Results 171 to 180 of about 25,232 (222)
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Annals of Pharmacotherapy, 1994
OBJECTIVE: To review the current published studies evaluating the pharmacokinetics, clinical efficacy, safety, and toxicity of busulfan in pediatric and adult patients. DATA SOURCES: English-language literature published between 1953 ...
Buggia, I +3 more
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OBJECTIVE: To review the current published studies evaluating the pharmacokinetics, clinical efficacy, safety, and toxicity of busulfan in pediatric and adult patients. DATA SOURCES: English-language literature published between 1953 ...
Buggia, I +3 more
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Journal of food biochemistry, 2022
Previous reports revealed that increased oxidative stress with up-regulated inflammatory proteins and apoptotic factors have serious implications in busulfan-induced chemo-brain and testicular damages.
E. Tesi +9 more
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Previous reports revealed that increased oxidative stress with up-regulated inflammatory proteins and apoptotic factors have serious implications in busulfan-induced chemo-brain and testicular damages.
E. Tesi +9 more
semanticscholar +1 more source
Annals of Internal Medicine, 1990
Excerpt To the Editor:Two recent letters (1, 2) described the use of anticonvulsants to prevent seizures secondary to high-dose busulfan therapy as a preparative regimen for bone marrow transplanta...
W E, Fitzsimmons, R, Ghalie, H, Kaizer
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Excerpt To the Editor:Two recent letters (1, 2) described the use of anticonvulsants to prevent seizures secondary to high-dose busulfan therapy as a preparative regimen for bone marrow transplanta...
W E, Fitzsimmons, R, Ghalie, H, Kaizer
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Toxicology, 2022
Busulfan, a chemotherapeutic agent for cancer, has detrimental effects on germ cells and fertility, yet the specific mechanisms remain largely uncertain. The blood-testis barrier (BTB) maintains a suitable microenvironment for germ cells self-renewal and
Jianan Zhao +8 more
semanticscholar +1 more source
Busulfan, a chemotherapeutic agent for cancer, has detrimental effects on germ cells and fertility, yet the specific mechanisms remain largely uncertain. The blood-testis barrier (BTB) maintains a suitable microenvironment for germ cells self-renewal and
Jianan Zhao +8 more
semanticscholar +1 more source
Clinical Pharmacology and Therapeutics, 1983
Busulfan kinetics were studied in patients with chronic myelocytic leukemia after oral doses of 2, 4, and 6 mg. The plasma concentration-time data could be fitted to a zero-order absorption one-compartment open model. The elimination rate constant averaged 0.27 +/- 0.05 hr-1 (SD). The plasma AUC was linearly related to the dose.
H, Ehrsson +3 more
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Busulfan kinetics were studied in patients with chronic myelocytic leukemia after oral doses of 2, 4, and 6 mg. The plasma concentration-time data could be fitted to a zero-order absorption one-compartment open model. The elimination rate constant averaged 0.27 +/- 0.05 hr-1 (SD). The plasma AUC was linearly related to the dose.
H, Ehrsson +3 more
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Theriogenology, 2022
Busulfan (Bus), is an alkylating agent widely used in chemotherapy which has been proven to possess toxic side effects on testicles. This study was carried out to compare the probable treatment effects of resveratrol (Res) or/and l-carnitine (Lca), as ...
H. Hafezi +3 more
semanticscholar +1 more source
Busulfan (Bus), is an alkylating agent widely used in chemotherapy which has been proven to possess toxic side effects on testicles. This study was carried out to compare the probable treatment effects of resveratrol (Res) or/and l-carnitine (Lca), as ...
H. Hafezi +3 more
semanticscholar +1 more source
Mechanisms underlying impaired spermatogenic function in orchitis induced by busulfan.
Reproductive Toxicology, 2022Busulfan is an alkylating agent commonly used in cancer chemotherapy. It is also an ideal agent for preparing transplant recipients of spermatogonial stem cells because of its high efficiency in destroying endogenous germ cells in the testis.
L. Zhao +4 more
semanticscholar +1 more source
The Lancet Haematology, 2020
BACKGROUND Further improvement of preparative regimens before allogeneic haemopoietic stem cell transplantation (HSCT) is an unmet medical need for the growing number of older or comorbid patients with acute myeloid leukaemia or myelodysplastic syndrome.
D. Beelen +58 more
semanticscholar +1 more source
BACKGROUND Further improvement of preparative regimens before allogeneic haemopoietic stem cell transplantation (HSCT) is an unmet medical need for the growing number of older or comorbid patients with acute myeloid leukaemia or myelodysplastic syndrome.
D. Beelen +58 more
semanticscholar +1 more source
Systems Biology in Reproductive Medicine, 2021
There are few treatment options, including the use of natural phenolics-based combination therapy for mitigating male infertility conditions associated with chemotherapy. Busulfan is an anti-cancer drug that leads to testicular problems in humans.
S. Abarikwu +5 more
semanticscholar +1 more source
There are few treatment options, including the use of natural phenolics-based combination therapy for mitigating male infertility conditions associated with chemotherapy. Busulfan is an anti-cancer drug that leads to testicular problems in humans.
S. Abarikwu +5 more
semanticscholar +1 more source
JAMA, 1962
THE TREATMENT of chronic granulocytic leukemia with busulfan (Myleran) (1,4-dimethanesulfonoxybutane ) in pregnancy is, apparently, uncommon. In reviewing the literature, only 2 reported cases were found in which busulfan alone had been used during pregnancy.
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THE TREATMENT of chronic granulocytic leukemia with busulfan (Myleran) (1,4-dimethanesulfonoxybutane ) in pregnancy is, apparently, uncommon. In reviewing the literature, only 2 reported cases were found in which busulfan alone had been used during pregnancy.
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