Results 31 to 40 of about 2,864 (204)

Enhancing the possibilities of comprehensive two-dimensional liquid chromatography through hyphenation of purely aqueous temperature-responsive and reversed-phase liquid chromatography [PDF]

, 2018
Comprehensive two-dimensional liquid chromatography (LC X LC) allows for substantial gains in theoretical peak capacity in the field of liquid chromatography.
Baert, Mathijs, de Villiers, Andre, Desmet, Gert, Du Prez, Filip, Lynen, Frederic, Martens, Steven   +5 more
core   +1 more source

The fast‐dissociating D2 antagonist antipsychotic JNJ‐37822681 is a neuronal Kv7 channel opener: Potential repurposing for epilepsy treatment

British Journal of Pharmacology, Volume 182, Issue 22, Page 5574-5595, November 2025.
Abstract Background and Purpose Pharmacological activation of neuronal M‐current mediated by Kv7 (Kv7.2–5) potassium channels is a validated mechanism for epilepsy treatment. However, since the market withdrawal of the prototype Kv7 activator retigabine, no Kv7 activator is clinically available for this condition.
Lidia Carotenuto, Oliver Keminer, Giusy Carleo, Andrea Zaliani, Antonio Leo, Rita Citraro, Giovambattista De Sarro, Nina Dirkx, Marcus Kaji, Sarah Weckhuysen, Jeanette Reinshagen, Vincenzo Barrese, Natascia Guida, Carmine Ostacolo, Francesco Miceli, Philip Gribbon, Maurizio Taglialatela   +16 more
wiley   +1 more source

Modular Synthesis of Heterobenzylic Amines via Carbonyl Azinylative Amination

Angewandte Chemie, Volume 136, Issue 42, October 14, 2024.
An indium metal‐mediated carbonyl azinylative amination (CAzA) reaction provides an operationally straightforward protocol for the multicomponent coupling carbonyls, amines and 2‐iodo azines to form α‐alkyl, α′‐2‐azinyl amines. This modular reaction displays a broad scope and only a metal reductant is needed to generate a reactive 2‐azinyl nucleophile.
Alex A. Rafaniello, Roopender Kumar, Rachel C. Phillips, Matthew J. Gaunt   +3 more
wiley   +2 more sources

The influence of microbiome‐derived amino acids metabolites in shaping the glioma immunosuppressive microenvironment

Interdisciplinary Medicine, Volume 3, Issue 3, May 2025.
Left: The disruption of the balance between carcinogenic bacteria and probiotics mediated by antibiotics, protein, and glucose intake. Middle: The gut microbiota‐derived amino acids, primarily through tryptophan, tyrosine, arginine, and branched‐chain amino acid pathways, regulate glioma development via mechanisms such as AHR activation, metabolic ...
Qianquan Ma, Zhihao Song, Chenlong Yang, Zijin Zhao, Guodong Tang, Jia You, Chong Zeng, Jun Yang, Qing Liu, Haoyu Li, Wei Huang   +10 more
wiley   +1 more source

Association of statins, gliptins, and antipsychotics with bullous pemphigoid: A case–control study in the Cretan population

The Journal of Dermatology, Volume 52, Issue 2, Page 291-298, February 2025.
Abstract Bullous pemphigoid (BP) is an autoimmune blistering disorder predominantly affecting the elderly. Recently, many studies have shed light on the effect of specific drug intake and comorbidities on the development of BP. The purpose of this study was to investigate the association of specific drug class intake and comorbidities with the ...
Eirini Kavvalou, Konstantinos Krasagakis, Gregory Chlouverakis, Paraskevi Xekouki, Vasiliki Daraki, Charikleia Kouvidou, Eleni Lagoudaki, Sabine‐Elke Krüger‐Krasagakis   +7 more
wiley   +1 more source

The use of thiafentanil oxalate and azaperone for reversible immobilisation of African buffalo (Syncerus caffer) within a nature reserve — Short communication [PDF]

, 2015
Although thiafentanil oxalate has been widely used for wildlife immobilisation on different species, no report has been published about its usefulness on African buffalo (Syncerus caffer).
Luyt, Eustatius, Raath, Cobus, Szabó, Zoltán, Venter, Diederik   +3 more
core   +1 more source

Development of the Japanese Anticholinergic Risk Scale: English translation of the Japanese article

Geriatrics &Gerontology International, Volume 25, Issue 1, Page 5-13, January 2025.
Background Anticholinergic burden, reflecting the cumulative impact of medications with anticholinergic properties, significantly predicts adverse drug reactions and geriatric syndromes in older adults. Although anticholinergic risk scales (ARS) have been developed and validated in various countries, none have been tailored specifically for Japan.
Fumihiro Mizokami, Tomohiro Mizuno, Rena Taguchi, Izumi Nasu, Sayaka Arai, Keiichiro Higashi, Ayaka Matsumoto, Miwako Kamei, Taro Kojima, Takayoshi Sakai, Yuuka Shibata, Yasushi Takeya, Masaki Mogi, Shizuo Yamada, Masahiro Akishita, Japanese Society of Geriatric Pharmacy Working Group on Japanese Anticholinergic Risk Scale   +15 more
wiley   +1 more source

Long-term treatment with haloperidol affects neuropeptide S and NPSR mRNA levels in the rat brain [PDF]

, 2015
OBJECTIVE: The brainstem-derived neuropeptide S (NPS) has a multidirectional regulatory activity, especially as a potent anxiolytic factor. Accumulating data suggests that neuroleptics affect peptidergic signalling in various brain structures.
Filipczyk, Lukasz, Golyszny, Milosz, Palasz, Artur, Rojczyk, Ewa, Wiaderkiewicz, Ryszard, Worthington, John J.   +5 more
core   +1 more source

Olanzapine for the Prevention of Chemotherapy-Induced Nausea and Vomiting [PDF]

, 2016
BACKGROUND We examined the efficacy of olanzapine for the prevention of nausea and vomiting in patients receiving highly emetogenic chemotherapy.
Bajaj, Madhuri, Biggs, David, Dietrich, Leah, Lafky, Jacqueline M., Liu, Heshan, Loprinzi, Charles L., Navari, Rudolph M., Powell, Steven F., Qin, Rui, Ruddy, Kathryn J.   +9 more
core   +1 more source

Current Status of Amine Dehydrogenases: From Active Site Architecture to Diverse Applications Across a Broad Substrate Spectrum

ChemCatChem, Volume 16, Issue 24, December 20, 2024.
Amine dehydrogenases (AmDHs) are NAD(P)H‐depended oxidoreductases that rely on NAD(P)H as cofactor to catalyze the reductive amination of carbonyl‐containing compounds in the presence of ammonia. Depending on the catalytic activities of other enzymes as reaction partners, AmDHs find applications in various synthetic pathways, as well as in kinetic ...
Vasilis Tseliou, Marcelo F. Masman, Tanja Knaus, Francesco G. Mutti   +3 more
wiley   +1 more source