer patients, a randomized double blind placebo controlled clinical trial

open access: yesJournal of Mazandaran University of Medical Sciences, 2019
Background and purpose: Decreasing the quality of life in cancer patients is an essential factor that influences their lives during the process of treatment and after that.
Saeid Azimi   +6 more
doaj  

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