Results 51 to 60 of about 4,698 (167)

Inactivation of Rho GTPases by Burkholderia cenocepacia Induces a WASH-Mediated Actin Polymerization that Delays Phagosome Maturation

Cell Reports, 2020
Summary: Burkholderia cenocepacia is an opportunistic bacterial pathogen that causes severe pulmonary infections in cystic fibrosis and chronic granulomatous disease patients. B.
Glenn F.W. Walpole, Jonathan D. Plumb, Daniel Chung, Brandon Tang, Benoit Boulay, Douglas G. Osborne, Joshua T. Piotrowski, Sergio D. Catz, Daniel D. Billadeau, Sergio Grinstein, Valentin Jaumouillé   +10 more
doaj   +1 more source

Characterization of the Burkholderia cenocepacia J2315 Surface-Exposed Immunoproteome [PDF]

Vaccines, 2020
Infections by the Burkholderia cepacia complex (Bcc) remain seriously life threatening to cystic fibrosis (CF) patients, and no effective eradication is available. A vaccine to protect patients against Bcc infections is a highly attractive therapeutic option, but none is available.
Sílvia A. Sousa, António M.M. Seixas, Manoj Mandal, Manuel J. Rodríguez-Ortega, Jorge H. Leitão   +4 more
openaire   +5 more sources

A cofactor‐promiscuous HMGR from the Lyme disease pathogen illuminates diversity in bacterial isoprenoid biosynthesis

Protein Science, Volume 35, Issue 9, September 2026.
Abstract The Lyme disease pathogen Borrelia burgdorferi contains a highly reduced genome lacking many primary metabolic pathways. However, B. burgdorferi retains the mevalonate pathway that synthesizes isopentenyl pyrophosphate (IPP), the precursor to the peptidoglycan carrier lipid.
Isaac A. Paddy, Joshua McCausland, Madelyn Frazier, Poulami Chatterjee, Mekedlawit Setegne, Oliv Eidam, Christine Jacobs‐Wagner, Laura M. K. Dassama   +7 more
wiley   +1 more source

Acute Burkholderia cenocepacia pyomyositis in a patient with cystic fibrosis [PDF]

Journal of Cystic Fibrosis, 2009
Extra-pulmonary complications of Burkholderia cepacia complex (Bcc) infection in patients with cystic fibrosis are unusual. To the best of the authors' knowledge no case of pyomyositis secondary to Bcc infection has been reported previously.We report a case of pyomyositis of the forearm caused by Bcc infection in a patient with CF.
El-Laboudi, A.H., Etherington, C., Whitaker, P., Clifton, I.J., Conway, S.P., Denton, M., Peckham, D.G.   +6 more
openaire   +2 more sources

To Move or Not to Move: When and How Bacteria Suppress Flagellar Motility

Molecular Microbiology, Volume 126, Issue 2, Page 173-189, August 2026.
Motility cessation in bacteria is a key regulatory strategy that provides multiple survival advantages including enhanced community cooperation, niche adaptation and evasion of host immune responses. This process is controlled by associated mechanisms such as post‐translational modifications and second messenger signalling that stabilise non‐motile ...
Fatemeh Mohaghegh, Jacob Scadden, Matthew A. B. Baker   +2 more
wiley   +1 more source

A rhizospheric Burkholderia cepacia complex population: genotypic and phenotypic diversity of Burkholderia cenocepacia and Burkholderia ambifaria [PDF]

FEMS Microbiology Ecology, 2003
The Burkholderia cepacia'complex' (Bcc) presently comprises nine species and genomovars. In order to acquire a better comprehension of the species and genomovar distribution and of the genetic diversity among environmental Bcc bacteria, a natural population of 60 bacterial isolates recovered from the rhizosphere of maize and belonging to the Bcc has ...
Dalmastri, Claudia, Fiore, Alessia, Alisi, Chiara, Bevivino, Annamaria, Tabacchioni, Silvia, Giuliano, Giovanni, Sprocati, Anna Rosa, Segre, Lia, Mahenthiralingam, Eshwar, Chiarini, Luigi, Vandamme, Peter   +10 more
openaire   +3 more sources

Gasdermin D restricts Burkholderia cenocepacia infection in vitro and in vivo

Scientific Reports, 2021
Burkholderia cenocepacia (B. cenocepacia) is an opportunistic bacterium; causing severe life threatening systemic infections in immunocompromised individuals including cystic fibrosis patients.
Shady Estfanous, Kathrin Krause, Midhun N. K. Anne, Mostafa Eltobgy, Kyle Caution, Arwa Abu Khweek, Kaitlin Hamilton, Asmaa Badr, Kylene Daily, Cierra Carafice, Daniel Baetzhold, Xiaoli Zhang, Tianliang Li, Haitao Wen, Mikhail A. Gavrilin, Hesham Haffez, Sameh Soror, Amal O. Amer   +17 more
doaj   +1 more source

Thioredoxin Reductase as a Target for Antibacterial Gold Compounds in Burkholderia cenocepacia: Disclosing the Molecular Basis of Enzyme Inhibition

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
The molecular basis of thioredoxin reductase inhibition by antibacterial gold(I) compounds is disclosed. X‐ray crystallography and high‐resolution ESI‐MS reveal selective gold coordination to catalytically relevant cysteine residues of Bc‐TrxR, leading to stable protein–gold adducts and disruption of enzyme redox activity.
Stefano Zineddu, José Aleixo de Azevedo‐França, Martina Aguanno, Valentina Pecchioli, Giarita Ferraro, Virginia Cuomo, Antonello Merlino, Luigi Messori   +7 more
wiley   +1 more source

Genome‐Wide In Silico Analysis of the Type VI Secretion System (T6SS) Within the Morganella Genus

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
▪ Species‐specific T6SS patterns among Morganella genus (M. morganii and M. sibonii). ▪ Only one‐third of M. morganii isolates haboured a T6SS. ▪ All M. sibonii possess four T6SS clusters. ▪ M. sibonii exhibited a wide diversity of effectors compared to M. morganii.
Mathilde Duque, Aymeric Jacquemin, Delphine Girlich, Rémy A. Bonnin, Laurent Dortet   +4 more
wiley   +1 more source

Unravelling resistance in Burkholderia cenocepacia: Multi-omic insights into genetic and transcriptomic adaptations to sub-inhibitory antibiotic stress

Journal of Global Antimicrobial Resistance
AIM: To elucidate the molecular mechanisms driving the resistance phenotype of (Burkholderia cenocepacia under sub-inhibitory antibiotic stress BACKGROUND: The Burkholderia cepacia complex (BCC) includes 20 species of non-fermenting gram-negative ...
Himanshu Joshi, Amit Arora
doaj   +1 more source