Results 61 to 70 of about 2,537 (162)

Development of novel O-polysaccharide based glycoconjugates for immunization against glanders

Frontiers in Cellular and Infection Microbiology, 2012
Burkholderia mallei, the etiologic agent of glanders, causes severe disease in humans and animals and is a potential agent of biological warfare and terrorism. Diagnosis and treatment of glanders can be challenging, and in the absence of chemotherapeutic
Mary N Burtnick, Christian eHeiss, A. Michele eSchuler, Parastoo eAzadi, Paul J Brett   +4 more
doaj   +1 more source

The Burkholderia thailandensis Phages ΦE058 and ΦE067 Represent Distinct Prototypes of a New Subgroup of Temperate Burkholderia Myoviruses

Frontiers in Microbiology, 2020
Burkholderia mallei and B. pseudomallei are highly pathogenic species which are closely related, but diverse regarding their prophage content. While temperate phages have not yet been isolated from B. mallei, several phages of B.
Jens A. Hammerl, Sven Volkmar, Daniela Jacob, Iris Klein, Claudia Jäckel, Stefan Hertwig   +5 more
doaj   +1 more source

Genomic structure of Burkholderia mallei Razi 325, the strain used for industrial production of Mallein in Iran

مجله دانشگاه علوم پزشکی گرگان, 2016
Background and Objective: Iran remains a major stronghold for glanders in the Middle East. In Iran, the non-indigenous Burkholderia mallei Razi 325 strain is used in manufacturing of the mallein, required for malleination of animals. Multi Locus Variable
E Faraj Tabrizi, K Tadayon, N Mosavari, Tajbakhsh E, Keshavarz R, Ghaderi R, Sekhavati M, Banihashemi R, Najafpour R, Mohrekesh Haghighat M, Dehghanpour M   +10 more
doaj  

Drug Design and Delivery for Intracellular Bacteria: Emerging Paradigms

Drug Development Research, Volume 86, Issue 8, December 2025.
ABSTRACT Intracellular bacteria exploit host cell niches, such as lysosomes, phagosomes, cytosol, entire cells, and even erythrocytes, to evade immune clearance and escape conventional antibiotics. These environments pose numerous therapeutic challenges, including crossing host cell membranes, navigating endosomal trafficking, tolerating acidic and ...
Babatunde Ibrahim Olowu, Maryam Ebunoluwa Zakariya, Abdulmuheez Abiola Abdulkareem, Olalekan Toheeb Okewale, Muhammad Halima Idris, Halimah Oluwayemisi Olayiwola   +5 more
wiley   +1 more source

Identification of Burkholderia mallei and Burkholderia pseudomallei adhesins for human respiratory epithelial cells [PDF]

BMC Microbiology, 2010
AbstractBackgroundBurkholderia pseudomalleiandBurkholderia malleicause the diseases melioidosis and glanders, respectively. A well-studied aspect of pathogenesis by these closely-related bacteria is their ability to invade and multiply within eukaryotic cells. In contrast, the means by whichB. pseudomalleiandB. malleiadhere to cells are poorly defined.
Hogan Robert J, Wooten Ronald M, Grose William, Lazarus John J, Lipski Serena, Balder Rachel, Woods Donald E, Lafontaine Eric R   +7 more
openaire   +3 more sources

DBSecSys: a database of Burkholderia malleisecretion systems [PDF]

BMC Bioinformatics, 2014
Bacterial pathogenicity represents a major public health concern worldwide. Secretion systems are a key component of bacterial pathogenicity, as they provide the means for bacterial proteins to penetrate host-cell membranes and insert themselves directly into the host cells' cytosol.
Vesna Memievi, Kamal Kumar 0002, Li Cheng, Nela Zavaljevski, David DeShazer, Anders Wallqvist, Jaques Reifman   +6 more
openaire   +2 more sources

The early stage of bacterial genome-reductive evolution in the host.

PLoS Pathogens, 2010
The equine-associated obligate pathogen Burkholderia mallei was developed by reductive evolution involving a substantial portion of the genome from Burkholderia pseudomallei, a free-living opportunistic pathogen.
Han Song, Junghyun Hwang, Hyojeong Yi, Ricky L Ulrich, Yan Yu, William C Nierman, Heenam Stanley Kim   +6 more
doaj   +1 more source

Glanders Diagnosis in an Asymptomatic Mare from Brazil: Insights from Serology, Microbiological Culture, Mass Spectrometry, and Genome Sequencing

Pathogens, 2023
This manuscript elucidates the occurrence of glanders in an asymptomatic mare from Brazil presenting positive Burkholderia mallei antibody titers. The diagnosis was established through a multi-pronged approach encompassing microbiological culture, mass ...
Paula Adas Pereira Suniga, Cynthia Mantovani, Maria Goretti dos Santos, Andréa Alves do Egito, Newton Valério Verbisck, Lenita Ramires dos Santos, Alberto Martín Rivera Dávila, Cristina Kraemer Zimpel, Maria Carolina Sisco Zerpa, Daniela Pontes Chiebao, Ana Márcia de Sá Guimarães, Alessandra Figueiredo de Castro Nassar, Flábio Ribeiro de Araújo   +12 more
doaj   +1 more source

Bacterial Outer Membrane Vesicles: From Physics to Clinical

MedComm – Biomaterials and Applications, Volume 4, Issue 2, June 2025.
A review of an introduction to the mechanisms of formation of OMVs, their action on bacteria and relationship to disease, vaccines, biomonitoring, drug delivery and regenerative medicine in the clinic. ABSTRACT Bacterial outer membrane vesicles (OMVs) are nanoscale vesicular structures naturally produced by Gram‐negative bacteria during growth.
Jun Zhou, Shuang Zou, Derong Dai, Liqing He, Xingyu Mou, Ninglin Zhao, Hong Li, Rui Bao   +7 more
wiley   +1 more source

Polysaccharide microarray technology for the detection of Burkholderia pseudomallei and Burkholderia mallei antibodies

Diagnostic Microbiology and Infectious Disease, 2006
A polysaccharide microarray platform was prepared by immobilizing Burkholderia pseudomallei and Burkholderia mallei polysaccharides. This polysaccharide array was tested with success for detecting B. pseudomallei and B. mallei serum (human and animal) antibodies.
Parthasarathy, Narayanan, DeShazer, David, England, Marilyn, Waag, David M.   +3 more
openaire   +2 more sources