Results 41 to 50 of about 2,537 (162)

The possibility of identifying individual strains of glanders and melioidosis pathogens with a combination of immunoblotting and DNA amplification methods

Инфекция и иммунитет, 2019
Causative agents of melioidosis and glanders are among the most dangerous bacterial pathogens for human. Moreover, Burkholderia pseudomallei and Burkholderia mallei are considered to be potential bioterrorism agents.
S. S. Vetchinin, I. Yu. Shchit, A. G. Shevyakov, S. F. Biketov   +3 more
doaj   +1 more source

Glanders: off to the races withBurkholderia mallei [PDF]

FEMS Microbiology Letters, 2007
Burkholderia mallei, the etiologic agent of the disease known as glanders, is primarily a disease affecting horses and is transmitted to humans by direct contact with infected animals. The use of B. mallei as a biological weapon has been reported and currently, there is no vaccine available for either humans or animals.
Gregory C, Whitlock, D Mark, Estes, Alfredo G, Torres   +2 more
openaire   +2 more sources

Burkholderia Vaccines: Are We Moving Forward?

Frontiers in Cellular and Infection Microbiology, 2013
The genus Burkholderia consists of diverse species which includes both ‘friends’ and ‘foes’. Some of the ‘friendly’ Burkholderia spp. are extensively used in the biotechnological and agricultural industry for bioremediation and biocontrol.
Leang-Chung eChoh, Guang-Han eOng, Kumutha Malar Vellasamy, Kaveena eKalaiselvam, Wen-Tyng eKang, Anis Rageh Al-Maleki, Vanitha eMariappan, Jamuna eVadivelu   +7 more
doaj   +1 more source

Structural flexibility in the Burkholderia mallei genome [PDF]

Proceedings of the National Academy of Sciences, 2004
The complete genome sequence of Burkholderia mallei ATCC 23344 provides insight into this highly infectious bacterium's pathogenicity and evolutionary history. B. mallei , the etiologic agent of glanders, has come under renewed scientific investigation ...
William C, Nierman, David, DeShazer, H Stanley, Kim, Herve, Tettelin, Karen E, Nelson, Tamara, Feldblyum, Ricky L, Ulrich, Catherine M, Ronning, Lauren M, Brinkac, Sean C, Daugherty, Tanja D, Davidsen, Robert T, Deboy, George, Dimitrov, Robert J, Dodson, A Scott, Durkin, Michelle L, Gwinn, Daniel H, Haft, Hoda, Khouri, James F, Kolonay, Ramana, Madupu, Yasmin, Mohammoud, William C, Nelson, Diana, Radune, Claudia M, Romero, Saul, Sarria, Jeremy, Selengut, Christine, Shamblin, Steven A, Sullivan, Owen, White, Yan, Yu, Nikhat, Zafar, Liwei, Zhou, Claire M, Fraser   +32 more
openaire   +2 more sources

Virulence of Burkholderia mallei Quorum-Sensing Mutants [PDF]

Infection and Immunity, 2013
ABSTRACT Many Proteobacteria use acyl-homoserine lactone-mediated quorum-sensing (QS) to activate specific sets of genes as a function of cell density. QS often controls the virulence of pathogenic species, and in fact a previous study indicated that QS was important for Burkholderia mallei
Charlotte, Majerczyk, Loren, Kinman, Tony, Han, Richard, Bunt, E Peter, Greenberg   +4 more
openaire   +2 more sources

Antibodies Are Major Drivers of Protection against Lethal Aerosol Infection with Highly Pathogenic Burkholderia spp

mSphere, 2019
Burkholderia pseudomallei and Burkholderia mallei are the causative agents of melioidosis and glanders, respectively. There is no vaccine to protect against these highly pathogenic bacteria, and there is concern regarding their emergence as global public
Robert J. Hogan, Eric R. Lafontaine
doaj   +1 more source

Inactivation of the Burkholderia Toxin Malleicyprol by Enzymatic Cyclopropanol Ring Opening

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
Burkholderia pseudomallei and Burkholderia mallei are dangerous pathogens that cause severe diseases with high mortality rates. Their virulence relies in part on malleicyprols, potent toxins containing a highly reactive cyclopropanol group. In this study, we identify BurK, a heme‐dependent oxidoreductase that neutralizes malleicyprols by enzymatically ...
Jonas Fiedler, Ingrid Richter, Katharina Dornblut, Alicia Scharf, Christian Hertweck   +4 more
wiley   +2 more sources

Detection and differentiation of Burkholderia species with pathogenic potential in environmental soil samples.

PLoS ONE, 2021
The Burkholderia pseudomallei phylogenetic cluster includes B. pseudomallei, B. mallei, B. thailandensis, B. oklahomensis, B. humptydooensis and B. singularis. Regarded as the only pathogenic members of this group, B. pseudomallei and B. mallei cause the
Sujintana Janesomboon, Veerachat Muangsombut, Varintip Srinon, Chatruthai Meethai, Chayada S Tharinjaroen, Premjit Amornchai, Patoo Withatanung, Narisara Chantratita, Mark Mayo, Vanaporn Wuthiekanun, Bart J Currie, Joanne M Stevens, Sunee Korbsrisate   +12 more
doaj   +1 more source

Antigenic Relatedness between Burkholderia pseudomallei and Burkholderia mallei [PDF]

Microbiology and Immunology, 2002
AbstractBurkholderia pseudomallei and Burkholderia mallei are causative agents of distinct diseases, namely, melioidosis and glanders, respectively. The two species are very closely related, based on DNA‐DNA homology, base sequence of the 16S rRNA, and phenotypic characteristics. Based on the use of polyclonal antisera, B. pseudomallei and B.
Narisara, Anuntagool, Stitaya, Sirisinha
openaire   +2 more sources

Thiotemplated Polyketide Chain Fusion and Reductive Cyclization Build the Reactive Butenolide Core of Malleicyprol

Angewandte Chemie, Volume 137, Issue 31, July 28, 2025.
Malleicyprol, a virulence factor of notorious animal and human pathogens of the Burkholderia pseudomallei (BP) group, results from the fusion of two individual polyketide chains. The noncanonical condensation domain of the PKS–NRPS hybrid synthetase BurF forms an ester bond, and the terminal reductase domain mediates a reductive chain release followed ...
Jonas Fiedler, Leo Dumjahn, Mie Ishida‐Ito, Felix Trottmann, Keishi Ishida, Christian Hertweck   +5 more
wiley   +2 more sources