Effect of β-lactamase inhibitors on in vitro activity of β-lactam antibiotics against Burkholderia cepacia complex species [PDF]
Background: Bacteria belonging to the Burkholderia cepacia complex (Bcc) are an important cause of chronic respiratory tract infections in cystic fibrosis patients. Intrinsic resistance to a wide range of antimicrobial agents, including a variety of beta-
Coenye, Tom, Everaert, Annelien
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An unusual case of primary melioidotic prostatic abscess complicated by perianal abscess
Burkholderia pseudomallei is recognized to cause severe and fatal infections. Most of the infections caused by this facultative intracellular gram-negative bacterium are pneumonia, soft tissue, genito-urinary and central nervous system infection.
Y.C. Chee, Y.N. Chee
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In vitro activity of ceftazidime, ciprofloxacin, meropenem, minocycline, tobramycin and trimethoprim/sulfamethoxazole against planktonic and sessile Burkholderia cepacia complex bacteria [PDF]
Objectives: The goal of the present study was to obtain a comprehensive overview of the bacteriostatic and bactericidal effects of six commonly used antibiotics on planktonic as well as on sessile Burkholderia cepacia complex cells.
Coenye, Tom, Nelis, Hans, Peeters, Elke
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Synovial Tissue Infection withBurkholderia fungorum [PDF]
To the Editor: The genus Burkholderia, first proposed in 1992, has now expanded to consist of many species (1). Bacteria of this genus exhibit extensive ubiquity; they have been isolated from human, animal, and environmental sources (1,2). Although rare, Burkholderia fungorum has been implicated in several human infections (2–4).
Shih Keng Loong +4 more
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Consequences of cystic fibrosis transmembrane regulator mutations on inflammatory cells [PDF]
Recent studies in cystic fibrosis (CF) transmembrane regulator (CFTR) mutations and function have shed light on its involvement in disease progression. The extent of cell and tissue distribution of CFTR facilitates systemic dysfunction of ion transport ...
Castro, Guillermo Raul +2 more
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The role of small proteins in Burkholderia cenocepacia J2315 biofilm formation, persistence and intracellular growth [PDF]
Burkholderia cenocepacia infections are difficult to treat due to resistance, biofilm formation and persistence. B. cenocepacia strain J2315 has a large multi-replicon genome (8.06 Mb) and the function of a large fraction of (conserved) hypothetical ...
Braeckmans, Kevin +12 more
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Symmetrical peripheral gangrene with Burkholderia multivorans infection
Burkholderia multivorans is an opportunistic pathogen that is commonly found in immunocompromised patients. This article reports a case of Symmetrical peripheral gangrene with Burkholderia multivorans infection. The patient presented with symmetrical peripheral gangrene, and the infection was confirmed through blood culture and peripheral blood next ...
S. Steve Yan, Juntao Meng, S Li
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An international, multicentre evaluation and description of Burkholderia pseudomallei infection in cystic fibrosis [PDF]
BACKGROUND: Several cases of Burkholderia pseudomallei infection in CF have been previously reported. We aimed to identify all cases globally, risk factors for acquisition, clinical consequences, and optimal treatment strategies.
Bell, SC +3 more
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Genome-wide transcription start site profiling in biofilm-grown Burkholderia cenocepacia J2315 [PDF]
Background: Burkholderia cenocepacia is a soil-dwelling Gram-negative Betaproteobacterium with an important role as opportunistic pathogen in humans. Infections with B.
Coenye, Tom +6 more
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Burkholderia cepacia Complex Vaccines: Where Do We Go from here?
Burkholderia comprises a wide variety of environmental Gram-negative bacteria. Burkholderia cepacia complex (Bcc) includes several Burkholderia species that pose a health hazard as they are able to cause respiratory infections in patients with chronic ...
Gonzalo A. Pradenas +2 more
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