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Butyrophenone und strukturanaloge Verbindungen
1998Trotz einer ahnlichen chemischen Grundstruktur und eines demzufolge ahnlichen Metabolismus verhalten sich die einzelnen Butyrophenone und Diphenylbutylpiperidine bezuglich Adsorption, Verteilung und Elimination sehr unterschiedlich, weitgehend bedingt durch unterschiedlich lipophile Eigenschaften.
K. Heininger +6 more
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Neuroleptika (Phenothiazine, Butyrophenone)
1992Zu den Neuroleptika zahlen Phenothiazin- und Butyrophenon-derivate. Ubliche antiemetisch wirksame Einzeldosen von Phenothiazinen wie Chlorpromazin (25–50 mg), Prochlorperazin (5–10–25 mg), Triflupromazin (10–20 mg), Levomepromazin (10–25 mg), Perphenazin (z.B. 5 mg), Fluphenazin (z.B.
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New alkylating agents: butyrophenone derivatives.
Anticancer research, 1986The antimitotic properties associated with the bis (2-chloroethyl) amino group are well known, a number of compounds bearing this group being of therapeutic interest. The choice of a suitable supporting moiety for this group is important. Our experiments on a butyrophenone derivative, ketocaine, which possesses local anesthetic activity, showed that ...
I, Galatulas +4 more
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Anticholinesterase activity of some butyrophenones.
Archives internationales de pharmacodynamie et de therapie, 1978The anticholinesterase (antiChE) activity of haloperidol, droperidol and trifluperidol was studied by employing dog plasma as a cholinesterase source and changes in arterial blood pressure, elecited by a mixture of acetylcholine (Ach) and dog plasma with or without those drugs, as an indicator of their antiChE activity. When butyrophenones were present
Z B, Fortes, R, Scivoletto, C C, Reis
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