From Prevention to Disease Perturbations: A Multi-Omic Assessment of Exercise and Myocardial Infarctions [PDF]
Biomolecules, 2020 While a molecular assessment of the perturbations and injury arising from diseases is essential in their diagnosis and treatment, understanding changes due to preventative strategies is also imperative.
Melanie T. Odenkirk +7 more
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Itaconic acid production is regulated by LaeA in Aspergillus pseudoterreus [PDF]
Metabolic Engineering Communications, 2022 The global regulator LaeA controls secondary metabolism in diverse Aspergillus species. Here we explored its role in regulation of itaconic acid production in Aspergillus pseudoterreus.
Kyle R. Pomraning +17 more
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Elucidating regulatory processes of intense physical activity by multi-omics analysis [PDF]
Military Medical Research, 2023 Background Physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations, such as firefighting, law enforcement, military, and sports.
Ernesto S. Nakayasu +19 more
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Multi-Omics Driven Metabolic Network Reconstruction and Analysis of Lignocellulosic Carbon Utilization in Rhodosporidium toruloides [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 An oleaginous yeast Rhodosporidium toruloides is a promising host for converting lignocellulosic biomass to bioproducts and biofuels. In this work, we performed multi-omics analysis of lignocellulosic carbon utilization in R. toruloides and reconstructed
Joonhoon Kim +30 more
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Evaluation of chromosomal insertion loci in the Pseudomonas putida KT2440 genome for predictable biosystems design [PDF]
Metabolic Engineering Communications, 2020 The development of Pseudomonas strains for industrial production of fuels and chemicals will require the integration of heterologous genes and pathways into the chromosome.
Julie E. Chaves +13 more
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Advanced multi-modal mass spectrometry imaging reveals functional differences of placental villous compartments at microscale resolution [PDF]
Nature CommunicationsThe placenta is a complex and heterogeneous organ that links the mother and fetus, playing a crucial role in nourishing and protecting the fetus throughout pregnancy. Integrative spatial multi-omics approaches can provide a systems-level understanding of
Marija Veličković +15 more
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Enabling malic acid production from corn-stover hydrolysate in Lipomyces starkeyi via metabolic engineering and bioprocess optimization [PDF]
Microbial Cell FactoriesBackground Lipomyces starkeyi is an oleaginous yeast with a native metabolism well-suited for production of lipids and biofuels from complex lignocellulosic and waste feedstocks.
Jeffrey J. Czajka +15 more
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Muconic acid production from glucose and xylose in Pseudomonas putida via evolution and metabolic engineering [PDF]
Nature Communications, 2022 Muconic acid is a platform chemical with wide industrial applicability. Here, the authors report efficient muconate production from glucose and xylose by engineered Pseudomonas putida strain using adaptive laboratory evolution, metabolic modeling, and ...
Chen Ling +16 more
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PeakDecoder enables machine learning-based metabolite annotation and accurate profiling in multidimensional mass spectrometry measurements [PDF]
Nature Communications, 2023 Multidimensional measurements using state-of-the-art separations and mass spectrometry provide advantages in untargeted metabolomics analyses for studying biological and environmental bio-chemical processes.
Aivett Bilbao +27 more
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Unfolded Protein Response Inhibition Reduces Middle East Respiratory Syndrome Coronavirus-Induced Acute Lung Injury [PDF]
mBio, 2021 Tissue- and cell-specific expression patterns are highly variable within and across individuals, leading to altered host responses after acute virus infection.
Amy C. Sims +13 more
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