Results 91 to 100 of about 104,308 (265)

Effects of Trimethoprim on Three Previously Proposed Putative Biomarkers for OCT2/MATE‐Mediated Renal Drug‐Drug Interactions in Healthy Volunteers

Clinical Pharmacology &Therapeutics, EarlyView.
Regulatory agencies request the assessment of the potential of new drugs to cause transporter‐mediated drug‐drug interactions (DDI). This assessment can be improved by integrating endogenous biomarkers during drug development. Regarding the renal excretion of drugs such as metformin, the organic cation transporter (OCT) 2 and multidrug and toxin ...
Jana Picurová, Fabian Müller, Daniel Auge, Jörg König, Martin F. Fromm, Arne Gessner   +5 more
wiley   +1 more source

Postbiotic Sodium Butyrate Mitigates Hypertension and Kidney Dysfunction in Juvenile Rats Exposed to Microplastics

Antioxidants
Background: Plastic production has led to widespread microplastic (MP) pollution, with children more vulnerable to MPs than adults. However, the mechanisms linking MP exposure to hypertension and kidney disease in children remain unclear.
You-Lin Tain, Ying-Jui Lin, Chih-Yao Hou, Guo-Ping Chang-Chien, Shu-Fen Lin, Chien-Ning Hsu   +5 more
doaj   +1 more source

Fecal Microbiota Transplantation and Microbiota‐Based Therapeutics in Allogeneic Hematopoietic Stem Cell Transplantation: Current Evidence and Future Directions

Clinical Pharmacology &Therapeutics, EarlyView.
The intestinal microbiome is a key regulator of immune homeostasis, metabolism, and epithelial barrier integrity. In patients with malignant hematological diseases, particularly those undergoing hematopoietic stem cell transplantation, microbiome perturbations by reduced diversity, pathobiont expansion, and loss of beneficial metabolites are common as ...
Bálint Gergely Szabó, Dorina Korózs, Michal Bator, Krisztina Jeszenszky, Viktor Lakatos, László Gopcsa, Péter Reményi, János Sinkó   +7 more
wiley   +1 more source

Associations Between Microbial Depletion and Autonomic Dysregulation in Binge‐Eating Disorder

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective The interplay between the gut microbiome and autonomic nervous system remains unexplored in binge‐eating disorder (BED). We aimed to explore specific microbial alterations in BED and examine their potential association with cardiac vagal tone as a distinct bio‐behavioral phenotype.
Shuang Liang, Esben Strodl, Leanne Barron, Matthew Bambling, Luis Vitetta   +4 more
wiley   +1 more source

Anaerostipes hadrus, a butyrate-producing bacterium capable of metabolizing 5-fluorouracil

mSphere
Anaerostipes hadrus (A. hadrus) is a dominant species in the human gut microbiota and considered a beneficial bacterium for producing probiotic butyrate. However, recent studies have suggested that A.
Danping Liu, Li-Sheng Xie, Shitao Lian, Kexin Li, Yun Yang, Wen-Zhao Wang, Songnian Hu, Shuang-Jiang Liu, Chang Liu, Zilong He   +9 more
doaj   +1 more source

Buried Interface Engineering via a Bifunctional Guanidino‐Carboxyl Molecular Bridge for Enhanced Performance and Stability in Perovskite Solar Cells

EcoEnergy, EarlyView.
A bifunctional molecular bridge using 4‐guanidinobutanoic acid (GCC) is constructed to comprehensively tailor the buried interface of PSCs. By passivating oxygen vacancies, optimizing energy‐level matching, and regulating perovskite crystallization, this strategy simultaneously boosts the power conversion efficiency to 25.37% (20.01% for 13.4 cm2) and ...
Ying Liang, Wenjing Zhou, Yongxuan Zhou, Jiahao Cheng, Wenjian Shen, Guijie Liang, Bin Li, Yong Peng, Zaifang Li, Liu Liu, Jun Yao, Yi‐Bing Cheng, Wangnan Li   +12 more
wiley   +1 more source

Carbon Anodes for Low‐Temperature Nonaqueous Alkali Metal‐Ion Batteries

EcoEnergy, EarlyView.
This review summarizes recent progress in carbon anodes for low‐temperature nonaqueous alkali‐metal ion batteries. Fundamental thermodynamic and kinetic limitations are examined, alongside a systematic discussion of graphite, hard carbon, and emerging carbon architectures.
Zhichun Miao, Dandan Yu, Guojie Liu, Yuyang Qin, Jingyun Mou, Wenlong Song, Lu Shi, Zengqin Xiao, Xin Yuan, Huayu Chen, Laishun Qin, Da Chen   +11 more
wiley   +1 more source

Charting Water‐in‐Natural‐Salt (WiNS) Electrolytes. Part I: Effect of Anion's Alkyl Tail Length

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
At 20 m, potassium carboxylates from formate to butyrate reveal anion tail‐controlled nanostructure. SAXS shows a pre‐peak shifting to lower q with chain length. Molecular dynamics reproduces S(q) and attributes it to concentration fluctuations forming bicontinuous segregation.
Alessandra Del Giudice, Laura Hildebrandt, Jin Han, Radhika Krishna Hema, Luciano Galantini, Stefano Passerini, Alberto Varzi, Alessandro Mariani   +7 more
wiley   +1 more source

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

Hyperoxia as a driver of gut dysbiosis

Frontiers in Microbiology
The mammalian colon lumen exists in a highly anaerobic environment (oxygen partial pressure (PO2) < 1 mmHg), which promotes the growth of beneficial obligate anaerobes (OA) while limiting the expansion of pathogenic facultative anaerobes (FA).
Hang Wu, Wenxia Zeng, Ninan Dai, Juan Gu, Ying He, Han Qin, Long Lin, Xiaoyun Fu, Bao Fu, Zhouxiong Xing, Zhouxiong Xing   +10 more
doaj   +1 more source