Results 211 to 220 of about 18,202 (269)

Ratiometric imaging of butyrylcholinesterase activity in mice with nonalcoholic fatty liver using an AIE-based fluorescent probe.

Journal of materials chemistry. B, 2022
Butyrylcholinesterase (BChE) is an essential human biomarker which is related to liver and neurodegenerative diseases. It is of great significance to develop a fluorescent probe that can image BChE in vitro and in vivo.
Chunbai Xiang, Jingjing Xiang, Xing Yang, Chunbin Li, Lihua Zhou, Daoyong Jiang, Yonglin Peng, Zhen-Yi Xu, Guanjun Deng, Baode Zhu, Pengfei Zhang, Lintao Cai, P. Gong   +12 more
semanticscholar   +1 more source

Fluorescent Determination of Butyrylcholinesterase Activity and Its Application in Biological Imaging and Pesticide Residue Detection.

ACS Sensors, 2021
Butyrylcholinesterase (BChE) is an essential human cholinesterase relevant to liver conditions and neurodegenerative diseases, which makes it a pivotal biomarker of health.
Qian Zhang, Caixia Fu, Xinjie Guo, Jian Gao, P. Zhang, Caifeng Ding   +5 more
semanticscholar   +1 more source

Highly Potent and Selective Butyrylcholinesterase Inhibitors for Cognitive Improvement and Neuroprotection.

Journal of Medicinal Chemistry, 2021
Butyrylcholinesterase (BChE) has been considered as a potential therapeutic target for Alzheimer's disease (AD) because of its compensation capacity to hydrolyze acetylcholine (ACh) and its close association with Aβ deposit. Here, we identified S06-1011 (
Qi Li, Ying Chen, Shuaishuai Xing, Qinghong Liao, Baichen Xiong, Yuanyuan Wang, Weixuan Lu, Siyu He, F. Feng, Wenyuan Liu, Yao Chen, Haopeng Sun   +11 more
semanticscholar   +1 more source

The impact of some natural phenolic compounds on carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and α‐glycosidase enzymes: An antidiabetic, anticholinergic, and antiepileptic study

Journal of Biochemical and Molecular Toxicology, 2017
Lhami Gülçin, Parham Taslimi, Cuneyt Caglayan   +2 more
exaly   +2 more sources

The Butyrylcholinesterase Knockout Mouse as a Model for Human Butyrylcholinesterase Deficiency [PDF]

The Journal of Pharmacology and Experimental Therapeutics, 2008
Butyrylcholinesterase (BChE) is an important enzyme for metabolism of ester drugs. Many humans have partial or complete BChE deficiency due to genetic variation. Our goal was to create a mouse model of BChE deficiency to allow testing of drug toxicity.
Michaela Carlson, Oksana Lockridge, Ellen G. Duysen, Bin Li   +3 more
openaire   +2 more sources

Neurobiology of butyrylcholinesterase

Nature Reviews Neuroscience, 2003
Butyrylcholinesterase is a serine hydrolase related to acetylcholinesterase that catalyses the hydrolysis of esters of choline, including acetylcholine. Butyrylcholinesterase has unique enzymatic properties and is widely distributed in the nervous system, pointing to its possible involvement in neural function.
Sultan Darvesh, David A. Hopkins, Changiz Geula   +2 more
openaire   +3 more sources

Nitrogen‐containing flavonoid and their analogs with diverse B‐ring in acetylcholinesterase and butyrylcholinesterase inhibition

Drug development research (Print), 2020
In this study, a series of new flavones (2‐phenyl‐chromone), 2‐naphthyl chromone, 2‐anthryl‐chromone, or 2‐biphenyl‐chromone derivatives containing 6 or 7‐substituted tertiary amine side chain were designed, synthesized, and evaluated in ...
Qiaojun Lu, Ya-Ming Chen, Hao-Ran Liu, Jian-Ye Yan, Pei-Wu Cui, Qian-Fan Zhang, Xiao-hui Gao, Xing Feng, Yingzi Liu   +8 more
semanticscholar   +1 more source

Butyrylcholinesterase deficiency

Annales de biologie clinique, 2016
Butyrylcholinesterase (EC 3.1.1.8; BChE) is a sister enzyme of acetylcholinesterase. Though BChE lacks obvious physiological functions, it is of toxicological and pharmacological importance in detoxifying or catabolising ester-containing drugs. Furthermore, individuals deficient in BChE appear asymptomatic, apart from a heightened sensitivity to the ...
Sébastien Courcelle, Hervé Delacour, Emmanuel Dedome, Franck Ceppa, Blandine Hary   +4 more
openaire   +3 more sources

A mechanistic model for butyrylcholinesterase

Biochimica et Biophysica Acta (BBA) - Enzymology, 1979
A plausible mechanism of action of horse serum butyrylcholinesterase is proposed. It includes substrate activation at the level of deacylation. The rate constant for the acylation of the enzyme appears to be much greater than the rate constant for the deacylation, at low substate concentrations.
Håkan Eriksson, Klas-Bertil Augustinsson   +1 more
openaire   +3 more sources

Structure and therapeutic uses of butyrylcholinesterase: Application in detoxification, Alzheimer's disease, and fat metabolism

Medicinal research reviews (Print), 2020
Structural information of butyrylcholinesterase (BChE) and its variants associated with several diseases are discussed here. Pure human BChE has been proved safe and effective in treating organophosphorus (OPs) poisoning and has completed Phase 1 and 2 ...
Shuaishuai Xing, Qi Li, Baichen Xiong, Yao Chen, F. Feng, Wenyuan Liu, Haopeng Sun   +6 more
semanticscholar   +1 more source