Results 71 to 80 of about 6,089 (200)

Exploring phage–host interactions in Burkholderia cepacia complex bacterium to reveal host factors and phage resistance genes using CRISPRi functional genomics and transcriptomics

Microbiology Spectrum
Complex interactions of bacteriophages with their bacterial hosts determine phage host range and infectivity. While phage defense systems and host factors have been identified in model bacteria, they remain challenging to predict in non-model bacteria ...
Ben Diaz, Rohan Krishna, Joseph S. Schoeniger, Catherine M. Mageeney   +3 more
doaj   +1 more source

Burkholderia cenocepacia Vaginal Infection in Patient with Smoldering Myeloma and Chronic Hepatitis C

Emerging Infectious Diseases, 2004
We report a case of a vaginal infection caused by a strain of Burkholderia cenocepacia. The strain was isolated from vaginal swab specimens from a 68-year-old woman with smoldering myeloma and chronic hepatitis C virus infection who was hospitalized for ...
Andrea Petrucca, Paola Cipriani, Rosa Sessa, Antonella Teggi, Rosalia Pustorino, Daniela Santapaola, Mauro Nicoletti   +6 more
doaj   +1 more source

Inactivation of Rho GTPases by Burkholderia cenocepacia Induces a WASH-Mediated Actin Polymerization that Delays Phagosome Maturation

Cell Reports, 2020
Summary: Burkholderia cenocepacia is an opportunistic bacterial pathogen that causes severe pulmonary infections in cystic fibrosis and chronic granulomatous disease patients. B.
Glenn F.W. Walpole, Jonathan D. Plumb, Daniel Chung, Brandon Tang, Benoit Boulay, Douglas G. Osborne, Joshua T. Piotrowski, Sergio D. Catz, Daniel D. Billadeau, Sergio Grinstein, Valentin Jaumouillé   +10 more
doaj   +1 more source

High Confidence Prediction of Essential Genes in Burkholderia Cenocepacia

PLoS ONE, 2012
BACKGROUND: Essential genes are absolutely required for the survival of an organism. The identification of essential genes, besides being one of the most fundamental questions in biology, is also of interest for the emerging science of synthetic biology and for the development of novel antimicrobials.
Mario Juhas, Manuel Stark, Christian von Mering, Puthapoom Lumjiaktase, Derrick W. Crook, Miguel A. Valvano, Leo Eberl   +6 more
openaire   +6 more sources

The changing epidemiology of Burkholderia species infection at an adult cystic fibrosis centre

, 2008
Background: This study reviews the impact of changing infection control practices at the Manchester Adult Cystic Fibrosis Centre (MACFC) upon the epidemiology of Burkholderia species infections.Methods: We reviewed strain and genomovar typing of all ...
Doherty, Catherine J., Govan, John R., Dodd, Mary E., Webb, A. K., Jones, Andrew M., France, Megan W.   +5 more
core   +1 more source

CD4+ T cell epitopes of FliC conserved between strains of Burkholderia: implications for vaccines against melioidosis and cepacia complex in cystic fibrosis.

, 2014
Burkholderia pseudomallei is the causative agent of melioidosis characterized by pneumonia and fatal septicemia and prevalent in Southeast Asia. Related Burkholderia species are strong risk factors of mortality in cystic fibrosis (CF).
Nithichanon, Arnone, Lertmemongkolchai, Ganjana, Chu, Karen KY, Khaenam, Prasong, Rinchai, Darawan, Maillere, Bernard, Robinson, John H, Favry, Emmanuel, Bancroft, Gregory J, Reynolds, Catherine J, Altmann, Daniel M, Spink, Natasha, Boyton, Rosemary J, Musson, Julie A, De Soyza, Anthony   +14 more
core   +1 more source

Characterization of the Burkholderia cenocepacia J2315 Surface-Exposed Immunoproteome [PDF]

Vaccines, 2020
Infections by the Burkholderia cepacia complex (Bcc) remain seriously life threatening to cystic fibrosis (CF) patients, and no effective eradication is available. A vaccine to protect patients against Bcc infections is a highly attractive therapeutic option, but none is available.
Sílvia A. Sousa, António M.M. Seixas, Manoj Mandal, Manuel J. Rodríguez-Ortega, Jorge H. Leitão   +4 more
openaire   +5 more sources

Gasdermin D restricts Burkholderia cenocepacia infection in vitro and in vivo

Scientific Reports, 2021
Burkholderia cenocepacia (B. cenocepacia) is an opportunistic bacterium; causing severe life threatening systemic infections in immunocompromised individuals including cystic fibrosis patients.
Shady Estfanous, Kathrin Krause, Midhun N. K. Anne, Mostafa Eltobgy, Kyle Caution, Arwa Abu Khweek, Kaitlin Hamilton, Asmaa Badr, Kylene Daily, Cierra Carafice, Daniel Baetzhold, Xiaoli Zhang, Tianliang Li, Haitao Wen, Mikhail A. Gavrilin, Hesham Haffez, Sameh Soror, Amal O. Amer   +17 more
doaj   +1 more source

Acute Burkholderia cenocepacia pyomyositis in a patient with cystic fibrosis [PDF]

Journal of Cystic Fibrosis, 2009
Extra-pulmonary complications of Burkholderia cepacia complex (Bcc) infection in patients with cystic fibrosis are unusual. To the best of the authors' knowledge no case of pyomyositis secondary to Bcc infection has been reported previously.We report a case of pyomyositis of the forearm caused by Bcc infection in a patient with CF.
El-Laboudi, A.H., Etherington, C., Whitaker, P., Clifton, I.J., Conway, S.P., Denton, M., Peckham, D.G.   +6 more
openaire   +2 more sources

Genome‐Wide In Silico Analysis of the Type VI Secretion System (T6SS) Within the Morganella Genus

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
▪ Species‐specific T6SS patterns among Morganella genus (M. morganii and M. sibonii). ▪ Only one‐third of M. morganii isolates haboured a T6SS. ▪ All M. sibonii possess four T6SS clusters. ▪ M. sibonii exhibited a wide diversity of effectors compared to M. morganii.
Mathilde Duque, Aymeric Jacquemin, Delphine Girlich, Rémy A. Bonnin, Laurent Dortet   +4 more
wiley   +1 more source