Results 91 to 100 of about 225,175 (395)

Abnormalities in microbiota/butyrate/FFAR3 signaling in aging gut impair brain function

JCI Insight
Aging-related abnormalities in gut microbiota are associated with cognitive decline, depression, and anxiety, but underlying mechanisms remain unstudied.
S. Mishra, Shalini Jain, Bo Wang, Shaohua Wang, Brandi C Miller, Jea Y. Lee, C. Borlongan, Lin Jiang, Julie Pollak, S. Taraphder, B. Layden, S. Rane, Hariom Yadav   +12 more
semanticscholar   +1 more source

Butyrate to combat obesity and obesity‐associated metabolic disorders: Current status and future implications for therapeutic use

Obesity Reviews, 2022
Evidence is increasing that disturbances in the gut microbiome may play a significant role in the etiology of obesity and type 2 diabetes. The short chain fatty acid butyrate, a major end product of the bacterial fermentation of indigestible ...
Thirza van Deuren, E. Blaak, E. Canfora
semanticscholar   +1 more source

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

Butyrate and iso-butyrate: a new perspective on nutrition prevention of gestational diabetes mellitus

Nutrition & Diabetes
Background Dietary imbalance, such as a lower proportion of complex carbohydrates and a higher protein diet, may contribute to gestational diabetes mellitus (GDM) risks through their metabolisms.
Weiling Han, Jia Wang, Xin Yan, Cheng Liu, Junhua Huang, Lirui Zhang, Yujie Zhang, Yiqing Zhao, Yanmei Hou, Wei Zheng, Guanghui Li   +10 more
doaj   +1 more source

Evidence for proton-pump inhibitor (PPI)-associated dysbiosis in metabolically unhealthy obesity

Frontiers in Endocrinology, 2023
Obesity adversely impacts millions of American adults by predisposing them to significant health risks and further complications. Obesity is differentiated into two groups: metabolically healthy and metabolically unhealthy.
Melissa A. Burmeister, Tara E. Smith, Timothy K. Fincher, Abby J. Weldon   +3 more
doaj   +1 more source

Role of gut microbiota in the aetiology of obesity: proposed mechanisms and review of the literature [PDF]

, 2016
The aetiology of obesity has been attributed to several factors (environmental, dietary, lifestyle, host, and genetic factors); however none of these fully explain the increase in the prevalence of obesity worldwide.
Edwards, Christine Ann, Gerasimidis, Konstantinos, Khan, Muhammad Jaffar, Shaikh, M. Guftar   +3 more
core   +3 more sources

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

Time‐Dependent Changes in Effects of Butyrate on Human Gingival Fibroblasts

Clinical and Experimental Dental Research
Objectives Butyrate is one of major metabolites of periodontitis‐associated bacteria and often detected in periodontal pockets. Butyrate has been considered to affect human gingival fibroblasts (HGFs); however, there was no information on its long‐term ...
Haruki Otani, Jumpei Washio, Aoi Kunitomi, Satoko Sato, Yuki Abiko, Shiori Sasaki, Kazumasa Ohashi, Satoru Yamada, Nobuhiro Takahashi   +8 more
doaj   +1 more source

Microbial metabolite butyrate promotes induction of IL-10+IgM+ plasma cells.

PLoS ONE, 2022
The microbially-derived short-chain fatty acid butyrate is a central inhibitor of inflammatory innate and adaptive immune responses. Emerging evidence suggests that butyrate induces differentiation of IL-10-producing (IL-10+) regulatory B cells. However,
Bandik Föh, Jana Sophia Buhre, Hanna B Lunding, Maria E Moreno-Fernandez, Peter König, Christian Sina, Senad Divanovic, Marc Ehlers   +7 more
doaj   +1 more source

Butyrate, a postbiotic of intestinal bacteria, affects pancreatic cancer and gemcitabine response in in vitro and in vivo models.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer. The characteristic excessive stromatogenesis accompanying the growth of this tumor is believed to contribute to chemoresistance which, together with drug toxicity, results in poor clinical ...
C. Panebianco, A. Villani, F. Pisati, F. Orsenigo, M. Ulaszewska, T. Latiano, Adele Potenza, A. Andolfo, F. Terracciano, C. Tripodo, F. Perri, V. Pazienza   +11 more
semanticscholar   +1 more source