Results 71 to 80 of about 33,357 (182)

Psychotropic Drugs for Older Adults With Psychiatric Disorders Presenting to the Emergency Department: Prescription Patterns and Treatment Outcomes

Psychiatric Research and Clinical Practice, EarlyView.
Objective A high proportion of patients presenting to Emergency Departments (EDs) consists of vulnerable elderly people. Mental illnesses are frequently related to advancing age, with difficult to detect symptoms. The aim of this study was to investigate psychiatric drug use by geriatric patients in an ED for whom a psychiatric consultation was needed,
Marianna Mazza, Marcello Covino, Francesco Maria Lisci, Caterina Brisi, Georgios D. Kotzalidis, Giuseppe Marano, Francesca Abate, Maria Benedetta Anesini, Gianluca Boggio, Michele Ciliberto, Valeria De Masi, Cecilia Falsini, Ester Maria Marzo, Sara Rossi, Maria Chiara Spera, Alberto Torresi, Benedetta Simeoni, Francesco Franceschi, Gabriele Sani   +18 more
wiley   +1 more source

A multicenter, randomised, double-blind, placebo-controlled, prospective crossover trial [PDF]

, 2017
Objective To evaluate the efficacy and safety of bupropion in the treatment of apathy in Huntington’s disease (HD). Methods In this phase 2b multicentre, double-blind, placebo-controlled crossover trial, individuals with HD and clinical signs of apathy ...
Fischer, Wilhelm, Gelderblom, Harald, Hoffmann, Rainer, McLean, Tim, Muetze, Lisanne, Priller, Josef [u.a.], Saft, Carsten, Wuestenberg, Torsten   +7 more
core   +1 more source

A Comprehensive CYP2D6 Drug–Drug–Gene Interaction Network for Application in Precision Dosing and Drug Development

Clinical Pharmacology &Therapeutics, Volume 117, Issue 6, Page 1718-1731, June 2025.
Conducting clinical studies on drug–drug‐gene interactions (DDGIs) and extrapolating the findings into clinical dose recommendations is challenging due to the high complexity of these interactions. Here, physiologically‐based pharmacokinetic (PBPK) modeling networks present a new avenue for exploring such complex scenarios, potentially informing ...
Simeon Rüdesheim, Helena Leonie Hanae Loer, Denise Feick, Fatima Zahra Marok, Laura Maria Fuhr, Dominik Selzer, Donato Teutonico, Annika R. P. Schneider, Juri Solodenko, Sebastian Frechen, Maaike van der Lee, Dirk Jan A. R. Moes, Jesse J. Swen, Matthias Schwab, Thorsten Lehr   +14 more
wiley   +1 more source

A Phenotyping Tool for Seven Cytochrome P450 Enzymes and Two Transporters: Application to Examine the Effects of Clopidogrel and Gemfibrozil

Clinical Pharmacology &Therapeutics, Volume 117, Issue 6, Page 1732-1742, June 2025.
Clinical cocktails for cytochrome P450 (CYP) phenotyping lack a marker for CYP2C8. We aimed to combine the CYP2C8 index drug repaglinide with the Geneva cocktail (caffeine/CYP1A2, bupropion/CYP2B6, flurbiprofen/CYP2C9, omeprazole/CYP2C19, dextromethorphan/CYP2D6, and midazolam/CYP3A4). We also included endogenous organic anion transporting polypeptide (
Laura Aurinsalo, Outi Lapatto‐Reiniluoto, Mika Kurkela, Mikko Neuvonen, Johanna I. Kiiski, Mikko Niemi, Aleksi Tornio, Janne T. Backman   +7 more
wiley   +1 more source

Bidirectional associations between adiposity and mental health: a prospective cohort study of the UK Biobank

Obesity, Volume 33, Issue 6, Page 1195-1206, June 2025.
Abstract Objective This study aimed to examine the bidirectional associations between indicators of adiposity and mental health. Methods Using longitudinal data from 60,319 UK Biobank participants, we explored the bidirectional associations between mental health (including neuroticism, recent depressive symptoms, probable depression status, stress ...
Meng Lv, Ying Li, Zihan Guo, Lu Ma, Lei Zhang   +4 more
wiley   +1 more source

Monitoring Serum Bisoprolol Concentrations in Patients With Heart Failure With Reduced Ejection Fraction: Results of a Pilot Study From Routine Health Care

Pharmacology Research &Perspectives, Volume 13, Issue 3, June 2025.
ABSTRACT Bisoprolol is a second‐generation, highly selective beta‐1 adrenergic receptor antagonist with various beneficial effects in patients with heart failure. Interindividual variability in response to bisoprolol is known, and finding the optimal dose for individual patients with heart failure is still challenging.
Ivana Kacirova, Marie Lazarova, Romana Urinovska, Jozef Dodulik, Diana Drienikova, Jan Vaclavik   +5 more
wiley   +1 more source

Cerebrospinal Fluid Biomarkers in Opioid Dependence: Evidence of Neuroimmune Activation and Ion Composition Changes, Without Alteration in Orexin‐A

Addiction Biology, Volume 30, Issue 6, June 2025.
Cerebrospinal fluid from individuals with opioid dependence shows elevated neuroinflammatory biomarkers, indicating CNS immune activation. ABSTRACT Opioid abuse is a severe global health challenge, leading to rising morbidity, mortality, and increasing societal costs.
Tim Lyckenvik, Malin Woock, Kalle Johansson, Markus Axelsson, Henrik Zetterberg, Kaj Blennow, Eric Hanse, Pontus Wasling   +7 more
wiley   +1 more source

Misdiagnosis of Bupropion Intoxication

Journal of Medical Cases, 2015
Bupropion inhibits catecholamine’s neuronal reuptake selectively but has a minimal effect on indolamine reuptake. It can be used in the treatment of major depressive disorder. A 3.5-year-old 15 kg girl had vomiting and disorders in her speech. After a time, she did not take breath and stared at one point and had a seizure.
ACAR, TARIK, ERGİN, MEHMET, CANDER, BAŞAR, ŞAHİN, SÜLEYMAN, ÇAKSEN, HÜSEYİN, KUTLU, NURETTİN ONUR   +5 more
openaire   +4 more sources

Setting of initiation and factors associated with antidepressant use on entry to long‐term care facilities

British Journal of Clinical Pharmacology, Volume 91, Issue 6, Page 1749-1759, June 2025.
Abstract Aims Antidepressant use increases around long‐term care facility (LTCF) entry, and initiation during hospitalizations may contribute to this. This study characterized the care setting (i.e., community‐based, hospital or LTCF) where antidepressants were initiated and determined associated resident characteristics.
Georgina A. Hughes, Maria C. Inacio, Debra Rowett, Catherine Lang, Robert N. Jorissen, Megan Corlis, Janet K. Sluggett   +6 more
wiley   +1 more source

Comprehensive Characterization of Antidepressant Pharmacogenetics: A Systematic Review of Studies in Major Depressive Disorder

Clinical and Translational Science, Volume 18, Issue 6, June 2025.
ABSTRACT Pharmacogenetics is a promising strategy to facilitate individualized care for patients with Major Depressive Disorder (MDD). Research is ongoing to identify the optimal genetic markers for predicting outcomes to antidepressant therapies. The primary aim of this systematic review was to summarize antidepressant pharmacogenetic studies to ...
Caroline W. Grant, Karina Delaney, Linsey E. Jackson, Justin Bobo, Leslie C. Hassett, Liewei Wang, Richard M. Weinshilboum, Paul E. Croarkin, Melanie T. Gentry, Ann M. Moyer, Arjun P. Athreya   +10 more
wiley   +1 more source