Results 71 to 80 of about 225,175 (395)

Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion

Nature Communications, 2021
Emerging evidence is revealing that alterations in gut microbiota are associated with colorectal cancer (CRC). However, very little is currently known about whether and how gut microbiota alterations are causally associated with CRC development.
S. Okumura, Y. Konishi, Megumi Narukawa, Y. Sugiura, S. Yoshimoto, Yuriko Arai, Shintaro Sato, Y. Yoshida, Shunya Tsuji, Ken Uemura, Masahiro Wakita, T. Matsudaira, Tomonori Matsumoto, Shimpei Kawamoto, Akiko Takahashi, Yoshiro Itatani, H. Miki, M. Takamatsu, K. Obama, K. Takeuchi, M. Suematsu, Naoko Ohtani, Y. Fukunaga, M. Ueno, Y. Sakai, S. Nagayama, E. Hara   +26 more
semanticscholar   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Sodium Butyrate Ameliorates Oxidative Stress-Induced Intestinal Epithelium Barrier Injury and Mitochondrial Damage through AMPK-Mitophagy Pathway

Oxidative Medicine and Cellular Longevity, 2022
Sodium butyrate has gained increasing attention for its vast beneficial effects. However, whether sodium butyrate could alleviate oxidative stress‐induced intestinal dysfunction and mitochondrial damage of piglets and its underlying mechanism remains ...
Xin Li, Chunchun Wang, Jiang Zhu, Qian Lin, Minjie Yu, J.S. Wen, Jie Feng, Caihong Hu   +7 more
semanticscholar   +1 more source

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

Sodium Butyrate Ameliorates Gut Microbiota Dysbiosis in Lupus-Like Mice

Frontiers in Nutrition, 2020
Gut microbiota has a strong influence on the onset and development of systemic lupus erythematosus (SLE), and several studies have demonstrated the effectiveness of microbiota-derived butyrate to ameliorate SLE.
Hanchang He, Hanchang He, Haoming Xu, Jing Xu, Hailan Zhao, Qianyun Lin, Youlian Zhou, Yuqiang Nie   +7 more
doaj   +1 more source

Role of Butyrate, a Gut Microbiota Derived Metabolite, in Cardiovascular Diseases: A comprehensive narrative review

Frontiers in Pharmacology, 2022
Cardiovascular diseases (CVD) are major causes of death worldwide. Recently, new roles for intestinal microbiota in pathology and treatment of CVD have been proposed.
Parichehr Amiri, S. Hosseini, Samad Ghaffari, Helda Tutunchi, S. Ghaffari, Erfan Mosharkesh, Samira Asghari, Neda Roshanravan   +7 more
semanticscholar   +1 more source

Opinion: Gavage Administration of MXene as a Route‐Specific Alternative to Intravenous Injection into the Bloodstream of Laboratory Animals for Reducing Systemic Nanotoxicity Risks in Immunosuppression and Post‐Transplantation Models with Bile Acid Modification

Advanced Healthcare Materials, EarlyView.
Recent studies reported immunosuppressive properties of specific MXene nanomaterials. Their intravenous injection into the bloodstream of laboratory animals has been a common delivery method to suppress systemic inflammation and prevent transplant rejection.
Alireza Rafieerad, M. Akif Rahman, Ahmad Amiri   +2 more
wiley   +1 more source

Sodium oligomannate modulates the gut-brain axis to alleviate post-stroke cognitive impairment by restoring butyrate metabolism

Microbiome
Background Post-stroke cognitive impairment (PSCI) affects up to half of stroke survivors, severely impacting their quality of life. Despite its prevalence, the pathogenesis of PSCI remains poorly understood, and no specific pharmacological treatments ...
Yueran Ren, Jingru Liang, Jiahui Xie, Weike Hu, Minlin Lai, Xiao Li, Jiafeng Zhang, Yifeng Zheng, Qiheng Wu, Hongwei Zhou, Jia Yin   +10 more
doaj   +1 more source

Suppression of fibrosis in human pterygium fibroblasts by butyrate and phenylbutyrate [PDF]

International Journal of Ophthalmology, 2017
AIM: To evaluate the antifibrogenic effects of butyrate or phenylbutyrate, a chemical derivative of butyrate, in human pterygium fibroblasts. METHODS: Human pterygium fibroblasts obtained from patient pterygium tissue were treated with butyrate or ...
Yuka Koga, Noriaki Maeshige, Hiroto Tabuchi, Mikiko Uemura, Michiko Aoyama-Ishikawa, Makoto Miyoshi, Chikako Katakami, Makoto Usami   +7 more
doaj   +1 more source

Effects of different levels of dietary butyric acid on some growth performance, immunity and digestive enzymes activity of yellowfin seabream (Acanthopagrus latus Houttuyn, 1782) [PDF]

تغذیه آبزیان, 2020
This study was conducted to evaluate the effects of different dietary levels of butyric acid on growth performance, immunity and digestive enzyme activities in yellowfin seabream (Acanthopagrus latus) (8.59 ± 0.33 g) at the period of 60 days.
Gholamreza Badzohreh, Shirin Zarei, Reza Davoodi, Mahmoud Nafisi Bahabadi, Farzad Salehi, Vahid Morshedi, Ebrahim Sotoudeh   +6 more
doaj   +1 more source